Details for: Capn1

Gene ID: 29153

Symbol: Capn1

Ensembl ID: ENSRNOG00000020935

Description: calpain 1

Associated with

Other Information

Genular Protein ID: 1490713460

Symbol: CAN1_RAT

Name: Calcium-activated neutral proteinase 1

UniProtKB Accession Codes:

P97571

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 CDD 3 CTD 1 ChEBI 11 ChEMBL 1 EC 1 EMBL 2 Ensembl 3 EvolutionaryTrace 1 GO 27 Gene3D 3 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 10 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8950173

Title: Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human.

PubMed ID: 8950173

DOI: 10.1016/s0167-4781(96)00135-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11893336

Title: A Ca(2+) switch aligns the active site of calpain.

PubMed ID: 11893336

DOI: 10.1016/s0092-8674(02)00659-1

PubMed ID: 14656436

Title: Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement.

PubMed ID: 14656436

DOI: 10.1016/j.str.2003.11.007

PubMed ID: 15491615

Title: Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.

PubMed ID: 15491615

DOI: 10.1016/j.jmb.2004.09.016

Sequence Information:

  • Length: 713
  • Mass: 82119
  • Checksum: 6E664600B0EFAEBB
  • Sequence:
    • MAEELITPVY CTGVSAQVQK QRDKELGLGR HENAIKYLGQ DYENLRARCL QNGVLFQDDA 
FPPVSHSLGF KELGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA 
IASLTLNETI LHRVVPYGQS FQEGYAGIFH FQLWQFGEWV DVVVDDLLPT KDGKLVFVHS 
AQGNEFWSAL LEKAYAKVNG SYEALSGGCT SEAFEDFTGG VTEWYDLQKA PSDLYQIILK 
ALERGSLLGC SINISDIRDL EAITFKNLVR GHAYSVTDAK QVTYQGQRVN LIRMRNPWGE 
VEWKGPWSDN SYEWNKVDPY EREQLRVKME DGEFWMSFRD FIREFTKLEI CNLTPDALKS 
RTLRNWNTTF YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LEEVDDADDY DSRESGCSFL 
LALMQKHRRR ERRFGRDMET IGFAVYQVPR ELAGQPVHLK RDFFLANASR AQSEHFINLR 
EVSNRIRLPP GEYIVVPSTF EPNKEGDFLL RFFSEKKAGT QELDDQIQAN LPDEKVLSEE 
EIDDNFKTLF SKLAGDDMEI SVKELQTILN RIISKHKDLR TNGFSLESCR SMVNLMDRDG 
NGKLGLVEFN ILWNRIRNYL TIFRKFDLDK SGSMSAYEMR MAIEAAGFKL NKKLHELIIT 
RYSEPDLAVD FDNFVCCLVR LETMFRFFKI LDTDLDGVVT FDLFKWLQLT MFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.