Capn2 | ENSRNOG00000034015 | NCBI 29154

Details for: Capn2

Gene ID: 29154

Symbol: Capn2

Ensembl ID: ENSRNOG00000034015

Description: calpain 2

Associated with

Degradation of the extracellular matrix
(R-RNO-1474228)
Extracellular matrix organization
(R-RNO-1474244)
Behavioral response to pain
(GO:0048266)
Blastocyst development
(GO:0001824)
Calcium-dependent cysteine-type endopeptidase activity
(GO:0004198)
Calcium ion binding
(GO:0005509)
Calpain complex
(GO:0110158)
Cell projection
(GO:0042995)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to lipopolysaccharide
(GO:0071222)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Female pregnancy
(GO:0007565)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Lysosome
(GO:0005764)
Membrane raft
(GO:0045121)
Myoblast fusion
(GO:0007520)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Perinuclear endoplasmic reticulum
(GO:0097038)
Plasma membrane
(GO:0005886)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of phosphatidylcholine biosynthetic process
(GO:2001247)
Protein-containing complex binding
(GO:0044877)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Pseudopodium
(GO:0031143)
Regulation of interleukin-6 production
(GO:0032675)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to mechanical stimulus
(GO:0009612)

Other Information

Proteins

Calpain-2 catalytic subunit

Genular Protein ID: 1957066514

Symbol: CAN2_RAT

Name: Calpain-2 catalytic subunit

UniProtKB Accession Codes:

Q07009

Database IDs:

Citations:

PubMed ID: 8218419

Title: Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit.

PubMed ID: 8218419

DOI: 10.1016/0167-4781(93)90040-k

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11342050

Title: Ca(2+)-induced structural changes in rat m-calpain revealed by partial proteolysis.

PubMed ID: 11342050

DOI: 10.1016/s0167-4838(00)00286-7

PubMed ID: 11102442

Title: Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain.

PubMed ID: 11102442

DOI: 10.1074/jbc.m007352200

PubMed ID: 7635186

Title: Active site residues in m-calpain: identification by site-directed mutagenesis.

PubMed ID: 7635186

DOI: 10.1016/0014-5793(95)00691-2

PubMed ID: 10601010

Title: Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.

PubMed ID: 10601010

DOI: 10.1093/emboj/18.24.6880

PubMed ID: 19020622

Title: Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.

PubMed ID: 19020622

DOI: 10.1038/nature07353

PubMed ID: 19020623

Title: Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.

PubMed ID: 19020623

DOI: 10.1038/nature07451

Sequence Information:

Length: 700
Mass: 79919
Checksum: 296B0DC3BEEF5B90
Sequence:

MAGIAMKLAK DREAAEGLGS HERAIKYLNQ DYETLRNECL EAGALFQDPS FPALPSSLGF 
KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI 
LARVVPLDQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL 
LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELRKP PPNLFKIIQK ALEKGSLLGC 
SIDITSAADS EAVTYQKLVK GHAYSVTGAE EVESSGSLQK LIRIRNPWGQ VEWTGKWNDN 
CPSWNTVDPE VRANLTERQE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTC DSYKKWKLTK 
MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDDED GERGCTFLVG LIQKHRRRQR 
KMGEDMHTIG FGIYEVPEEL TGQTNIHLSK NFFLTTRARE RSDTFINLRE VLNRFKLPPG 
EYVLVPSTFE PHKNGDFCIR VFSEKKADYQ TVDDEIEANI EEIEANEEDI GDGFRRLFAQ 
LAGEDAEISA FELQTILRRV LAKREDIKSD GFSIETCKIM VDMLDEDGSG KLGLKEFYIL 
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKLPC QLHQVIVARF ADDELIIDFD 
NFVRCLVRLE ILFKIFKQLD PENTGTIQLD LISWLSFSVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Capn2

Associated with

Other Information

Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit. PubMed ID: 8218419

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ca(2+)-induced structural changes in rat m-calpain revealed by partial proteolysis. PubMed ID: 11342050

Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain. PubMed ID: 11102442

Active site residues in m-calpain: identification by site-directed mutagenesis. PubMed ID: 7635186

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation. PubMed ID: 10601010

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. PubMed ID: 19020622

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. PubMed ID: 19020623