Psen1 | ENSRNOG00000009110 | NCBI 29192

Details for: Psen1

Gene ID: 29192

Symbol: Psen1

Ensembl ID: ENSRNOG00000009110

Description: presenilin 1

Associated with

Axon guidance
(R-RNO-422475)
Cell death signalling via nrage, nrif and nade
(R-RNO-204998)
Death receptor signaling
(R-RNO-73887)
Developmental biology
(R-RNO-1266738)
Eph-ephrin mediated repulsion of cells
(R-RNO-3928665)
Eph-ephrin signaling
(R-RNO-2682334)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Nervous system development
(R-RNO-9675108)
Neutrophil degranulation
(R-RNO-6798695)
Noncanonical activation of notch3
(R-RNO-9017802)
Notch3 activation and transmission of signal to the nucleus
(R-RNO-9013507)
Nrif signals cell death from the nucleus
(R-RNO-205043)
Nuclear signaling by erbb4
(R-RNO-1251985)
P75 ntr receptor-mediated signalling
(R-RNO-193704)
Regulated proteolysis of p75ntr
(R-RNO-193692)
Signaling by erbb4
(R-RNO-1236394)
Signaling by notch
(R-RNO-157118)
Signaling by notch3
(R-RNO-9012852)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Amyloid-beta formation
(GO:0034205)
Amyloid precursor protein catabolic process
(GO:0042987)
Amyloid precursor protein metabolic process
(GO:0042982)
Aspartic-type endopeptidase activity
(GO:0004190)
Aspartic endopeptidase activity, intramembrane cleaving
(GO:0042500)
Astrocyte activation involved in immune response
(GO:0002265)
Atpase binding
(GO:0051117)
Autophagosome assembly
(GO:0000045)
Autophagy
(GO:0006914)
Beta-catenin binding
(GO:0008013)
Blood vessel development
(GO:0001568)
Brain development
(GO:0007420)
Cadherin binding
(GO:0045296)
Cajal-retzius cell differentiation
(GO:0021870)
Calcium channel activity
(GO:0005262)
Cell fate specification
(GO:0001708)
Cerebellum development
(GO:0021549)
Cerebral cortex cell migration
(GO:0021795)
Cerebral cortex development
(GO:0021987)
Choline transport
(GO:0015871)
Dna damage response
(GO:0006974)
Dorsal/ventral neural tube patterning
(GO:0021904)
Embryonic limb morphogenesis
(GO:0030326)
Endopeptidase activity
(GO:0004175)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
Eye photoreceptor cell development
(GO:0042462)
Forebrain development
(GO:0030900)
Gene expression
(GO:0010467)
Growth factor receptor binding
(GO:0070851)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular signal transduction
(GO:0035556)
Learning or memory
(GO:0007611)
Locomotion
(GO:0040011)
Membrane protein ectodomain proteolysis
(GO:0006509)
Memory
(GO:0007613)
Mitochondrial transport
(GO:0006839)
Myeloid dendritic cell differentiation
(GO:0043011)
Myeloid leukocyte differentiation
(GO:0002573)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural retina development
(GO:0003407)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Pdz domain binding
(GO:0030165)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of l-glutamate import across plasma membrane
(GO:0002038)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein glycosylation
(GO:0006486)
Protein metabolic process
(GO:0019538)
Protein processing
(GO:0016485)
Protein transport
(GO:0015031)
Regulation of gene expression
(GO:0010468)
Regulation of neuron projection development
(GO:0010975)
Regulation of phosphorylation
(GO:0042325)
Response to oxidative stress
(GO:0006979)
Segmentation
(GO:0035282)
Somitogenesis
(GO:0001756)
Synaptic vesicle targeting
(GO:0016080)
T cell activation involved in immune response
(GO:0002286)

Other Information

Proteins

Presenilin-1

Genular Protein ID: 1921625848

Symbol: PSN1_RAT

Name: Presenilin-1

UniProtKB Accession Codes:

P97887 P97529

Database IDs:

Citations:

PubMed ID: 8710164

Title: Molecular cloning and expression of the rat homologue of presenilin-1.

PubMed ID: 8710164

DOI: 10.1016/s0304-3940(96)12449-6

PubMed ID: 9047347

Title: Cloning of the cDNA encoding rat presenilin-1.

PubMed ID: 9047347

DOI: 10.1016/s0378-1119(96)00683-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 30429473

Title: Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.

PubMed ID: 30429473

DOI: 10.1038/s41467-018-06813-x

Sequence Information:

Length: 468
Mass: 52790
Checksum: 17CB791E88A16FC0
Sequence:

MTEIPAPLSY FQNAQMSEDS HSSSVRSQND NQERQQHHDR QRLDNPESIS NGRPQSNFTR 
QVIEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIVSS LLLLFFFSFI 
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY 
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 
GDPEAQRRVP KNPKYSTQGT EREETQDTGT GSDDGGFSEE WEAQRDSHLG PHRSTPESRA 
AVQELSGSIL TSEDPEERGV KLGLGDFIFY SVLVGKASAT ASGDWNTTIA CFVAILIGLC 
LTLLLLAIFK KALPALPISI TFGLIFYFAT DYLVQPFMDQ LAFHQFYI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psen1

Associated with

Other Information

Molecular cloning and expression of the rat homologue of presenilin-1. PubMed ID: 8710164

Cloning of the cDNA encoding rat presenilin-1. PubMed ID: 9047347

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334