Details for: Il18

Gene ID: 29197

Symbol: Il18

Description: interleukin 18

Associated with

  • Angiogenesis
    (GO:0001525)
  • Apical plasma membrane
    (GO:0016324)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to parathyroid hormone stimulus
    (GO:0071374)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cholesterol homeostasis
    (GO:0042632)
  • Cytokine activity
    (GO:0005125)
  • Cytoplasm
    (GO:0005737)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of mechanical stimulus involved in sensory perception of pain
    (GO:0050966)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Establishment of skin barrier
    (GO:0061436)
  • Extracellular space
    (GO:0005615)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-18 receptor binding
    (GO:0045515)
  • Interleukin-18-mediated signaling pathway
    (GO:0035655)
  • Learning or memory
    (GO:0007611)
  • Liver regeneration
    (GO:0097421)
  • Lung development
    (GO:0030324)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell mediated cytotoxicity
    (GO:0042267)
  • Negative regulation of myoblast differentiation
    (GO:0045662)
  • Negative regulation of neutrophil apoptotic process
    (GO:0033030)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Neutrophil activation
    (GO:0042119)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of blood vessel remodeling
    (GO:2000504)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of hepatocyte proliferation
    (GO:2000347)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of macromolecule biosynthetic process
    (GO:0010557)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of male germ cell proliferation
    (GO:2000256)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of t-helper 1 cell cytokine production
    (GO:2000556)
  • Positive regulation of t-helper 2 cell differentiation
    (GO:0045630)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular permeability
    (GO:0043117)
  • Protein binding
    (GO:0005515)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cell adhesion
    (GO:0030155)
  • Regulation of circadian sleep/wake cycle, non-rem sleep
    (GO:0045188)
  • Regulation of gene expression
    (GO:0010468)
  • Response to hyperoxia
    (GO:0055093)
  • Response to hypoxia
    (GO:0001666)
  • Response to peptide hormone
    (GO:0043434)
  • Signal transduction
    (GO:0007165)
  • Sleep
    (GO:0030431)
  • T-helper 1 type immune response
    (GO:0042088)
  • Triglyceride homeostasis
    (GO:0070328)

Other Information

Genular Protein ID: 2279905228

Symbol: IL18_RAT

Name: Interleukin-18

UniProtKB Accession Codes:

P97636 O88749 P97637 Q541E6

Database IDs:

AGR 1 AlphaFoldDB 1 BindingDB 1 CTD 1 EMBL 5 GO 73 Gene3D 1 InParanoid 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 PIRSF 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 8999896

Title: Induction of interferon-gamma inducing factor in the adrenal cortex.

PubMed ID: 8999896

DOI: 10.1074/jbc.272.4.2035

PubMed ID: 9702748

Title: Cloning of rat brain interleukin-18 cDNA.

PubMed ID: 9702748

DOI: 10.1038/sj.mp.4000389

PubMed ID: 12787406

Title: IL-18 translational inhibition restricts IFN-gamma expression in crescentic glomerulonephritis.

PubMed ID: 12787406

DOI: 10.1046/j.1523-1755.2003.00077.x

Sequence Information:

  • Length: 194
  • Mass: 22303
  • Checksum: E2089AD6F1798450
  • Sequence:
    • MAAMSEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVIRS INDQVLFVDK 
RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL SVKDGRMSTL SCKNKIISFE 
EMNPPENIDD IKSDLIFFQK RVPGHNKMEF ESSLYEGHFL ACQKEDDAFK LVLKRKDENG 
DKSVMFTLTN LHQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.