Arg1 | ENSRNOG00000013304 | NCBI 29221

Details for: Arg1

Gene ID: 29221

Symbol: Arg1

Ensembl ID: ENSRNOG00000013304

Description: arginase 1

Associated with

Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Neutrophil degranulation
(R-RNO-6798695)
Adaptive immune response
(GO:0002250)
Arginase activity
(GO:0004053)
Arginine catabolic process to ornithine
(GO:0019547)
Arginine metabolic process
(GO:0006525)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to glucagon stimulus
(GO:0071377)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to interleukin-4
(GO:0071353)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Collagen biosynthetic process
(GO:0032964)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to protozoan
(GO:0042832)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Mammary gland involution
(GO:0060056)
Manganese ion binding
(GO:0030145)
Maternal process involved in female pregnancy
(GO:0060135)
Metal ion binding
(GO:0046872)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of t-helper 2 cell cytokine production
(GO:2000552)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of type ii interferon-mediated signaling pathway
(GO:0060336)
Neuronal cell body
(GO:0043025)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of neutrophil mediated killing of fungus
(GO:0070965)
Regulation of l-arginine import across plasma membrane
(GO:1905541)
Response to amine
(GO:0014075)
Response to amino acid
(GO:0043200)
Response to axon injury
(GO:0048678)
Response to cadmium ion
(GO:0046686)
Response to herbicide
(GO:0009635)
Response to lipopolysaccharide
(GO:0032496)
Response to manganese ion
(GO:0010042)
Response to methylmercury
(GO:0051597)
Response to peptide hormone
(GO:0043434)
Response to selenium ion
(GO:0010269)
Response to steroid hormone
(GO:0048545)
Response to vitamin a
(GO:0033189)
Response to vitamin e
(GO:0033197)
Response to xenobiotic stimulus
(GO:0009410)
Response to zinc ion
(GO:0010043)
Urea cycle
(GO:0000050)

Other Information

Proteins

Arginase-1

Genular Protein ID: 1182771974

Symbol: ARGI1_RAT

Name: Arginase-1

UniProtKB Accession Codes:

P07824 Q5BK93

Database IDs:

Citations:

PubMed ID: 3571256

Title: Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase.

PubMed ID: 3571256

DOI: 10.1016/s0021-9258(18)45565-2

PubMed ID: 2892837

Title: Structural organization of the gene for rat liver-type arginase.

PubMed ID: 2892837

DOI: 10.1016/s0021-9258(18)69197-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11883902

Title: Functional consequences of the G235R mutation in liver arginase leading to hyperargininemia.

PubMed ID: 11883902

DOI: 10.1006/abbi.2001.2720

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 8849731

Title: Structure of a unique binuclear manganese cluster in arginase.

PubMed ID: 8849731

DOI: 10.1038/383554a0

PubMed ID: 9265637

Title: Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.

PubMed ID: 9265637

DOI: 10.1021/bi970800v

PubMed ID: 10542097

Title: Arginase-boronic acid complex highlights a physiological role in erectile function.

PubMed ID: 10542097

DOI: 10.1038/14929

PubMed ID: 12820884

Title: Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I.

PubMed ID: 12820884

DOI: 10.1021/bi030074y

PubMed ID: 15315440

Title: Design of amino acid aldehydes as transition-state analogue inhibitors of arginase.

PubMed ID: 15315440

DOI: 10.1021/ja047788w

PubMed ID: 16266687

Title: Probing the role of the hyper-reactive histidine residue of arginase.

PubMed ID: 16266687

DOI: 10.1016/j.abb.2005.09.009

Sequence Information:

Length: 323
Mass: 34973
Checksum: 5A92CB0931F9A053
Sequence:

MSSKPKPIEI IGAPFSKGQP RGGVEKGPAA LRKAGLVEKL KETEYNVRDH GDLAFVDVPN 
DSPFQIVKNP RSVGKANEQL AAVVAETQKN GTISVVLGGD HSMAIGSISG HARVHPDLCV 
IWVDAHTDIN TPLTTSSGNL HGQPVAFLLK ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR 
DVDPGEHYII KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPVF 
TPATGTPVVG GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTPEEVT RTVNTAVALT 
LSCFGTKREG NHKPETDYLK PPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arg1

Associated with

Other Information

Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase. PubMed ID: 3571256

Structural organization of the gene for rat liver-type arginase. PubMed ID: 2892837

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional consequences of the G235R mutation in liver arginase leading to hyperargininemia. PubMed ID: 11883902

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Structure of a unique binuclear manganese cluster in arginase. PubMed ID: 8849731

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function. PubMed ID: 9265637

Arginase-boronic acid complex highlights a physiological role in erectile function. PubMed ID: 10542097

Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I. PubMed ID: 12820884

Design of amino acid aldehydes as transition-state analogue inhibitors of arginase. PubMed ID: 15315440

Probing the role of the hyper-reactive histidine residue of arginase. PubMed ID: 16266687