Penk | ENSRNOG00000008943 | NCBI 29237

Details for: Penk

Gene ID: 29237

Symbol: Penk

Ensembl ID: ENSRNOG00000008943

Description: proenkephalin

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (i) signalling events
(R-RNO-418594)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Metabolism of proteins
(R-RNO-392499)
Peptide ligand-binding receptors
(R-RNO-375276)
Post-translational protein modification
(R-RNO-597592)
Post-translational protein phosphorylation
(R-RNO-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-RNO-381426)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Aggressive behavior
(GO:0002118)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Behavioral fear response
(GO:0001662)
Cell body fiber
(GO:0070852)
Cellular response to camp
(GO:0071320)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to virus
(GO:0098586)
Cellular response to vitamin d
(GO:0071305)
Chemical synaptic transmission
(GO:0007268)
Chromaffin granule lumen
(GO:0034466)
Dendrite
(GO:0030425)
Extracellular region
(GO:0005576)
General adaptation syndrome, behavioral process
(GO:0051867)
Glial cell proliferation
(GO:0014009)
G protein-coupled opioid receptor signaling pathway
(GO:0038003)
Locomotory behavior
(GO:0007626)
Locomotory exploration behavior
(GO:0035641)
Neuronal cell body
(GO:0043025)
Neuronal dense core vesicle lumen
(GO:0099013)
Neuropeptide signaling pathway
(GO:0007218)
Opioid peptide activity
(GO:0001515)
Opioid receptor binding
(GO:0031628)
Osteoblast differentiation
(GO:0001649)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of behavioral fear response
(GO:2000987)
Receptor ligand activity
(GO:0048018)
Regulation of long-term synaptic depression
(GO:1900452)
Response to bacterium
(GO:0009617)
Response to calcium ion
(GO:0051592)
Response to epinephrine
(GO:0071871)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to immobilization stress
(GO:0035902)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Response to toxic substance
(GO:0009636)
Sensory perception
(GO:0007600)
Sensory perception of pain
(GO:0019233)
Startle response
(GO:0001964)
Symmetric synapse
(GO:0032280)
Synaptic signaling via neuropeptide
(GO:0099538)
Synaptic vesicle lumen
(GO:0034592)
Transmission of nerve impulse
(GO:0019226)

Other Information

Proteins

Proenkephalin-A

Genular Protein ID: 3037047734

Symbol: PENK_RAT

Name: Proenkephalin-A

UniProtKB Accession Codes:

P04094 Q53X05

Database IDs:

Citations:

PubMed ID: 6548748

Title: Rat brain preproenkephalin mRNA. cDNA cloning, primary structure, and distribution in the central nervous system.

PubMed ID: 6548748

DOI: 10.1016/s0021-9258(18)89893-3

PubMed ID: 6094550

Title: Isolation and characterization of the rat proenkephalin gene.

PubMed ID: 6094550

DOI: 10.1016/s0021-9258(18)89894-5

PubMed ID: 6594709

Title: Molecular cloning and sequence determination of rat preproenkephalin cDNA: sensitive probe for studying transcriptional changes in rat tissues.

PubMed ID: 6594709

DOI: 10.1073/pnas.81.23.7651

PubMed ID: 3093884

Title: Proenkephalin biosynthesis in the rat.

PubMed ID: 3093884

PubMed ID: 2707437

Title: A new species of enkephalin precursor mRNA with a distinct 5'-untranslated region in haploid germ cells.

PubMed ID: 2707437

DOI: 10.1016/0014-5793(89)80281-9

PubMed ID: 1438982

Title: Molecular cloning, sequence analysis and translation of proenkephalin mRNA from rat heart.

PubMed ID: 1438982

DOI: 10.1016/0167-0115(92)90526-z

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19164277

Title: Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.

PubMed ID: 19164277

DOI: 10.1074/mcp.m800501-mcp200

PubMed ID: 20487892

Title: Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes.

PubMed ID: 20487892

DOI: 10.1016/0197-0186(82)90081-x

PubMed ID: 8624732

Title: The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores.

PubMed ID: 8624732

DOI: 10.1016/0006-8993(95)00928-j

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 269
Mass: 30932
Checksum: 2BF0EA81A1D59692
Sequence:

MAQFLRLCIW LLALGSCLLA TVQADCSQDC AKCSYRLVRP GDINFLACTL ECEGQLPSFK 
IWETCKDLLQ VSKPEFPWDN IDMYKDSSKQ DESHLLAKKY GGFMKRYGGF MKKMDELYPV 
EPEEEANGGE ILAKRYGGFM KKDADEGDTL ANSSDLLKEL LGTGDNRAKD SHQQESTNND 
EDSTSKRYGG FMRGLKRSPQ LEDEAKELQK RYGGFMRRVG RPEWWMDYQK RYGGFLKRFA 
ESLPSDEEGE SYSKEVPEME KRYGGFMRF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Penk

Associated with

Other Information

Rat brain preproenkephalin mRNA. cDNA cloning, primary structure, and distribution in the central nervous system. PubMed ID: 6548748

Isolation and characterization of the rat proenkephalin gene. PubMed ID: 6094550

Molecular cloning and sequence determination of rat preproenkephalin cDNA: sensitive probe for studying transcriptional changes in rat tissues. PubMed ID: 6594709

Proenkephalin biosynthesis in the rat. PubMed ID: 3093884

A new species of enkephalin precursor mRNA with a distinct 5'-untranslated region in haploid germ cells. PubMed ID: 2707437

Molecular cloning, sequence analysis and translation of proenkephalin mRNA from rat heart. PubMed ID: 1438982

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics. PubMed ID: 19164277

Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes. PubMed ID: 20487892

The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. PubMed ID: 8624732

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903