Polb | ENSRNOG00000019150 | NCBI 29240

Details for: Polb

Gene ID: 29240

Symbol: Polb

Ensembl ID: ENSRNOG00000019150

Description: DNA polymerase beta

Associated with

Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
(R-RNO-73930)
Apex1-independent resolution of ap sites via the single nucleotide replacement pathway
(R-RNO-5649702)
Base excision repair
(R-RNO-73884)
Deubiquitination
(R-RNO-5688426)
Metabolism of proteins
(R-RNO-392499)
Pcna-dependent long patch base excision repair
(R-RNO-5651801)
Polb-dependent long patch base excision repair
(R-RNO-110362)
Post-translational protein modification
(R-RNO-597592)
Resolution of abasic sites (ap sites)
(R-RNO-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-RNO-110373)
Resolution of ap sites via the single-nucleotide replacement pathway
(R-RNO-110381)
Ub-specific processing proteases
(R-RNO-5689880)
5'-deoxyribose-5-phosphate lyase activity
(GO:0051575)
Apoptotic process
(GO:0006915)
Base-excision repair
(GO:0006284)
Base-excision repair, gap-filling
(GO:0006287)
Class i dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0140078)
Cytoplasm
(GO:0005737)
Damaged dna binding
(GO:0003684)
Dna-directed dna polymerase activity
(GO:0003887)
Dna binding
(GO:0003677)
Dna biosynthetic process
(GO:0071897)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Enzyme binding
(GO:0019899)
Homeostasis of number of cells
(GO:0048872)
Immunoglobulin heavy chain v-d-j recombination
(GO:0071707)
Inflammatory response
(GO:0006954)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Lyase activity
(GO:0016829)
Lymph node development
(GO:0048535)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Neuron apoptotic process
(GO:0051402)
Nucleotide-excision repair, dna gap filling
(GO:0006297)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Pyrimidine dimer repair
(GO:0006290)
Response to ethanol
(GO:0045471)
Response to gamma radiation
(GO:0010332)
Response to hyperoxia
(GO:0055093)
Salivary gland morphogenesis
(GO:0007435)
Somatic diversification of immunoglobulins
(GO:0016445)
Somatic hypermutation of immunoglobulin genes
(GO:0016446)
Spindle microtubule
(GO:0005876)
Spleen development
(GO:0048536)

Other Information

Proteins

DPOLB_RAT

Genular Protein ID: 3955396026

Symbol: DPOLB_RAT

Name: N/A

UniProtKB Accession Codes:

P06766 Q4G081

Database IDs:

Citations:

PubMed ID: 3597402

Title: Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase.

PubMed ID: 3597402

DOI: 10.1016/s0021-9258(18)48029-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2873575

Title: Structure of rat DNA polymerase beta revealed by partial amino acid sequencing and cDNA cloning.

PubMed ID: 2873575

DOI: 10.1073/pnas.83.14.5106

PubMed ID: 2404980

Title: Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain.

PubMed ID: 2404980

DOI: 10.1016/s0021-9258(19)39949-1

PubMed ID: 2198936

Title: Site-directed mutagenesis of recombinant rat DNA polymerase beta: involvement of arginine-183 in primer recognition.

PubMed ID: 2198936

DOI: 10.1021/bi00473a005

PubMed ID: 2036395

Title: Aspartic acid residues at positions 190 and 192 of rat DNA polymerase beta are involved in primer binding.

PubMed ID: 2036395

DOI: 10.1021/bi00235a023

PubMed ID: 1420147

Title: Mammalian DNA polymerase beta: characterization of a 16-kDa transdomain fragment containing the nucleic acid-binding activities of the native enzyme.

PubMed ID: 1420147

DOI: 10.1021/bi00157a014

PubMed ID: 14563842

Title: The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site.

PubMed ID: 14563842

DOI: 10.1074/jbc.m309607200

PubMed ID: 8137427

Title: 2.3-A crystal structure of the catalytic domain of DNA polymerase beta.

PubMed ID: 8137427

DOI: 10.1016/0092-8674(94)90388-3

PubMed ID: 7516581

Title: Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.

PubMed ID: 7516581

DOI: 10.1126/science.7516581

PubMed ID: 8841120

Title: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.

PubMed ID: 8841120

DOI: 10.1021/bi960790i

PubMed ID: 11330999

Title: Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.

PubMed ID: 11330999

DOI: 10.1021/bi002176j

PubMed ID: 8639559

Title: Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface.

PubMed ID: 8639559

DOI: 10.1021/bi952656o

PubMed ID: 10656829

Title: Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity.

PubMed ID: 10656829

DOI: 10.1006/jmbi.1999.3455

Sequence Information:

Length: 335
Mass: 38327
Checksum: BBF8498C0D3FBFC9
Sequence:

MSKRKAPQET LNGGITDMLV ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK 
KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVTGIGPSA ARKLVDEGIK 
TLEDLRKNED KLNHHQRIGL KYFEDFEKRI PREEMLQMQD IVLNEVKKLD PEYIATVCGS 
FRRGAESSGD MDVLLTHPNF TSESSKQPKL LHRVVEQLQK VRFITDTLSK GETKFMGVCQ 
LPSENDENEY PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP 
LGVTGVAGEP LPVDSEQDIF DYIQWRYREP KDRSE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Polb

Associated with

Other Information

Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase. PubMed ID: 3597402

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of rat DNA polymerase beta revealed by partial amino acid sequencing and cDNA cloning. PubMed ID: 2873575

Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain. PubMed ID: 2404980

Site-directed mutagenesis of recombinant rat DNA polymerase beta: involvement of arginine-183 in primer recognition. PubMed ID: 2198936

Aspartic acid residues at positions 190 and 192 of rat DNA polymerase beta are involved in primer binding. PubMed ID: 2036395

Mammalian DNA polymerase beta: characterization of a 16-kDa transdomain fragment containing the nucleic acid-binding activities of the native enzyme. PubMed ID: 1420147

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. PubMed ID: 14563842

2.3-A crystal structure of the catalytic domain of DNA polymerase beta. PubMed ID: 8137427

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. PubMed ID: 7516581

Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. PubMed ID: 8841120

Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes. PubMed ID: 11330999

Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. PubMed ID: 8639559

Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. PubMed ID: 10656829