Details for: Adcy8
Associated with
Other Information
Genular Protein ID: 468070045
Symbol: ADCY8_RAT
Name: ATP pyrophosphate-lyase 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8163524
Title: Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.
PubMed ID: 8163524
PubMed ID: 8557635
Title: Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin.
PubMed ID: 8557635
PubMed ID: 11856299
Title: Dimerization of mammalian adenylate cyclases.
PubMed ID: 11856299
PubMed ID: 11744699
Title: Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.
PubMed ID: 11744699
PubMed ID: 13680124
Title: Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.
PubMed ID: 13680124
PubMed ID: 16186630
Title: Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers.
PubMed ID: 16186630
DOI: 10.1385/jmn:27:2:195
PubMed ID: 16741924
Title: PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.
PubMed ID: 16741924
DOI: 10.1002/jcp.20673
PubMed ID: 16258073
Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.
PubMed ID: 16258073
PubMed ID: 19158400
Title: Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.
PubMed ID: 19158400
PubMed ID: 19305019
Title: Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.
PubMed ID: 19305019
PubMed ID: 19171672
Title: Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.
PubMed ID: 19171672
PubMed ID: 20410303
Title: AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.
PubMed ID: 20410303
PubMed ID: 21046358
Title: Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
PubMed ID: 21046358
PubMed ID: 21771783
Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
PubMed ID: 21771783
PubMed ID: 22399809
Title: Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.
PubMed ID: 22399809
DOI: 10.1242/jcs.091090
PubMed ID: 22976297
Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
PubMed ID: 22976297
DOI: 10.1242/jcs.111427
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
DOI: 10.1038/ncomms1871
PubMed ID: 22494970
Title: Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
PubMed ID: 22494970
PubMed ID: 24086669
Title: An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.
PubMed ID: 24086669
PubMed ID: 25381556
Title: Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.
PubMed ID: 25381556
Sequence Information:
- Length: 1248
- Mass: 139823
- Checksum: 0171A3CEED034961
- Sequence:
MELSDVHCLS GSEELYTIHP TPPAADGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH LAQALHVQSG PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK YSQMRDEVFK SNLVCAFIVL LFITAIQSLL PSSRLMPMTI QFSILIMLHS ALVLITTAED YKCLPLILRK TCCWINETYL ARNVIIFASI LINFLGAVIN ILWCDFDKSI PLKNLTFNSS AVFTDICSYP EYFVFTGVLA MVTCAVFLRL NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN ILPGHVARHF LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ GVECLRLLNE IIADFDELLG EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC EDKWGHLCAL ADFSLALTES IQEINKHSFN NFELRIGISH GSVVAGVIGA KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ GFAFDYRGEI YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP
Genular Protein ID: 3718633067
Symbol: A0A8I6GDK4_RAT
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057822
Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
PubMed ID: 15057822
DOI: 10.1038/nature02426
Sequence Information:
- Length: 1218
- Mass: 136372
- Checksum: B54F238CB22847D6
- Sequence:
MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH LAQALHVQSG PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK YSQMRDEVFK SNLVCAFIVL LFITAIQSLL PSSRLMPMTI QFSILIMLHS ALVLITTAED YKCLPLILRK TCCWINETYL ARNVIIFASI LINFLGAVIN IYFVFTGVLA MVTCAVFLRL NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN ILPGHVARHF LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ GVECLRLLNE IIADFDELLG EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC EDKWGHLCAL ADFSLALTES IQEINKHSFN NFELRIGISH GSVVAGVIGA KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ GFAFDYRGEI YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP
Genular Protein ID: 1897327957
Symbol: A0A8I6A3U3_RAT
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057822
Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
PubMed ID: 15057822
DOI: 10.1038/nature02426
Sequence Information:
- Length: 1182
- Mass: 132260
- Checksum: E8465954C844A000
- Sequence:
MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNYSQMRD EVFKSNLVCA FIVLLFITAI QSLLPSSRLM PMTIQFSILI MLHSALVLIT TAEDYKCLPL ILRKTCCWIN ETYLARNVII FASILINFLG AVINILWCDF DKSIPLKNLT FNSSAVFTDI CSYPEYFVFT GVLAMVTCAV FLRLNSVLKL AVLLIMIAIY ALLTETIYAG LFLSYDNLNH SGEDFLGTKE ASLLLMAMFL LAVFYHGQQL EYTARLDFLW RVQAKEEINE MKDLREHNEN MLRNILPGHV ARHFLEKDRD NEELYSQSYD AVGVMFASIP GFADFYSQTE MNNQGVECLR LLNEIIADFD ELLGEDRFQD IEKIKTIGST YMAVSGLSPE KQQCEDKWGH LCALADFSLA LTESIQEINK HSFNNFELRI GISHGSVVAG VIGAKKPQYD IWGKTVNLAS RMDSTGVSGR IQVPEETYLI LKDQGFAFDY RGEIYVKGIS EQEGKIKTYF LLGRVQPNPF ILPPRRLPGQ YSLAAVVLGL VQSLNRQRQK QLLNENSNSG IIKSHYNRRT LLTPSGPEPG AQAEGTDKSD LP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.