Details for: Adcy8

Gene ID: 29241

Symbol: Adcy8

Ensembl ID: ENSRNOG00000004890

Description: adenylate cyclase 8

Associated with

Other Information

Genular Protein ID: 468070045

Symbol: ADCY8_RAT

Name: ATP pyrophosphate-lyase 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8163524

Title: Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.

PubMed ID: 8163524

DOI: 10.1016/s0021-9258(17)32700-x

PubMed ID: 8557635

Title: Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin.

PubMed ID: 8557635

DOI: 10.1074/jbc.271.2.1089

PubMed ID: 11856299

Title: Dimerization of mammalian adenylate cyclases.

PubMed ID: 11856299

DOI: 10.1046/j.0014-2956.2001.02708.x

PubMed ID: 11744699

Title: Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.

PubMed ID: 11744699

DOI: 10.1074/jbc.m109615200

PubMed ID: 13680124

Title: Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.

PubMed ID: 13680124

DOI: 10.1007/s00125-003-1203-8

PubMed ID: 16186630

Title: Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers.

PubMed ID: 16186630

DOI: 10.1385/jmn:27:2:195

PubMed ID: 16741924

Title: PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.

PubMed ID: 16741924

DOI: 10.1002/jcp.20673

PubMed ID: 16258073

Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

PubMed ID: 16258073

DOI: 10.1124/mol.105.018275

PubMed ID: 19158400

Title: Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.

PubMed ID: 19158400

DOI: 10.1152/ajpcell.00488.2008

PubMed ID: 19305019

Title: Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.

PubMed ID: 19305019

DOI: 10.1074/jbc.m809585200

PubMed ID: 19171672

Title: Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.

PubMed ID: 19171672

DOI: 10.1124/mol.108.051748

PubMed ID: 20410303

Title: AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

PubMed ID: 20410303

DOI: 10.1074/jbc.m110.120725

PubMed ID: 21046358

Title: Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.

PubMed ID: 21046358

DOI: 10.1007/s00125-010-1955-x

PubMed ID: 21771783

Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.

PubMed ID: 21771783

DOI: 10.1074/jbc.m111.243899

PubMed ID: 22399809

Title: Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

PubMed ID: 22399809

DOI: 10.1242/jcs.091090

PubMed ID: 22976297

Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

PubMed ID: 22976297

DOI: 10.1242/jcs.111427

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 22494970

Title: Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.

PubMed ID: 22494970

DOI: 10.1126/scisignal.2002299

PubMed ID: 24086669

Title: An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

PubMed ID: 24086669

DOI: 10.1371/journal.pone.0075942

PubMed ID: 25381556

Title: Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.

PubMed ID: 25381556

DOI: 10.1007/s00125-014-3437-z

Sequence Information:

  • Length: 1248
  • Mass: 139823
  • Checksum: 0171A3CEED034961
  • Sequence:
  • MELSDVHCLS GSEELYTIHP TPPAADGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG 
    GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG 
    GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV 
    VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ 
    YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ 
    VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL 
    ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF 
    TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV 
    EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG 
    GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK 
    ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH LAQALHVQSG 
    PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK YSQMRDEVFK SNLVCAFIVL 
    LFITAIQSLL PSSRLMPMTI QFSILIMLHS ALVLITTAED YKCLPLILRK TCCWINETYL 
    ARNVIIFASI LINFLGAVIN ILWCDFDKSI PLKNLTFNSS AVFTDICSYP EYFVFTGVLA 
    MVTCAVFLRL NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL 
    LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN ILPGHVARHF 
    LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ GVECLRLLNE IIADFDELLG 
    EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC EDKWGHLCAL ADFSLALTES IQEINKHSFN 
    NFELRIGISH GSVVAGVIGA KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ 
    GFAFDYRGEI YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL 
    NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP

Genular Protein ID: 3718633067

Symbol: A0A8I6GDK4_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 1218
  • Mass: 136372
  • Checksum: B54F238CB22847D6
  • Sequence:
  • MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG 
    GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG 
    GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV 
    VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ 
    YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ 
    VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL 
    ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF 
    TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV 
    EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG 
    GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK 
    ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH LAQALHVQSG 
    PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK YSQMRDEVFK SNLVCAFIVL 
    LFITAIQSLL PSSRLMPMTI QFSILIMLHS ALVLITTAED YKCLPLILRK TCCWINETYL 
    ARNVIIFASI LINFLGAVIN IYFVFTGVLA MVTCAVFLRL NSVLKLAVLL IMIAIYALLT 
    ETIYAGLFLS YDNLNHSGED FLGTKEASLL LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA 
    KEEINEMKDL REHNENMLRN ILPGHVARHF LEKDRDNEEL YSQSYDAVGV MFASIPGFAD 
    FYSQTEMNNQ GVECLRLLNE IIADFDELLG EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC 
    EDKWGHLCAL ADFSLALTES IQEINKHSFN NFELRIGISH GSVVAGVIGA KKPQYDIWGK 
    TVNLASRMDS TGVSGRIQVP EETYLILKDQ GFAFDYRGEI YVKGISEQEG KIKTYFLLGR 
    VQPNPFILPP RRLPGQYSLA AVVLGLVQSL NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP 
    SGPEPGAQAE GTDKSDLP

Genular Protein ID: 1897327957

Symbol: A0A8I6A3U3_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 1182
  • Mass: 132260
  • Checksum: E8465954C844A000
  • Sequence:
  • MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG 
    GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG 
    GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV 
    VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ 
    YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ 
    VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL 
    ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF 
    TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV 
    EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG 
    GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK 
    ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNYSQMRD EVFKSNLVCA FIVLLFITAI 
    QSLLPSSRLM PMTIQFSILI MLHSALVLIT TAEDYKCLPL ILRKTCCWIN ETYLARNVII 
    FASILINFLG AVINILWCDF DKSIPLKNLT FNSSAVFTDI CSYPEYFVFT GVLAMVTCAV 
    FLRLNSVLKL AVLLIMIAIY ALLTETIYAG LFLSYDNLNH SGEDFLGTKE ASLLLMAMFL 
    LAVFYHGQQL EYTARLDFLW RVQAKEEINE MKDLREHNEN MLRNILPGHV ARHFLEKDRD 
    NEELYSQSYD AVGVMFASIP GFADFYSQTE MNNQGVECLR LLNEIIADFD ELLGEDRFQD 
    IEKIKTIGST YMAVSGLSPE KQQCEDKWGH LCALADFSLA LTESIQEINK HSFNNFELRI 
    GISHGSVVAG VIGAKKPQYD IWGKTVNLAS RMDSTGVSGR IQVPEETYLI LKDQGFAFDY 
    RGEIYVKGIS EQEGKIKTYF LLGRVQPNPF ILPPRRLPGQ YSLAAVVLGL VQSLNRQRQK 
    QLLNENSNSG IIKSHYNRRT LLTPSGPEPG AQAEGTDKSD LP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.