Gch1 | ENSRNOG00000011039 | NCBI 29244

Details for: Gch1

Gene ID: 29244

Symbol: Gch1

Ensembl ID: ENSRNOG00000011039

Description: GTP cyclohydrolase 1

Associated with

Metabolism
(R-RNO-1430728)
Metabolism of cofactors
(R-RNO-8978934)
Metabolism of vitamins and cofactors
(R-RNO-196854)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-RNO-1474151)
Calcium ion binding
(GO:0005509)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dihydrobiopterin metabolic process
(GO:0051066)
Dopamine biosynthetic process
(GO:0042416)
Gtp-dependent protein binding
(GO:0030742)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Gtp cyclohydrolase i activity
(GO:0003934)
Identical protein binding
(GO:0042802)
Mitochondrion
(GO:0005739)
Mitogen-activated protein kinase binding
(GO:0051019)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cellular senescence
(GO:2000773)
Neuromuscular process controlling posture
(GO:0050884)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein-containing complex
(GO:0032991)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Pteridine-containing compound biosynthetic process
(GO:0042559)
Regulation of blood pressure
(GO:0008217)
Regulation of lung blood pressure
(GO:0014916)
Regulation of removal of superoxide radicals
(GO:2000121)
Response to lipopolysaccharide
(GO:0032496)
Response to pain
(GO:0048265)
Response to tumor necrosis factor
(GO:0034612)
Response to type ii interferon
(GO:0034341)
Tetrahydrobiopterin biosynthetic process
(GO:0006729)
Tetrahydrofolate biosynthetic process
(GO:0046654)
Vasodilation
(GO:0042311)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

GTP cyclohydrolase 1

Genular Protein ID: 4077256204

Symbol: GCH1_RAT

Name: GTP cyclohydrolase 1

UniProtKB Accession Codes:

P22288

Database IDs:

Citations:

PubMed ID: 1985963

Title: Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway.

PubMed ID: 1985963

DOI: 10.1016/s0021-9258(17)35238-9

PubMed ID: 7802677

Title: Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells.

PubMed ID: 7802677

DOI: 10.1006/bbrc.1994.2822

PubMed ID: 2557335

Title: Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme.

PubMed ID: 2557335

DOI: 10.1016/s0021-9258(20)88236-2

PubMed ID: 17057711

Title: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.

PubMed ID: 17057711

DOI: 10.1038/nm1490

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 11818540

Title: Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

PubMed ID: 11818540

DOI: 10.1073/pnas.022646999

Sequence Information:

Length: 241
Mass: 27057
Checksum: 8226E3319816325B
Sequence:

MEKPRGVRCT NGFPERELPR PGASRPAEKS RPPEAKGAQP ADAWKAGRPR SEEDNELNLP 
NLAAAYSSIL RSLGEDPQRQ GLLKTPWRAA TAMQFFTKGY QETISDVLND AIFDEDHDEM 
VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 
AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 
S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gch1

Associated with

Other Information

Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway. PubMed ID: 1985963

Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. PubMed ID: 7802677

Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme. PubMed ID: 2557335

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. PubMed ID: 17057711

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903