Details for: F2

Gene ID: 29251

Symbol: F2

Ensembl ID: ENSRNOG00000016325

Description: coagulation factor II, thrombin

Associated with

  • Cell surface interactions at the vascular wall
    (R-RNO-202733)
  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • Common pathway of fibrin clot formation
    (R-RNO-140875)
  • Complement cascade
    (R-RNO-166658)
  • Formation of fibrin clot (clotting cascade)
    (R-RNO-140877)
  • G alpha (q) signalling events
    (R-RNO-416476)
  • Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    (R-RNO-159854)
  • Gamma-carboxylation of protein precursors
    (R-RNO-159740)
  • Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
    (R-RNO-163841)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Hemostasis
    (R-RNO-109582)
  • Immune system
    (R-RNO-168256)
  • Innate immune system
    (R-RNO-168249)
  • Intrinsic pathway of fibrin clot formation
    (R-RNO-140837)
  • Metabolism of proteins
    (R-RNO-392499)
  • Peptide ligand-binding receptors
    (R-RNO-375276)
  • Platelet activation, signaling and aggregation
    (R-RNO-76002)
  • Platelet aggregation (plug formation)
    (R-RNO-76009)
  • Post-translational protein modification
    (R-RNO-597592)
  • Regulation of complement cascade
    (R-RNO-977606)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-RNO-381426)
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
    (R-RNO-159782)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Thrombin signalling through proteinase activated receptors (pars)
    (R-RNO-456926)
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
    (R-RNO-159763)
  • Acute-phase response
    (GO:0006953)
  • Antimicrobial humoral immune response mediated by antimicrobial peptide
    (GO:0061844)
  • Blood coagulation
    (GO:0007596)
  • Calcium ion binding
    (GO:0005509)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytolysis by host of symbiont cells
    (GO:0051838)
  • Endopeptidase activity
    (GO:0004175)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Fibrinolysis
    (GO:0042730)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Heparin binding
    (GO:0008201)
  • Ligand-gated ion channel signaling pathway
    (GO:1990806)
  • Lipopolysaccharide binding
    (GO:0001530)
  • Negative regulation of astrocyte differentiation
    (GO:0048712)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of proteolysis
    (GO:0045861)
  • Neutrophil-mediated killing of gram-negative bacterium
    (GO:0070945)
  • Peptidase activity
    (GO:0008233)
  • Platelet activation
    (GO:0030168)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:1900738)
  • Positive regulation of protein localization to nucleus
    (GO:1900182)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Proteolysis
    (GO:0006508)
  • Regulation of cell shape
    (GO:0008360)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of gene expression
    (GO:0010468)
  • Response to inactivity
    (GO:0014854)
  • Response to thyroglobulin triiodothyronine
    (GO:1904016)
  • Response to thyrotropin-releasing hormone
    (GO:1905225)
  • Response to thyroxine
    (GO:0097068)
  • Response to wounding
    (GO:0009611)
  • Serine-type endopeptidase activity
    (GO:0004252)
  • Signaling receptor binding
    (GO:0005102)
  • Thrombospondin receptor activity
    (GO:0070053)

Other Information

Genular Protein ID: 4053695581

Symbol: G3V843_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 617
  • Mass: 70386
  • Checksum: 8C11117828B20AC0
  • Sequence:
  • MSHVRGLGLP GCLALAALAS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE 
    CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGLNYHGN 
    VSVTHTGIEC QLWRSRYPHR PDINSTTHPG ADLKENFCRN PDSSTSGPWC YTTDPTVRRE 
    ECSIPVCGQE GRTTVKMTPR SRGSKENLSP PLGECLLERG RLYQGNLAVT TLGSPCLAWD 
    SLPTKTLSKY QNFDPEVKLV QNFCRNPDRD EEGAWCFVAQ QPGFEYCSLN YCDEAVGEEN 
    HDGDESIAGR TTDAEFHTFF DERTFGLGEA DCGLRPLFEK KSLTDKTEKE LLDSYIDGRI 
    VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV 
    RIGKHSRTRY ERNVEKISML EKIYIHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP 
    DKQTVTSLLQ AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI 
    TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT 
    HVFRLKRWMQ KVIDQHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.