Tlr4 | ENSRNOG00000010522 | NCBI 29260

Details for: Tlr4

Gene ID: 29260

Symbol: Tlr4

Ensembl ID: ENSRNOG00000010522

Description: toll-like receptor 4

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-RNO-936964)
Apoptosis
(R-RNO-109581)
Caspase activation via death receptors in the presence of ligand
(R-RNO-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-RNO-5357769)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Heme signaling
(R-RNO-9707616)
Ikk complex recruitment mediated by rip1
(R-RNO-937041)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-RNO-975163)
Myd88 dependent cascade initiated on endosome
(R-RNO-975155)
Myd88-independent tlr4 cascade
(R-RNO-166166)
Programmed cell death
(R-RNO-5357801)
Regulation of tlr by endogenous ligand
(R-RNO-5686938)
Toll-like receptor cascades
(R-RNO-168898)
Toll like receptor 4 (tlr4) cascade
(R-RNO-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-RNO-168181)
Toll like receptor 9 (tlr9) cascade
(R-RNO-168138)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-RNO-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-RNO-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-RNO-937061)
Trif-mediated programmed cell death
(R-RNO-2562578)
Activation of innate immune response
(GO:0002218)
Astrocyte development
(GO:0014002)
B cell proliferation
(GO:0042100)
B cell proliferation involved in immune response
(GO:0002322)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Detection of lipopolysaccharide
(GO:0032497)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Immunoglobulin mediated immune response
(GO:0016064)
Inflammatory response
(GO:0006954)
Innate immune response-activating signaling pathway
(GO:0002758)
Jnk cascade
(GO:0007254)
Leukotriene metabolic process
(GO:0006691)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Macrophage activation
(GO:0042116)
Mhc class ii biosynthetic process
(GO:0045342)
Microglia differentiation
(GO:0014004)
Microglial cell activation
(GO:0001774)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of interleukin-23 production
(GO:0032707)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type ii interferon production
(GO:0032689)
Neurogenesis
(GO:0022008)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide production involved in inflammatory response
(GO:0002537)
Phagocytosis
(GO:0006909)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-1 production
(GO:0032732)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of platelet activation
(GO:0010572)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dendritic cell cytokine production
(GO:0002730)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to activity
(GO:0014823)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to oxidative stress
(GO:0006979)
Response to progesterone
(GO:0032570)
Response to retinoic acid
(GO:0032526)
Response to toxic substance
(GO:0009636)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Skeletal muscle contraction
(GO:0003009)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor signaling pathway
(GO:0002224)
Transmembrane signaling receptor activity
(GO:0004888)
Trif-dependent toll-like receptor signaling pathway
(GO:0035666)
Wound healing involved in inflammatory response
(GO:0002246)

Other Information

Proteins

Toll-like receptor 4
G3V7D8_RAT

Genular Protein ID: 822686646

Symbol: TLR4_RAT

Name: Toll-like receptor 4

UniProtKB Accession Codes:

Q9QX05

Database IDs:

Citations:

PubMed ID: 10430608

Title: Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.

PubMed ID: 10430608

DOI: 10.1172/jci6709

Sequence Information:

Length: 835
Mass: 96072
Checksum: DF5E16A30851E3A0
Sequence:

MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD IPYSTKNLDL 
SFNPLKILRS YSFTNFSQLQ WLDLSRCEIE TIEDKAWHGL NQLSTLVLTG NPIKSFSPGS 
FSGLTNLENL VAVETKMTSL EGFHIGQLIS LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD 
LSYNYIQTIS VKDLQFLREN PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN 
VLKMCLQNMT GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY 
NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF LKSWTLTTNR 
EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK YLDLSFNGVI LMSANFMGLE 
ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL DISYTNTKID FDGIFLGLIS LNTLKMAGNS 
FKDNTLSNVF TNTTNLTFLD LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ 
LYSLRTLDCS FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN 
VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY HFYFHLILIA 
GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR FQLCLHYRDF IPGVAIAANI 
IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ 
VELYRLLSRN TYLEWEDNAL GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT

Genular Protein ID: 3857941298

Symbol: G3V7D8_RAT

Name: N/A

UniProtKB Accession Codes:

G3V7D8

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 835
Mass: 96058
Checksum: C45E4A4A735169B5
Sequence:

MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD IPYSTKNLDL 
SFNPLKILRS YSFSNFSQLQ WLDLSRCEIE TIEDKAWHGL NQLSTLVLTG NPIKSFSPGS 
FSGLTNLENL VAVETKMTSL EGFHIGQLIS LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD 
LSYNYIQTIS VKDLQFLREN PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN 
VLKMCLQNMT GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY 
NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF LKSWTLTTNR 
EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK YLDLSFNGVI LMSANFMGLE 
ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL DISYTNTKID FDGIFLGLIS LNTLKMAGNS 
FKDNTLSNVF TNTTNLTFLD LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ 
LYSLRTLDCS FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN 
VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY HFYFHLILIA 
GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR FQLCLHYRDF IPGVAIAANI 
IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ 
VELYRLLSRN TYLEWEDNAL GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.