Tyms | ENSRNOG00000037225 | NCBI 29261

Details for: Tyms

Gene ID: 29261

Symbol: Tyms

Ensembl ID: ENSRNOG00000037225

Description: thymidylate synthetase

Associated with

Interconversion of nucleotide di- and triphosphates
(R-RNO-499943)
Metabolism
(R-RNO-1430728)
Metabolism of nucleotides
(R-RNO-15869)
Cartilage development
(GO:0051216)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Developmental growth
(GO:0048589)
Dtmp biosynthetic process
(GO:0006231)
Dttp biosynthetic process
(GO:0006235)
Folic acid binding
(GO:0005542)
Heterocyclic compound binding
(GO:1901363)
Intestinal epithelial cell maturation
(GO:0060574)
Liver regeneration
(GO:0097421)
Methylation
(GO:0032259)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Mrna binding
(GO:0003729)
Mrna regulatory element binding translation repressor activity
(GO:0000900)
Negative regulation of translation
(GO:0017148)
Nucleus
(GO:0005634)
Protein homodimerization activity
(GO:0042803)
Pyrimidine nucleobase metabolic process
(GO:0006206)
Regulation of translation
(GO:0006417)
Response to cytokine
(GO:0034097)
Response to ethanol
(GO:0045471)
Response to folic acid
(GO:0051593)
Response to glucocorticoid
(GO:0051384)
Response to organic cyclic compound
(GO:0014070)
Response to organophosphorus
(GO:0046683)
Response to progesterone
(GO:0032570)
Response to toxic substance
(GO:0009636)
Response to vitamin a
(GO:0033189)
Response to xenobiotic stimulus
(GO:0009410)
Sequence-specific mrna binding
(GO:1990825)
Tetrahydrofolate interconversion
(GO:0035999)
Tetrahydrofolate metabolic process
(GO:0046653)
Thymidylate synthase activity
(GO:0004799)
Uracil metabolic process
(GO:0019860)

Other Information

Proteins

Thymidylate synthase

Genular Protein ID: 2270920838

Symbol: TYSY_RAT

Name: Thymidylate synthase

UniProtKB Accession Codes:

P45352 A0JN23

Database IDs:

Citations:

PubMed ID: 7711067

Title: Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.

PubMed ID: 7711067

DOI: 10.1016/0167-4781(95)00008-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9894005

Title: Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.

PubMed ID: 9894005

DOI: 10.1021/bi981881d

Sequence Information:

Length: 307
Mass: 35017
Checksum: 159F564D347B2B52
Sequence:

MLVEGSELQS GAQQPRTEAP QHGELQYLRQ VEHIMRCGFK KEDRTGTGTL SVFGMQARYS 
LRDEFPLLTT KRVFWKGVLE ELLWFIKGST NAKELSSKGV RIWDANGSRD FLDSLGFSAR 
QEGDLGPVYG FQWRHFGADY KDMDSDYSGQ GVDQLQKVID TIKTNPDDRR IIMCAWNPKD 
LPLMALPPCH ALCQFYVVNG ELSCQLYQRS GDMGLGVPFN IASYALLTYM IAHITGLQPG 
DFVHTLGDAH IYLNHIEPLK IQLQREPRPF PKLRILRKVE TIDDFKVEDF QIEGYNPHPT 
IKMEMAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.