Itgb3 | ENSRNOG00000048449 | NCBI 29302

Details for: Itgb3

Gene ID: 29302

Symbol: Itgb3

Ensembl ID: ENSRNOG00000048449

Description: integrin subunit beta 3

Associated with

Axon guidance
(R-RNO-422475)
Cell surface interactions at the vascular wall
(R-RNO-202733)
Developmental biology
(R-RNO-1266738)
Ecm proteoglycans
(R-RNO-3000178)
Elastic fibre formation
(R-RNO-1566948)
Extracellular matrix organization
(R-RNO-1474244)
Grb2:sos provides linkage to mapk signaling for integrins
(R-RNO-354194)
Hemostasis
(R-RNO-109582)
Integrin cell surface interactions
(R-RNO-216083)
Integrin signaling
(R-RNO-354192)
L1cam interactions
(R-RNO-373760)
Map2k and mapk activation
(R-RNO-5674135)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Molecules associated with elastic fibres
(R-RNO-2129379)
Nervous system development
(R-RNO-9675108)
Non-integrin membrane-ecm interactions
(R-RNO-3000171)
P130cas linkage to mapk signaling for integrins
(R-RNO-372708)
Pecam1 interactions
(R-RNO-210990)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet aggregation (plug formation)
(R-RNO-76009)
Platelet degranulation
(R-RNO-114608)
Raf/map kinase cascade
(R-RNO-5673001)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signaling by vegf
(R-RNO-194138)
Signal transduction
(R-RNO-162582)
Signal transduction by l1
(R-RNO-445144)
Syndecan interactions
(R-RNO-3000170)
Tgf-beta receptor signaling activates smads
(R-RNO-2173789)
Vegfa-vegfr2 pathway
(R-RNO-4420097)
Apolipoprotein a-i-mediated signaling pathway
(GO:0038027)
Apoptotic cell clearance
(GO:0043277)
C-x3-c chemokine binding
(GO:0019960)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell-substrate junction assembly
(GO:0007044)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell adhesion molecule binding
(GO:0050839)
Cell migration
(GO:0016477)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Embryo implantation
(GO:0007566)
Enzyme binding
(GO:0019899)
Extracellular matrix binding
(GO:0050840)
Fibrinogen binding
(GO:0070051)
Fibroblast growth factor binding
(GO:0017134)
Fibronectin binding
(GO:0001968)
Heterotypic cell-cell adhesion
(GO:0034113)
Identical protein binding
(GO:0042802)
Insulin-like growth factor i binding
(GO:0031994)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Mesodermal cell differentiation
(GO:0048333)
Metal ion binding
(GO:0046872)
Negative chemotaxis
(GO:0050919)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of lipoprotein metabolic process
(GO:0050748)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Neuregulin binding
(GO:0038132)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Platelet activation
(GO:0030168)
Platelet aggregation
(GO:0070527)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein disulfide isomerase activity
(GO:0003756)
Protein kinase c binding
(GO:0005080)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of protein localization
(GO:0032880)
Regulation of release of sequestered calcium ion into cytosol
(GO:0051279)
Regulation of serotonin uptake
(GO:0051611)
Response to activity
(GO:0014823)
Response to platelet-derived growth factor
(GO:0036119)
Smooth muscle cell migration
(GO:0014909)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Symbiont entry into host cell
(GO:0046718)
Vascular endothelial growth factor receptor 2 binding
(GO:0043184)

Other Information

Proteins

ITB3_RAT

Genular Protein ID: 3339557055

Symbol: ITB3_RAT

Name: N/A

UniProtKB Accession Codes:

Q8R2H2 M0RCF3

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 18549786

Title: Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins.

PubMed ID: 18549786

DOI: 10.1016/j.neuron.2008.04.011

PubMed ID: 18317590

Title: Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.

PubMed ID: 18317590

DOI: 10.1172/jci33374

Sequence Information:

Length: 787
Mass: 86930
Checksum: C67826118411FE95
Sequence:

MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW CSDESLPQNS 
PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG DSAQITQVSP QRIALRLRPD 
DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK DDLSSIQTLG TKLASQMRKL TSNLRIGFGA 
FVDKPVSPYM FISPPQAIKN PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN 
RDAPEGGFDA IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI 
GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI PGTTVGVLSD 
DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CVGLKIGDTV 
SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF 
ECGVCRCDQG WLGSMCECSE EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK 
ITGKYCECDD FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC 
SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL HEENNCNRFC 
RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG RAVLYVVEEP ECPKGPDILV 
VLLSVMGAIL LIGLATLLIW KLLITIHDRK EFAKFEEERA RAKWDTANNP LYKEATSTFT 
NITYRGT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.