Details for: Plcg2

Gene ID: 29337

Symbol: Plcg2

Ensembl ID: ENSRNOG00000051986

Description: phospholipase C, gamma 2

Associated with

  • Antifungal innate immune response
    (GO:0061760)
  • B cell differentiation
    (GO:0030183)
  • B cell receptor signaling pathway
    (GO:0050853)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell activation
    (GO:0001775)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to lectin
    (GO:1990858)
  • Cellular response to lipid
    (GO:0071396)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Follicular b cell differentiation
    (GO:0002316)
  • Inositol trisphosphate biosynthetic process
    (GO:0032959)
  • Intracellular signal transduction
    (GO:0035556)
  • Intracellular vesicle
    (GO:0097708)
  • Lipopolysaccharide-mediated signaling pathway
    (GO:0031663)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Membrane raft
    (GO:0045121)
  • Negative regulation of programmed cell death
    (GO:0043069)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Phosphatidylinositol-mediated signaling
    (GO:0048015)
  • Phosphatidylinositol biosynthetic process
    (GO:0006661)
  • Phosphatidylinositol metabolic process
    (GO:0046488)
  • Phosphatidylinositol phospholipase c activity
    (GO:0004435)
  • Phospholipid catabolic process
    (GO:0009395)
  • Phosphorylation-dependent protein binding
    (GO:0140031)
  • Phosphotyrosine residue binding
    (GO:0001784)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of calcium-mediated signaling
    (GO:0050850)
  • Positive regulation of cell cycle g1/s phase transition
    (GO:1902808)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dendritic cell cytokine production
    (GO:0002732)
  • Positive regulation of epithelial cell migration
    (GO:0010634)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of i-kappab phosphorylation
    (GO:1903721)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of neuroinflammatory response
    (GO:0150078)
  • Positive regulation of nlrp3 inflammasome complex assembly
    (GO:1900227)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of reactive oxygen species biosynthetic process
    (GO:1903428)
  • Positive regulation of receptor internalization
    (GO:0002092)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type i interferon production
    (GO:0032481)
  • Programmed cell death
    (GO:0012501)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein tyrosine kinase binding
    (GO:1990782)
  • Regulation of calcineurin-nfat signaling cascade
    (GO:0070884)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to atp
    (GO:0033198)
  • Response to axon injury
    (GO:0048678)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to magnesium ion
    (GO:0032026)
  • Response to yeast
    (GO:0001878)
  • Ruffle membrane
    (GO:0032587)
  • Scaffold protein binding
    (GO:0097110)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • T cell receptor signaling pathway
    (GO:0050852)
  • Toll-like receptor signaling pathway
    (GO:0002224)

Other Information

Genular Protein ID: 3670078511

Symbol: PLCG2_RAT

Name: Phosphoinositide phospholipase C-gamma-2

UniProtKB Accession Codes:

P24135

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 CDD 8 CTD 1 ChEBI 6 ChEMBL 1 EC 1 EMBL 1 EvolutionaryTrace 1 GO 67 Gene3D 5 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 6 PaxDb 1 Pfam 5 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 10 RefSeq 1 Rhea 2 SMART 6 SMR 1 STRING 1 SUPFAM 6 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2557343

Title: A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity.

PubMed ID: 2557343

DOI: 10.1016/s0021-9258(20)88267-2

PubMed ID: 10498607

Title: Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.

PubMed ID: 10498607

Sequence Information:

  • Length: 1265
  • Mass: 147735
  • Checksum: 2C34910D43572723
  • Sequence:
    • MTTMVNVDTL PEYEKSQIKR ALELGTVMTV FSARKSTPER RTVQMIMETR QVAWSKTADK 
IEGFLDIMEI KEIRPGKNSK DFERAKAVRH KADCCFTIFY GTQFVLSTLS LATDSKEDAV 
KWLSGLKILH QEAMNASTPT MIESWLRKQI YSVDQTRRNS ISLRELKTIL PLVNFKVSGI 
KFLKDKLVEI GAQKDELSFE QFHLFYKKLM FEQQKSILDE FKKDSSVFIL GNTDRPDASA 
VYLQDFQRFL LHEQQELWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS 
IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES STEAYIRCLR AGCRCIELDC 
WDGPDGKPII YHGWTRTTKI KFDDVVQAIR DHAFVTSSFP VILSIEEHCS VEQQRHMAKV 
FKEVLGDLLL TKPTEASADQ LPSPSQLREK IIIKHKKLGP RGDVDVNVED KKDEHKTQGE 
LYMWDSIDQK WTRHYCAIAD AKLSFSDDIE QTVEEDPVQD TPPTELHFGE KWFHKKVESR 
TSAEKLLQEY CAETGAKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMEGGVMKYY 
LTDNLTFNSI YALIQHYREA HLRCAEFELR LTDPVPNPNP HESKPWYYDR LSRGEAEDML 
MRIPRDGAFL IRKREGTDSY AITFRARGKV KHCRINRDGR HFVLGTSAYF ESLVELVSYY 
EKHALYRKMR LRYPVTPELL ERYNMERDIN SLYDVSRMYV DPSEINPSMP QRTVKALYDY 
KAKRSDELTF CRGALIHNVS KEPGGWWKGD YGTRIQQYFP SNYVEDISAG DAEEMEKQII 
EDNPLGSLCR GILDLNTYNV VKAPQGKNQK AFVFILEPKK QGDPPVEFAT DRVEELFEWF 
QSIREITWKI DTKENNMKYW ERNQSIAIEL SDLVVYCKPT SKTKDHLENP DFREIRSFVE 
TKADSIVRQK PVDLLRYNQK GLTRVYPKGQ RVDSSNYDPF RLWLCGSQMV ALNFQTPDKY 
MQMNHALFSL NGRTGYVLQP ESMRSEKYDP MPPESQRKIL MTLTVKVLGA RHLPKLGRSI 
ACPFVEVEIC GAEYDSNKFK TTVVNDNGLS PVWAPTQEKV TFEIYDPNLA FLRFLVYEED 
MFSDPNFLAH ATYPIKGIKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC 
RQLRRRQEEL NNQLFLYDTH QNLRGANRDA LVKEFNVNEN QLRLYQEKCN RRLREKRVSN 
SRFYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.