Smad2 | ENSRNOG00000018140 | NCBI 29357

Details for: Smad2

Gene ID: 29357

Symbol: Smad2

Ensembl ID: ENSRNOG00000018140

Description: SMAD family member 2

Associated with

Deubiquitination
(R-RNO-5688426)
Developmental biology
(R-RNO-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-RNO-2173795)
Downregulation of tgf-beta receptor signaling
(R-RNO-2173788)
Foxo-mediated transcription
(R-RNO-9614085)
Foxo-mediated transcription of cell cycle genes
(R-RNO-9617828)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Rna polymerase ii transcription
(R-RNO-73857)
Signaling by activin
(R-RNO-1502540)
Signaling by nodal
(R-RNO-1181150)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signal transduction
(R-RNO-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-RNO-2173796)
Tgf-beta receptor signaling activates smads
(R-RNO-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-RNO-2173793)
Ub-specific processing proteases
(R-RNO-5689880)
Activin receptor signaling pathway
(GO:0032924)
Adrenal gland development
(GO:0030325)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior pattern specification
(GO:0009952)
Aortic valve morphogenesis
(GO:0003180)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cell population proliferation
(GO:0008283)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Co-smad binding
(GO:0070410)
Determination of left/right asymmetry in lateral mesoderm
(GO:0003140)
Developmental growth
(GO:0048589)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic foregut morphogenesis
(GO:0048617)
Embryonic pattern specification
(GO:0009880)
Endocardial cushion morphogenesis
(GO:0003203)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Gastrulation
(GO:0007369)
Heart development
(GO:0007507)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Insulin secretion
(GO:0030073)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Lung development
(GO:0030324)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Nodal signaling pathway
(GO:0038092)
Nucleus
(GO:0005634)
Odontoblast differentiation
(GO:0071895)
Organ growth
(GO:0035265)
Pancreas development
(GO:0031016)
Paraxial mesoderm morphogenesis
(GO:0048340)
Pattern specification process
(GO:0007389)
Pericardium development
(GO:0060039)
Phosphatase binding
(GO:0019902)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to cholesterol
(GO:0070723)
Response to glucose
(GO:0009749)
Response to transforming growth factor beta
(GO:0071559)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Secondary palate development
(GO:0062009)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Smad binding
(GO:0046332)
Smad protein signal transduction
(GO:0060395)
Tau protein binding
(GO:0048156)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Zygotic specification of dorsal/ventral axis
(GO:0007352)

Other Information

Proteins

Genular Protein ID: 39993991

Symbol: SMAD2_RAT

Name: Mothers against decapentaplegic homolog 2

UniProtKB Accession Codes:

O70436 A0JPM1

Database IDs:

Citations:

PubMed ID: 10382592

Title: Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A.

PubMed ID: 10382592

DOI: 10.1007/s001250051220

PubMed ID: 10670756

Title: cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes.

PubMed ID: 10670756

DOI: 10.1507/endocrj.46.695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

Sequence Information:

Length: 467
Mass: 52239
Checksum: 3A775444411F6619
Sequence:

MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 
LEKAITTQNC NTKCVTIPST CSEIWGLSTA NTVDQWDTTG LYSFSEQTRS LDGRLQVSHR 
KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFSLKKDEV CVNPYHYQRV ETPVLPPVLV 
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 
MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 
NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 
GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

Genular Protein ID: 240695233

Symbol: A0A0G2K0P2_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2K0P2

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 437
Mass: 48929
Checksum: 05FA04A207BFFA6E
Sequence:

MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 
LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE 
YAFSLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI PENTNFPAGI 
EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE 
PAFWCSIAYY ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR 
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF 
AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD 
KVLTQMGSPS VRCSSMS

Genular Protein ID: 524412790

Symbol: A0A8I5ZQC4_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8I5ZQC4

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 411
Mass: 46291
Checksum: 84982F7E00FB472C
Sequence:

MQSTDANCSS LFKESPSNCC RTSTCSEIWG LSTANTVDQW DTTGLYSFSE QTRSLDGRLQ 
VSHRKGLPHV IYCRLWRWPD LHSHHELKAI ENCEYAFSLK KDEVCVNPYH YQRVETPVLP 
PVLVPRHTEI LTELPPLDDY THSIPENTNF PAGIEPQSNY IPETPPPGYI SEDGETSDQQ 
LNQSMDTGSP AELSPTTLSP VNHSLDLQPV TYSEPAFWCS IAYYELNQRV GETFHASQPS 
LTVDGFTDPS NSERFCLGLL SNVNRNATVE MTRRHIGRGV RLYYIGGEVF AECLSDSAIF 
VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ SVNQGFEAVY QLTRMCTIRM 
SFVKGWGAEY RRQTVTSTPC WIELHLNGPL QWLDKVLTQM GSPSVRCSSM S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad2

Associated with

Other Information

Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A. PubMed ID: 10382592

cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes. PubMed ID: 10670756

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. PubMed ID: 21791611

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Database document:

PubMed ID: 10382592

PubMed ID: 10670756

PubMed ID: 15489334

PubMed ID: 21791611

PubMed ID: 15057822

PubMed ID: 15057822