Bace1 | ENSRNOG00000016847 | NCBI 29392

Details for: Bace1

Gene ID: 29392

Symbol: Bace1

Ensembl ID: ENSRNOG00000016847

Description: beta-secretase 1

Associated with

Amyloid-beta binding
(GO:0001540)
Amyloid-beta formation
(GO:0034205)
Amyloid-beta metabolic process
(GO:0050435)
Amyloid precursor protein catabolic process
(GO:0042987)
Aspartic-type endopeptidase activity
(GO:0004190)
Axon
(GO:0030424)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to copper ion
(GO:0071280)
Cellular response to manganese ion
(GO:0071287)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Dendrite
(GO:0030425)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
Early endosome
(GO:0005769)
Endopeptidase activity
(GO:0004175)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Enzyme binding
(GO:0019899)
Golgi apparatus
(GO:0005794)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Late endosome
(GO:0005770)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane raft
(GO:0045121)
Modulation of chemical synaptic transmission
(GO:0050804)
Multivesicular body
(GO:0005771)
Neuronal cell body
(GO:0043025)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of neuron apoptotic process
(GO:0043525)
Prepulse inhibition
(GO:0060134)
Presynapse
(GO:0098793)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Recycling endosome
(GO:0055037)
Response to lead ion
(GO:0010288)
Signaling receptor ligand precursor processing
(GO:0140448)
Synaptic vesicle
(GO:0008021)
Trans-golgi network
(GO:0005802)

Other Information

Proteins

Beta-secretase 1

Genular Protein ID: 3785095882

Symbol: BACE1_RAT

Name: Beta-secretase 1

UniProtKB Accession Codes:

P56819

Database IDs:

Citations:

PubMed ID: 10531052

Title: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

PubMed ID: 10531052

DOI: 10.1126/science.286.5440.735

Sequence Information:

Length: 501
Mass: 55807
Checksum: 24B445BC8BE87DE3
Sequence:

MAPALRWLLL WVGSGMLPAQ GTHLGIRLPL RSGLAGPPLG LRLPRETDEE PEEPGRRGSF 
VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST 
YRDLRKSVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL 
GLAYAEIARP DDSLEPFFDS LVKQTHIPNI FSLQLCGAGF PLNQTEALAS VGGSMIIGGI 
DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK 
VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT 
ILPQQYLRPV EDVATSQDDC YKFAVSQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC 
HVHDEFRTAA VEGPFVTADM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW 
RCLRCLRHQH DDFADDISLL K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bace1

Associated with

Other Information

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. PubMed ID: 10531052

Database document:

PubMed ID: 10531052