Details for: Adra1d

Gene ID: 29413

Symbol: Adra1d

Ensembl ID: ENSRNOG00000021256

Description: adrenoceptor alpha 1D

Associated with

  • Adrenoceptors
    (R-RNO-390696)
  • Amine ligand-binding receptors
    (R-RNO-375280)
  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • G alpha (12/13) signalling events
    (R-RNO-416482)
  • G alpha (q) signalling events
    (R-RNO-416476)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Adenylate cyclase-activating adrenergic receptor signaling pathway
    (GO:0071880)
  • Adrenergic receptor signaling pathway
    (GO:0071875)
  • Alpha1-adrenergic receptor activity
    (GO:0004937)
  • Cell-cell signaling
    (GO:0007267)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
    (GO:0001986)
  • Neuron-glial cell signaling
    (GO:0150099)
  • Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
    (GO:0001994)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Regulation of blood pressure
    (GO:0008217)

Other Information

Genular Protein ID: 1146267420

Symbol: ADA1D_RAT

Name: Alpha-1D adrenergic receptor

UniProtKB Accession Codes:

P23944 Q71UM4

Database IDs:

AGR 1 AlphaFoldDB 1 BindingDB 1 CTD 1 ChEMBL 1 DrugCentral 1 EMBL 3 GO 12 Gene3D 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 3 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 1706716

Title: Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

PubMed ID: 1706716

DOI: 10.1016/s0021-9258(18)38126-2

PubMed ID: 1661838

Title: Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA.

PubMed ID: 1661838

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 10570042

Title: Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP-2-like protein binding to alpha1D proximal promoter region.

PubMed ID: 10570042

DOI: 10.1124/mol.56.6.1152

Sequence Information:

  • Length: 561
  • Mass: 59354
  • Checksum: B6537DCAD4F7BE27
  • Sequence:
    • MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA VVGTGSGEDN 
QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH 
LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWAFGR TFCDVWAAVD VLCCTASILS 
LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC 
GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI 
HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF 
VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR 
RLWAVYGHHW RASTGDARSD CAPSPRIAPP GAPLALTAHP GAGSADTPET QDSVSSSRKP 
ASALREWRLL GPLQRPTTQL RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA 
EAVICQAYEP GDYSNLRETD I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.