Details for: Hap1

Gene ID: 29430

Symbol: Hap1

Ensembl ID: ENSRNOG00000014819

Description: huntingtin-associated protein 1

Associated with

Other Information

Genular Protein ID: 748780394

Symbol: HAP1_RAT

Name: Huntingtin-associated protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7477378

Title: A huntingtin-associated protein enriched in brain with implications for pathology.

PubMed ID: 7477378

DOI: 10.1038/378398a0

PubMed ID: 9285789

Title: Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.

PubMed ID: 9285789

DOI: 10.1093/hmg/6.9.1519

PubMed ID: 9361024

Title: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.

PubMed ID: 9361024

DOI: 10.1093/hmg/6.13.2205

PubMed ID: 9798945

Title: Association of HAP1 isoforms with a unique cytoplasmic structure.

PubMed ID: 9798945

DOI: 10.1046/j.1471-4159.1998.71052178.x

PubMed ID: 9454836

Title: Interaction of huntingtin-associated protein with dynactin P150Glued.

PubMed ID: 9454836

DOI: 10.1523/jneurosci.18-04-01261.1998

PubMed ID: 9742138

Title: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.

PubMed ID: 9742138

DOI: 10.1523/jneurosci.18-19-07674.1998

PubMed ID: 10924259

Title: Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth.

PubMed ID: 10924259

DOI: 10.1006/mcne.2000.0858

PubMed ID: 12021262

Title: Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.

PubMed ID: 12021262

DOI: 10.1074/jbc.m111612200

PubMed ID: 12890790

Title: Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.

PubMed ID: 12890790

DOI: 10.1523/jneurosci.23-17-06956.2003

PubMed ID: 12873381

Title: Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.

PubMed ID: 12873381

DOI: 10.1016/s0896-6273(03)00366-0

PubMed ID: 15242649

Title: Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.

PubMed ID: 15242649

DOI: 10.1016/j.cell.2004.06.018

PubMed ID: 16782802

Title: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.

PubMed ID: 16782802

DOI: 10.1093/hmg/ddl156

PubMed ID: 16339760

Title: Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons.

PubMed ID: 16339760

DOI: 10.1074/jbc.m509806200

PubMed ID: 16738245

Title: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.

PubMed ID: 16738245

DOI: 10.1523/jneurosci.1251-06.2006

PubMed ID: 17166838

Title: 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.

PubMed ID: 17166838

DOI: 10.1074/jbc.m609057200

PubMed ID: 19996106

Title: Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.

PubMed ID: 19996106

DOI: 10.1074/jbc.m109.073197

PubMed ID: 20152113

Title: Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

PubMed ID: 20152113

DOI: 10.1016/j.neuron.2009.12.007

PubMed ID: 21357693

Title: Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.

PubMed ID: 21357693

DOI: 10.1074/jbc.m110.195347

PubMed ID: 22731248

Title: Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.

PubMed ID: 22731248

DOI: 10.1111/j.1471-4159.2012.07845.x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23532844

Title: The Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions.

PubMed ID: 23532844

DOI: 10.1074/jbc.m112.420786

Sequence Information:

  • Length: 629
  • Mass: 70213
  • Checksum: C23C5CB57520B574
  • Sequence:
  • MRPKDQVQSS AGDGTGSGDP ATGTPTTQPA ADPAPEPSAE PKPAPAQGTG SGQKSGSRTK 
    TGGSFCRSRI RGDSDAPWTR YIFQGPYGPR ATGLGTGRAE GIWKTPAAYI GRRPGVSGPE 
    RAAFIRELQE ALCPNPLPRK KITEDDIKVM LYLLEEKERD LNTAARIGQS LVKQNSVLME 
    ENNKLETMLG SAREEILHLR KQVNLRDDLL QLYSDSDDDE EDEEDEEEEE GEEEEREGQR 
    DQDQQHDHPY GAPKPPPKAE TLHHCPQLEA LKQKLKLLEE ENDHLREEAS HLDNLEDKEQ 
    MLILECVEQF SEASQQMAEL SEVLVLRLEG YERQQKEITQ LQAEITKLQQ RCQSYGAQTE 
    KLQQQLASEK GVHPESLRAG SHMQDYGSRP RERQEDGKSH RQRSSMPAGS VTHYGYSVPL 
    DALPSFPETL AEELRTSLRK FITDPAYFME RCDTRCREER KKEQGTMPPP PVQDLKPPED 
    FEAPEELVPE EELGAIEEVG TAEDGPAEET EQASEETEAW EEVEPEVDEA TRMNVVVSAL 
    EASGLGPSHL DMKYVLQQLS NWQDAHSKRQ QKQKVVPKDS PAPQQQTNMG GGIVEQQPIV 
    PTQDSQRLEE DRATHSPSAR EEEGPSGAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.