Details for: Hap1
Associated with
Other Information
Genular Protein ID: 748780394
Symbol: HAP1_RAT
Name: Huntingtin-associated protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7477378
Title: A huntingtin-associated protein enriched in brain with implications for pathology.
PubMed ID: 7477378
DOI: 10.1038/378398a0
PubMed ID: 9285789
Title: Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
PubMed ID: 9285789
DOI: 10.1093/hmg/6.9.1519
PubMed ID: 9361024
Title: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
PubMed ID: 9361024
PubMed ID: 9798945
Title: Association of HAP1 isoforms with a unique cytoplasmic structure.
PubMed ID: 9798945
PubMed ID: 9454836
Title: Interaction of huntingtin-associated protein with dynactin P150Glued.
PubMed ID: 9454836
PubMed ID: 9742138
Title: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.
PubMed ID: 9742138
PubMed ID: 10924259
Title: Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth.
PubMed ID: 10924259
PubMed ID: 12021262
Title: Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.
PubMed ID: 12021262
PubMed ID: 12890790
Title: Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.
PubMed ID: 12890790
PubMed ID: 12873381
Title: Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
PubMed ID: 12873381
PubMed ID: 15242649
Title: Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
PubMed ID: 15242649
PubMed ID: 16782802
Title: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.
PubMed ID: 16782802
DOI: 10.1093/hmg/ddl156
PubMed ID: 16339760
Title: Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons.
PubMed ID: 16339760
PubMed ID: 16738245
Title: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.
PubMed ID: 16738245
PubMed ID: 17166838
Title: 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
PubMed ID: 17166838
PubMed ID: 19996106
Title: Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.
PubMed ID: 19996106
PubMed ID: 20152113
Title: Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.
PubMed ID: 20152113
PubMed ID: 21357693
Title: Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.
PubMed ID: 21357693
PubMed ID: 22731248
Title: Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.
PubMed ID: 22731248
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
DOI: 10.1038/ncomms1871
PubMed ID: 23532844
Title: The Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions.
PubMed ID: 23532844
Sequence Information:
- Length: 629
- Mass: 70213
- Checksum: C23C5CB57520B574
- Sequence:
MRPKDQVQSS AGDGTGSGDP ATGTPTTQPA ADPAPEPSAE PKPAPAQGTG SGQKSGSRTK TGGSFCRSRI RGDSDAPWTR YIFQGPYGPR ATGLGTGRAE GIWKTPAAYI GRRPGVSGPE RAAFIRELQE ALCPNPLPRK KITEDDIKVM LYLLEEKERD LNTAARIGQS LVKQNSVLME ENNKLETMLG SAREEILHLR KQVNLRDDLL QLYSDSDDDE EDEEDEEEEE GEEEEREGQR DQDQQHDHPY GAPKPPPKAE TLHHCPQLEA LKQKLKLLEE ENDHLREEAS HLDNLEDKEQ MLILECVEQF SEASQQMAEL SEVLVLRLEG YERQQKEITQ LQAEITKLQQ RCQSYGAQTE KLQQQLASEK GVHPESLRAG SHMQDYGSRP RERQEDGKSH RQRSSMPAGS VTHYGYSVPL DALPSFPETL AEELRTSLRK FITDPAYFME RCDTRCREER KKEQGTMPPP PVQDLKPPED FEAPEELVPE EELGAIEEVG TAEDGPAEET EQASEETEAW EEVEPEVDEA TRMNVVVSAL EASGLGPSHL DMKYVLQQLS NWQDAHSKRQ QKQKVVPKDS PAPQQQTNMG GGIVEQQPIV PTQDSQRLEE DRATHSPSAR EEEGPSGAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.