Rasgrp1 | ENSRNOG00000005404 | NCBI 29434

Details for: Rasgrp1

Gene ID: 29434

Symbol: Rasgrp1

Ensembl ID: ENSRNOG00000005404

Description: RAS guanyl releasing protein 1

Associated with

Activation of ras in b cells
(R-RNO-1169092)
Adaptive immune system
(R-RNO-1280218)
Downstream signaling events of b cell receptor (bcr)
(R-RNO-1168372)
Hemostasis
(R-RNO-109582)
Immune system
(R-RNO-168256)
Integrin signaling
(R-RNO-354192)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet aggregation (plug formation)
(R-RNO-76009)
Raf/map kinase cascade
(R-RNO-5673001)
Rap1 signalling
(R-RNO-392517)
Signaling by the b cell receptor (bcr)
(R-RNO-983705)
Signal transduction
(R-RNO-162582)
B cell activation
(GO:0042113)
B cell proliferation
(GO:0042100)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cytosol
(GO:0005829)
Diacylglycerol binding
(GO:0019992)
Endoplasmic reticulum membrane
(GO:0005789)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Identical protein binding
(GO:0042802)
Inflammatory response to antigenic stimulus
(GO:0002437)
Mast cell degranulation
(GO:0043303)
Natural killer cell activation
(GO:0030101)
Phosphatidylcholine binding
(GO:0031210)
Plasma membrane
(GO:0005886)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of natural killer cell activation
(GO:0032816)
Positive regulation of natural killer cell differentiation
(GO:0032825)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of t cell differentiation in thymus
(GO:0033089)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Ras protein signal transduction
(GO:0007265)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Secretory granule localization
(GO:0032252)
Small gtpase-mediated signal transduction
(GO:0007264)
T cell activation
(GO:0042110)
T cell proliferation
(GO:0042098)
Vesicle transport along microtubule
(GO:0047496)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

RAS guanyl-releasing protein 1

Genular Protein ID: 2268027358

Symbol: GRP1_RAT

Name: RAS guanyl-releasing protein 1

UniProtKB Accession Codes:

Q9R1K8 O88469

Database IDs:

Citations:

PubMed ID: 9789079

Title: A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

PubMed ID: 9789079

DOI: 10.1073/pnas.95.22.13278

PubMed ID: 9582122

Title: RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs.

PubMed ID: 9582122

DOI: 10.1126/science.280.5366.1082

PubMed ID: 11279364

Title: Distribution of ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system.

PubMed ID: 11279364

DOI: 10.1023/a:1007245728751

PubMed ID: 10779365

Title: The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.

PubMed ID: 10779365

PubMed ID: 11738253

Title: Cellular and subcellular localization of Ras guanyl nucleotide-releasing protein in the rat hippocampus.

PubMed ID: 11738253

DOI: 10.1016/s0306-4522(01)00429-8

PubMed ID: 12626538

Title: T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.

PubMed ID: 12626538

DOI: 10.4049/jimmunol.170.6.2877

PubMed ID: 15064353

Title: Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

PubMed ID: 15064353

DOI: 10.1091/mbc.e03-11-0844

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 795
Mass: 90245
Checksum: 14CC12EBBC967C39
Sequence:

MGTLGKAREA PRKPCHGSRA GPKGRLEAKS TNSPLPAQPS LAQITQFRMM VSLGHLAKGA 
SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIIISSA ELLQKLMNLY KDALEKNSPG 
ICLKICYFVR YWITEFWIMF KMDASLTSTM EEFQDLVKAN GEESHCHLID TTQINSRDWS 
RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE 
NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIH VAQKLHQLQN FNTLMAVIGG 
LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSCRNYDNY RRAYGECTHF KIPILGVHLK 
DLISLYEAMP DYLEDGKVNV QKLLALYNHI NELVQLQDVA PPLDANKDLV HLLTLSLDLY 
YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK 
NYDLDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF 
PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRSKSPAV 
STENISSVVP MSTLCPLGTK DLLHAPEEGS FIFQNGEVVD HSEESKDRTI MLLGVSSQKI 
SVRLKRTVAH KTTQTESFPW VGGEMPPGHF VLTSPRKSAQ GALYVHSPAS PCPSPALVRK 
RAFVKWENKE SLIKPKPELH LRLRTYQELE QEVNTLRADN DALKIQLKYA QKQIESLQLG 
KSNHVLAQMD HGDGT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rasgrp1

Associated with

Other Information

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. PubMed ID: 9789079

RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. PubMed ID: 9582122

Distribution of ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system. PubMed ID: 11279364

The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. PubMed ID: 10779365

Cellular and subcellular localization of Ras guanyl nucleotide-releasing protein in the rat hippocampus. PubMed ID: 11738253

T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation. PubMed ID: 12626538

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes. PubMed ID: 15064353

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903