Por | ENSRNOG00000001442 | NCBI 29441

Details for: Por

Gene ID: 29441

Symbol: Por

Ensembl ID: ENSRNOG00000001442

Description: cytochrome p450 oxidoreductase

Associated with

Carnitine metabolic process
(GO:0009437)
Cellular organofluorine metabolic process
(GO:0090346)
Cellular response to follicle-stimulating hormone stimulus
(GO:0071372)
Cellular response to gonadotropin stimulus
(GO:0071371)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cytochrome-b5 reductase activity, acting on nad(p)h
(GO:0004128)
Cytosol
(GO:0005829)
Demethylation
(GO:0070988)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Fatty acid oxidation
(GO:0019395)
Flavin adenine dinucleotide binding
(GO:0050660)
Flavonoid metabolic process
(GO:0009812)
Fmn binding
(GO:0010181)
Hydrolase activity
(GO:0016787)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron-cytochrome-c reductase activity
(GO:0047726)
Nadp binding
(GO:0050661)
Nadph-hemoprotein reductase activity
(GO:0003958)
Negative regulation of apoptotic process
(GO:0043066)
Nitrate catabolic process
(GO:0043602)
Nitric oxide catabolic process
(GO:0046210)
Nitric oxide dioxygenase nad(p)h activity
(GO:0008941)
Oxidoreductase activity
(GO:0016491)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of steroid hormone biosynthetic process
(GO:0090031)
Regulation of cholesterol metabolic process
(GO:0090181)
Regulation of growth plate cartilage chondrocyte proliferation
(GO:0003420)
Response to dexamethasone
(GO:0071548)
Response to hormone
(GO:0009725)
Response to nutrient
(GO:0007584)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

NCPR_RAT

Genular Protein ID: 2619217577

Symbol: NCPR_RAT

Name: N/A

UniProtKB Accession Codes:

P00388

Database IDs:

Citations:

PubMed ID: 3919392

Title: Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains.

PubMed ID: 3919392

DOI: 10.1073/pnas.82.4.973

PubMed ID: 3082610

Title: Expression of rat NADPH-cytochrome P-450 reductase cDNA in Saccharomyces cerevisiae.

PubMed ID: 3082610

DOI: 10.1089/dna.1986.5.1

PubMed ID: 2125483

Title: NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein.

PubMed ID: 2125483

DOI: 10.1021/bi00494a009

PubMed ID: 9237990

Title: Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.

PubMed ID: 9237990

DOI: 10.1073/pnas.94.16.8411

PubMed ID: 11371558

Title: NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.

PubMed ID: 11371558

DOI: 10.1074/jbc.m101731200

PubMed ID: 19171935

Title: Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450.

PubMed ID: 19171935

DOI: 10.1074/jbc.m807868200

PubMed ID: 21345800

Title: Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding.

PubMed ID: 21345800

DOI: 10.1074/jbc.m111.230532

Sequence Information:

Length: 678
Mass: 76963
Checksum: AF3087E4D7A352D6
Sequence:

MGDSHEDTSA TMPEAVAEEV SLFSTTDMVL FSLIVGVLTY WFIFRKKKEE IPEFSKIQTT 
APPVKESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK DAHRYGMRGM SADPEEYDLA 
DLSSLPEIDK SLVVFCMATY GEGDPTDNAQ DFYDWLQETD VDLTGVKFAV FGLGNKTYEH 
FNAMGKYVDQ RLEQLGAQRI FELGLGDDDG NLEEDFITWR EQFWPAVCEF FGVEATGEES 
SIRQYELVVH EDMDVAKVYT GEMGRLKSYE NQKPPFDAKN PFLAAVTANR KLNQGTERHL 
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQIGEILGA DLDVIMSLNN LDEESNKKHP 
FPCPTTYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE HLHKMASSSG EGKELYLSWV 
VEARRHILAI LQDYPSLRPP IDHLCELLPR LQARYYSIAS SSKVHPNSVH ICAVAVEYEA 
KSGRVNKGVA TSWLRAKEPA GENGGRALVP MFVRKSQFRL PFKSTTPVIM VGPGTGIAPF 
MGFIQERAWL REQGKEVGET LLYYGCRRSD EDYLYREELA RFHKDGALTQ LNVAFSREQA 
HKVYVQHLLK RDREHLWKLI HEGGAHIYVC GDARNMAKDV QNTFYDIVAE FGPMEHTQAV 
DYVKKLMTKG RYSLDVWS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Por

Associated with

Other Information

Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains. PubMed ID: 3919392

Expression of rat NADPH-cytochrome P-450 reductase cDNA in Saccharomyces cerevisiae. PubMed ID: 3082610

NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein. PubMed ID: 2125483

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. PubMed ID: 9237990

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. PubMed ID: 11371558

Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. PubMed ID: 19171935

Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding. PubMed ID: 21345800