Details for: Gdf15

Gene ID: 29455

Symbol: Gdf15

Ensembl ID: ENSRNOG00000019661

Description: growth differentiation factor 15

Associated with

Other Information

Genular Protein ID: 4265449232

Symbol: GDF15_RAT

Name: N/A

UniProtKB Accession Codes:

Q9Z0J6

Database IDs:

AGR 1 AlphaFoldDB 1 CTD 1 EMBL 2 GO 23 Gene3D 1 GlyCosmos 1 GlyGen 1 InParanoid 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 eggNOG 1

Citations:

PubMed ID: 28953886

Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

PubMed ID: 28953886

DOI: 10.1038/nature24042

PubMed ID: 29144449

Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

PubMed ID: 29144449

DOI: 10.1038/nature24481

PubMed ID: 28846099

Title: GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

PubMed ID: 28846099

DOI: 10.1038/nm.4394

PubMed ID: 29046435

Title: Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

PubMed ID: 29046435

DOI: 10.1126/scitranslmed.aan8732

PubMed ID: 31928886

Title: GDF15 induces anorexia through nausea and emesis.

PubMed ID: 31928886

DOI: 10.1016/j.cmet.2019.12.004

PubMed ID: 34187898

Title: Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.

PubMed ID: 34187898

DOI: 10.1073/pnas.2106868118

PubMed ID: 37060902

Title: Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight.

PubMed ID: 37060902

DOI: 10.1016/j.cmet.2023.03.014

Sequence Information:

  • Length: 303
  • Mass: 33439
  • Checksum: FA828BE79C1052C9
  • Sequence:
    • MALRALHAQP TGGPQLRFLL FLLLLLLLLS WPSQGDALAL PEQRRSLSES QLNPDELRGR 
FQDLLSRLHA NQSREDSNSE PTPDPAVRIL SPEVRLGSHG RLLLRVNRAS LTQGLPEAYR 
VHRALLLLTP SSRPWDITRP LQRAISLQGP HARALRLRLA PPPDLAVLPS GGARLELHLR 
SAAGRGRRSA HLHPRDSCPL GPGRCCHLET VQATLEDLGW SDWVLSPRQL QLSMCVGECP 
HLYRSANTHA LIKARLHGLQ PDRVPAPCCV PSSYTPVVLM HRTDSGVSLQ TYDDLVAQGC 
HCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.