Details for: Vgf

Gene ID: 29461

Symbol: Vgf

Ensembl ID: ENSRNOG00000001416

Description: VGF nerve growth factor inducible

Associated with

Other Information

Genular Protein ID: 4143440852

Symbol: VGF_RAT

Name: Neurosecretory protein VGF

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2676516

Title: A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway.

PubMed ID: 2676516

DOI: 10.1002/j.1460-2075.1989.tb08345.x

PubMed ID: 2017159

Title: Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells.

PubMed ID: 2017159

DOI: 10.1128/mcb.11.5.2335-2349.1991

PubMed ID: 1377233

Title: NGF induces the expression of the VGF gene through a cAMP response element.

PubMed ID: 1377233

DOI: 10.1523/jneurosci.12-07-02573.1992

PubMed ID: 7595538

Title: Tissue-specific processing of the neuroendocrine protein VGF.

PubMed ID: 7595538

DOI: 10.1046/j.1471-4159.1995.65062441.x

PubMed ID: 12065665

Title: Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor.

PubMed ID: 12065665

DOI: 10.1046/j.1471-4159.2002.00842.x

PubMed ID: 16983076

Title: TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity.

PubMed ID: 16983076

DOI: 10.1073/pnas.0606102103

PubMed ID: 19164277

Title: Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.

PubMed ID: 19164277

DOI: 10.1074/mcp.m800501-mcp200

PubMed ID: 19466987

Title: In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat gastric motor functions.

PubMed ID: 19466987

DOI: 10.1111/j.1476-5381.2009.00192.x

PubMed ID: 19194657

Title: Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF.

PubMed ID: 19194657

DOI: 10.1007/s00018-009-8796-0

PubMed ID: 20551287

Title: Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus.

PubMed ID: 20551287

DOI: 10.1152/ajpendo.00768.2009

PubMed ID: 23940034

Title: Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.

PubMed ID: 23940034

DOI: 10.1074/jbc.m113.497214

PubMed ID: 24106277

Title: Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.

PubMed ID: 24106277

DOI: 10.1074/jbc.m113.510917

PubMed ID: 24704271

Title: Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus.

PubMed ID: 24704271

DOI: 10.1016/j.brainres.2014.03.038

PubMed ID: 25917832

Title: The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis.

PubMed ID: 25917832

DOI: 10.1530/jme-14-0313

PubMed ID: 28213131

Title: NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway.

PubMed ID: 28213131

DOI: 10.1016/j.bbrc.2017.02.064

PubMed ID: 28123945

Title: The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis.

PubMed ID: 28123945

DOI: 10.1016/j.molmet.2016.10.005

Sequence Information:

  • Length: 617
  • Mass: 68179
  • Checksum: 5E23E47DF460C7B4
  • Sequence:
  • MKTFTLPASV LFCFLLLIRG LGAAPPGRSD VYPPPLGSEH NGQVAEDAVS RPKDDSVPEV 
    RAARNSEPQD QGELFQGVDP RALAAVLLQA LDRPASPPAV PAGSQQGTPE EAAEALLTES 
    VRSQTHSLPA SEIQASAVAP PRPQTQDNDP EADDRSEELE ALASLLQELR DFSPSNAKRQ 
    QETAAAETET RTHTLTRVNL ESPGPERVWR ASWGEFQARV PERAPLPPSV PSQFQARMSE 
    NVPLPETHQF GEGVSSPKTH LGETLTPLSK AYQSLSAPFP KVRRLEGSFL GGSEAGERLL 
    QQGLAQVEAG RRQAEATRQA AAQEERLADL ASDLLLQYLL QGGARQRDLG GRGLQETQQE 
    RENEREEEAE QERRGGGEDE VGEEDEEAAE AEAEAEEAER ARQNALLFAE EEDGEAGAED 
    KRSQEEAPGH RRKDAEGTEE GGEEDDDDEE MDPQTIDSLI ELSTKLHLPA DDVVSIIEEV 
    EEKRKRKKNA PPEPVPPPRA APAPTHVRSP QPPPPAPARD ELPDWNEVLP PWDREEDEVF 
    PPGPYHPFPN YIRPRTLQPP ASSRRRHFHH ALPPARHHPD LEAQARRAQE EADAEERRLQ 
    EQEELENYIE HVLLHRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.