Ptgs2 | ENSRNOG00000002525 | NCBI 29527

Details for: Ptgs2

Gene ID: 29527

Symbol: Ptgs2

Ensembl ID: ENSRNOG00000002525

Description: prostaglandin-endoperoxide synthase 2

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Biosynthesis of dha-derived spms
(R-RNO-9018677)
Biosynthesis of dpa-derived spms
(R-RNO-9018683)
Biosynthesis of dpan-3 spms
(R-RNO-9025094)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-RNO-9027604)
Biosynthesis of epa-derived spms
(R-RNO-9018679)
Biosynthesis of specialized proresolving mediators (spms)
(R-RNO-9018678)
Fatty acid metabolism
(R-RNO-8978868)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of vitamins and cofactors
(R-RNO-196854)
Metabolism of water-soluble vitamins and cofactors
(R-RNO-196849)
Nicotinamide salvaging
(R-RNO-197264)
Nicotinate metabolism
(R-RNO-196807)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-RNO-2142770)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-RNO-2162123)
Angiogenesis
(GO:0001525)
Bone mineralization
(GO:0030282)
Brown fat cell differentiation
(GO:0050873)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to atp
(GO:0071318)
Cellular response to fluid shear stress
(GO:0071498)
Cellular response to heat
(GO:0034605)
Cellular response to homocysteine
(GO:1905375)
Cellular response to hypoxia
(GO:0071456)
Cellular response to lead ion
(GO:0071284)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to non-ionic osmotic stress
(GO:0071471)
Cellular response to organonitrogen compound
(GO:0071417)
Cyclooxygenase pathway
(GO:0019371)
Cytoplasm
(GO:0005737)
Decidualization
(GO:0046697)
Embryo implantation
(GO:0007566)
Enzyme binding
(GO:0019899)
Hair cycle
(GO:0042633)
Heme binding
(GO:0020037)
Learning
(GO:0007612)
Maintenance of blood-brain barrier
(GO:0035633)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:1902219)
Negative regulation of smooth muscle contraction
(GO:0045986)
Negative regulation of synaptic transmission, dopaminergic
(GO:0032227)
Nuclear inner membrane
(GO:0005637)
Nuclear outer membrane
(GO:0005640)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Peroxidase activity
(GO:0004601)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of brown fat cell differentiation
(GO:0090336)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of fibroblast growth factor production
(GO:0090271)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of platelet-derived growth factor production
(GO:0090362)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of transforming growth factor beta production
(GO:0071636)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Positive regulation of vasoconstriction
(GO:0045907)
Prostaglandin-endoperoxide synthase activity
(GO:0004666)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of blood pressure
(GO:0008217)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neuroinflammatory response
(GO:0150077)
Response to angiotensin
(GO:1990776)
Response to cytokine
(GO:0034097)
Response to estradiol
(GO:0032355)
Response to fatty acid
(GO:0070542)
Response to fructose
(GO:0009750)
Response to glucocorticoid
(GO:0051384)
Response to lipopolysaccharide
(GO:0032496)
Response to manganese ion
(GO:0010042)
Response to nematode
(GO:0009624)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to organonitrogen compound
(GO:0010243)
Response to oxidative stress
(GO:0006979)
Response to tumor necrosis factor
(GO:0034612)
Response to vitamin d
(GO:0033280)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Prostaglandin G/H synthase 2

Genular Protein ID: 4115566556

Symbol: PGH2_RAT

Name: Prostaglandin G/H synthase 2

UniProtKB Accession Codes:

P35355 Q64379 Q925V4

Database IDs:

Citations:

PubMed ID: 7916614

Title: Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA.

PubMed ID: 7916614

DOI: 10.1006/bbrc.1993.2506

PubMed ID: 8352945

Title: Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids.

PubMed ID: 8352945

DOI: 10.1016/0896-6273(93)90192-t

PubMed ID: 8203528

Title: Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells.

PubMed ID: 8203528

DOI: 10.1152/ajpgi.1994.266.5.g822

PubMed ID: 8274023

Title: Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression.

PubMed ID: 8274023

DOI: 10.1006/abbi.1993.1601

PubMed ID: 10816563

Title: Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling.

PubMed ID: 10816563

DOI: 10.1074/jbc.m001611200

PubMed ID: 1556140

Title: Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.

PubMed ID: 1556140

DOI: 10.1016/s0021-9258(18)42706-8

PubMed ID: 10966456

Title: Cyclooxygenases: structural, cellular, and molecular biology.

PubMed ID: 10966456

DOI: 10.1146/annurev.biochem.69.1.145

PubMed ID: 24605250

Title: Aspirin, cyclooxygenase inhibition and colorectal cancer.

PubMed ID: 24605250

DOI: 10.4292/wjgpt.v5.i1.40

Sequence Information:

Length: 604
Mass: 69164
Checksum: 98E418825D98FF0C
Sequence:

MLFRAVLLCA ALALSHAANP CCSNPCQNRG ECMSIGFDQY KCDCTRTGFY GENCTTPEFL 
TRIKLLLKPT PNTVHYILTH FKGVWNIVNN IPFLRNSIMR YVLTSRSHLI DSPPTYNVHY 
GYKSWEAFSN LSYYTRALPP VADDCPTPMG VKGNKELPDS KEVLEKVLLR REFIPDPQGT 
NMMFAFFAQH FTHQFFKTDQ KRGPGFTRGL GHGVDLNHVY GETLDRQHKL RLFQDGKLKY 
QVIGGEVYPP TVKDTQVDMI YPPHVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD 
ILKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNQQFQYQ 
NRIASEFNTL YHWHPLLPDT FNIEDQEYTF KQFLYNNSIL LEHGLAHFVE SFTRQIAGRV 
AGGRNVPIAV QAVAKASIDQ SREMKYQSLN EYRKRFSLKP YTSFEELTGE KEMAAELKAL 
YHDIDAMELY PALLVEKPRP DAIFGETMVE LGAPFSLKGL MGNPICSPQY WKPSTFGGEV 
GFRIINTASI QSLICNNVKG CPFASFNVQD PQPTKTATIN ASASHSRLDD INPTVLIKRR 
STEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptgs2

Associated with

Other Information

Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA. PubMed ID: 7916614

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. PubMed ID: 8352945

Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. PubMed ID: 8203528

Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. PubMed ID: 8274023

Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling. PubMed ID: 10816563

Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. PubMed ID: 1556140

Cyclooxygenases: structural, cellular, and molecular biology. PubMed ID: 10966456

Aspirin, cyclooxygenase inhibition and colorectal cancer. PubMed ID: 24605250