Aldh2 | ENSRNOG00000037815 | NCBI 29539

Details for: Aldh2

Gene ID: 29539

Symbol: Aldh2

Ensembl ID: ENSRNOG00000037815

Description: aldehyde dehydrogenase 2 family member

Associated with

Biological oxidations
(R-RNO-211859)
Ethanol oxidation
(R-RNO-71384)
Metabolism
(R-RNO-1430728)
Metabolism of proteins
(R-RNO-392499)
Metabolism of serotonin
(R-RNO-380612)
Mitochondrial protein degradation
(R-RNO-9837999)
Muscle contraction
(R-RNO-397014)
Neuronal system
(R-RNO-112316)
Neurotransmitter clearance
(R-RNO-112311)
Phase i - functionalization of compounds
(R-RNO-211945)
Serotonin clearance from the synaptic cleft
(R-RNO-380615)
Smooth muscle contraction
(R-RNO-445355)
Transmission across chemical synapses
(R-RNO-112315)
Acetaldehyde metabolic process
(GO:0006117)
Aldehyde catabolic process
(GO:0046185)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Apoptotic mitochondrial changes
(GO:0008637)
Behavioral response to ethanol
(GO:0048149)
Carboxylesterase activity
(GO:0106435)
Cellular detoxification of aldehyde
(GO:0110095)
Cellular response to fatty acid
(GO:0071398)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to resveratrol
(GO:1904639)
Ethanol catabolic process
(GO:0006068)
Ethanol metabolic process
(GO:0006067)
Flavin adenine dinucleotide binding
(GO:0050660)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Liver development
(GO:0001889)
Mitochondrial matrix
(GO:0005759)
Nadh binding
(GO:0070404)
Negative regulation of apoptotic process
(GO:0043066)
Nitroglycerin reductase activity
(GO:0018547)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
(GO:0016620)
Phenylacetaldehyde dehydrogenase activity
(GO:0008957)
Protein binding
(GO:0005515)
Regulation of dopamine biosynthetic process
(GO:1903179)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of response to oxidative stress
(GO:1902882)
Regulation of serotonin biosynthetic process
(GO:1905627)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to hyperoxia
(GO:0055093)
Response to ischemia
(GO:0002931)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Response to organic cyclic compound
(GO:0014070)
Response to progesterone
(GO:0032570)
Response to testosterone
(GO:0033574)

Other Information

Proteins

Aldehyde dehydrogenase, mitochondrial

Genular Protein ID: 135587124

Symbol: ALDH2_RAT

Name: Aldehyde dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P11884 Q6Q288 Q6Q289 Q6Q290 Q8K3V8 Q91ZD7

Database IDs:

Citations:

PubMed ID: 2540003

Title: Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences.

PubMed ID: 2540003

DOI: 10.1111/j.1432-1033.1989.tb14616.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3342060

Title: Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase.

PubMed ID: 3342060

DOI: 10.1016/0006-291x(88)90740-1

PubMed ID: 1898068

Title: Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli.

PubMed ID: 1898068

DOI: 10.1016/0003-9861(91)90464-t

PubMed ID: 12893989

Title: Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats.

PubMed ID: 12893989

DOI: 10.1097/01.fpc.0000054110.14659.62

PubMed ID: 1699808

Title: A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.

PubMed ID: 1699808

DOI: 10.1016/0014-5793(90)81088-6

PubMed ID: 10721992

Title: Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.

PubMed ID: 10721992

DOI: 10.1016/s0092-8674(00)80691-1

Sequence Information:

Length: 519
Mass: 56488
Checksum: 75C748202F1333E5
Sequence:

MLRAALSTAR RGPRLSRLLS AAATSAVPAP NQQPEVFCNQ IFINNEWHDA VSKKTFPTVN 
PSTGEVICQV AEGNKEDVDK AVKAAQAAFQ LGSPWRRMDA SDRGRLLYRL ADLIERDRTY 
LAALETLDNG KPYVISYLVD LDMVLKCLRY YAGWADKYHG KTIPIDGDFF SYTRHEPVGV 
CGQIIPWNFP LLMQAWKLGP ALATGNVVVM KVAEQTPLTA LYVANLIKEA GFPPGVVNIV 
PGFGPTAGAA IASHEDVDKV AFTGSTEVGH LIQVAAGSSN LKRVTLELGG KSPNIIMSDA 
DMDWAVEQAH FALFFNQGQC CCAGSRTFVQ EDVYDEFVER SVARAKSRVV GNPFDSRTEQ 
GPQVDETQFK KILGYIKSGQ QEGAKLLCGG GAAADRGYFI QPTVFGDVKD GMTIAKEEIF 
GPVMQILKFK TIEEVVGRAN NSKYGLAAAV FTKDLDKANY LSQALQAGTV WINCYDVFGA 
QSPFGGYKMS GSGRELGEYG LQAYTEVKTV TVKVPQKNS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aldh2

Associated with

Other Information

Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. PubMed ID: 2540003

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase. PubMed ID: 3342060

Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. PubMed ID: 1898068

Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats. PubMed ID: 12893989

A mitochondrial protein fraction catalyzing transport of the K+ analog T1+. PubMed ID: 1699808

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. PubMed ID: 10721992