Details for: Homer1

Gene ID: 29546

Symbol: Homer1

Ensembl ID: ENSRNOG00000047014

Description: homer scaffold protein 1

Associated with

Other Information

Genular Protein ID: 220493731

Symbol: HOME1_RAT

Name: VASP/Ena-related gene up-regulated during seizure and LTP 1

UniProtKB Accession Codes:

Q9Z214 O08567 O88800 Q9QUJ8 Q9QWN5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID 1 CDD 1 CTD 1 ELM 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9069287

Title: Homer: a protein that selectively binds metabotropic glutamate receptors.

PubMed ID: 9069287

DOI: 10.1038/386284a0

PubMed ID: 9257717

Title: Vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis.

PubMed ID: 9257717

DOI: 10.1016/s0014-5793(97)00775-8

PubMed ID: 9808458

Title: Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.

PubMed ID: 9808458

DOI: 10.1016/s0896-6273(00)80588-7

PubMed ID: 9824313

Title: Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain.

PubMed ID: 9824313

DOI: 10.1016/s0014-5793(98)01256-3

PubMed ID: 9727012

Title: Novel members of the Vesl/Homer family of PDZ-proteins that bind metabotropic glutamate receptors.

PubMed ID: 9727012

DOI: 10.1074/jbc.273.37.23969

PubMed ID: 11118290

Title: Evidence for the presence of two homer 1 transcripts in skeletal and cardiac muscles.

PubMed ID: 11118290

DOI: 10.1006/bbrc.2000.3948

PubMed ID: 9808459

Title: Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.

PubMed ID: 9808459

DOI: 10.1016/s0896-6273(00)80589-9

PubMed ID: 10433269

Title: Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.

PubMed ID: 10433269

DOI: 10.1016/s0896-6273(00)80810-7

PubMed ID: 12887973

Title: Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling.

PubMed ID: 12887973

DOI: 10.1016/s0143-4160(03)00112-x

PubMed ID: 12810060

Title: Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling.

PubMed ID: 12810060

DOI: 10.1016/s0143-4160(03)00082-4

PubMed ID: 10851183

Title: Homer: a link between neural activity and glutamate receptor function.

PubMed ID: 10851183

DOI: 10.1016/s0959-4388(00)00087-8

PubMed ID: 14528310

Title: PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.

PubMed ID: 14528310

DOI: 10.1038/nn1134

PubMed ID: 15034583

Title: The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.

PubMed ID: 15034583

DOI: 10.1038/nn1210

PubMed ID: 17584991

Title: A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.

PubMed ID: 17584991

DOI: 10.1124/mol.107.037796

PubMed ID: 30021165

Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.

PubMed ID: 30021165

DOI: 10.1016/j.celrep.2018.06.071

PubMed ID: 10798399

Title: Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.

PubMed ID: 10798399

DOI: 10.1016/s0896-6273(00)81145-9

PubMed ID: 12054806

Title: Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif.

PubMed ID: 12054806

DOI: 10.1016/s0022-2836(02)00170-5

PubMed ID: 19345194

Title: The postsynaptic density proteins Homer and Shank form a polymeric network structure.

PubMed ID: 19345194

DOI: 10.1016/j.cell.2009.01.050

Sequence Information:

  • Length: 366
  • Mass: 41305
  • Checksum: A6A21CB14207A384
  • Sequence:
    • MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST 
ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK 
MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPAQNA LPFSHSAGDR 
TQGLSHASSA ISKHWEAELA TLKGNNAKLT AALLESTANV KQWKQQLAAY QEEAERLHKR 
VTELECVSSQ ANAVHSHKTE LSQTVQELEE TLKVKEEEIE RLKQEIDNAR ELQEQRDSLT 
QKLQEVEIRN KDLEGQLSEL EQRLEKSQSE QDAFRSNLKT LLEILDGKIF ELTELRDNLA 
KLLECS

Genular Protein ID: 4121790819

Symbol: A6I4T3_RAT

Name: N/A

UniProtKB Accession Codes:

A6I4T3

Database IDs:

ARBA 5 CDD 1 CTD 1 EMBL 2 GO 4 Gene3D 2 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 RGD 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 354
  • Mass: 40124
  • Checksum: C8F4579BFE3E69BF
  • Sequence:
    • MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST 
ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK 
MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPAQNA LPFSHSSAIS 
KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN 
AVHSHKTELS QTVQELEETL KVKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD 
LEGQLSELEQ RLEKSQSEQD AFRSNLKTLL EILDGKIFEL TELRDNLAKL LECS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.