Details for: Map2k5

Gene ID: 29568

Symbol: Map2k5

Ensembl ID: ENSRNOG00000007926

Description: mitogen activated protein kinase kinase 5

Associated with

  • Atp binding
    (GO:0005524)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cytosol
    (GO:0005829)
  • Erk5 cascade
    (GO:0070375)
  • Heart development
    (GO:0007507)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Mapk cascade
    (GO:0000165)
  • Map kinase activity
    (GO:0004707)
  • Map kinase kinase activity
    (GO:0004708)
  • Membrane
    (GO:0016020)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000342)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of response to cytokine stimulus
    (GO:0060761)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein kinase activity
    (GO:0004672)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Signal transduction
    (GO:0007165)
  • Spindle
    (GO:0005819)

Other Information

Genular Protein ID: 3547518824

Symbol: MP2K5_RAT

Name: Dual specificity mitogen-activated protein kinase kinase 5

UniProtKB Accession Codes:

Q62862 Q62863 Q62864

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 Bgee 1 CDD 2 CTD 1 ChEBI 18 EC 4 EMBL 4 Ensembl 5 GO 30 Gene3D 1 GeneTree 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 3 Rhea 9 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7499418

Title: Isolation of MEK5 and differential expression of alternatively spliced forms.

PubMed ID: 7499418

DOI: 10.1074/jbc.270.48.28897

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20724525

Title: Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

PubMed ID: 20724525

DOI: 10.1096/fj.10-162636

Sequence Information:

  • Length: 448
  • Mass: 50198
  • Checksum: 1B1CC8B05789B90D
  • Sequence:
    • MLWLALGPFR AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTSGQVKLC 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
QFNDGNATVV SMWVCRALEE RRSQQGPP

Genular Protein ID: 2007947891

Symbol: A6J594_RAT

Name: N/A

UniProtKB Accession Codes:

A6J594

Database IDs:

ARBA 8 CDD 2 CTD 1 ChEBI 16 EC 3 EMBL 2 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RGD 2 RefSeq 1 Rhea 9 RuleBase 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 438
  • Mass: 49054
  • Checksum: E48EA719AAFB4A2D
  • Sequence:
    • MLWLALGPFR AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTSGQVKLC 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMEIQ KNQGSLMPLQ 
LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV QFNDGNATVV 
SMWVCRALEE RRSQQGPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.