Details for: Scn10a

Gene ID: 29571

Symbol: Scn10a

Ensembl ID: ENSRNOG00000032473

Description: sodium voltage-gated channel alpha subunit 10

Associated with

  • Av node cell action potential
    (GO:0086016)
  • Axon
    (GO:0030424)
  • Behavioral response to pain
    (GO:0048266)
  • Bundle of his cell action potential
    (GO:0086043)
  • C-fiber
    (GO:0044299)
  • Cardiac conduction
    (GO:0061337)
  • Circadian rhythm
    (GO:0007623)
  • Clathrin complex
    (GO:0071439)
  • Detection of mechanical stimulus involved in sensory perception
    (GO:0050974)
  • Detection of temperature stimulus involved in sensory perception of pain
    (GO:0050965)
  • Establishment of localization in cell
    (GO:0051649)
  • Glutamatergic synapse
    (GO:0098978)
  • Membrane depolarization during action potential
    (GO:0086010)
  • Membrane depolarization during cardiac muscle cell action potential
    (GO:0086012)
  • Neuronal action potential
    (GO:0019228)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Plasma membrane
    (GO:0005886)
  • Presynaptic membrane
    (GO:0042734)
  • Protein binding
    (GO:0005515)
  • Regulation of atrial cardiac muscle cell membrane depolarization
    (GO:0060371)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of monoatomic ion transmembrane transport
    (GO:0034765)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Sodium ion transmembrane transport
    (GO:0035725)
  • Sodium ion transport
    (GO:0006814)
  • Transmembrane transporter binding
    (GO:0044325)
  • Voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099508)
  • Voltage-gated sodium channel activity
    (GO:0005248)
  • Voltage-gated sodium channel activity involved in cardiac muscle cell action potential
    (GO:0086006)
  • Voltage-gated sodium channel complex
    (GO:0001518)

Other Information

Genular Protein ID: 1626129569

Symbol: SCNAA_RAT

Name: Sodium channel protein type 10 subunit alpha

UniProtKB Accession Codes:

Q62968 Q63554 Q6EWG6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 DrugCentral 1 ELM 1 EMBL 3 Ensembl 1 GO 28 Gene3D 4 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 RefSeq 1 Rhea 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8538791

Title: A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons.

PubMed ID: 8538791

DOI: 10.1038/379257a0

PubMed ID: 8626372

Title: Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

PubMed ID: 8626372

DOI: 10.1074/jbc.271.11.5953

PubMed ID: 15178439

Title: Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel.

PubMed ID: 15178439

DOI: 10.1016/j.bbrc.2004.05.026

PubMed ID: 15047701

Title: Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

PubMed ID: 15047701

DOI: 10.1074/jbc.m401281200

PubMed ID: 9450690

Title: Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia.

PubMed ID: 9450690

DOI: 10.1016/s0169-328x(97)00239-8

PubMed ID: 11487631

Title: Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons.

PubMed ID: 11487631

DOI: 10.1523/jneurosci.21-16-06077.2001

PubMed ID: 12050667

Title: Annexin II light chain regulates sensory neuron-specific sodium channel expression.

PubMed ID: 12050667

DOI: 10.1038/nature00781

PubMed ID: 12591166

Title: Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8.

PubMed ID: 12591166

DOI: 10.1016/s0169-328x(02)00661-7

PubMed ID: 12514212

Title: Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain.

PubMed ID: 12514212

DOI: 10.1523/jneurosci.23-01-00158.2003

Sequence Information:

  • Length: 1956
  • Mass: 219733
  • Checksum: 8FC58EDAD263AC67
  • Sequence:
    • MELPFASVGT TNFRRFTPES LAEIEKQIAA HRAAKKARTK HRGQEDKGEK PRPQLDLKAC 
NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKSRT ISRFSATWAL WLFSPFNLIR 
RTAIKVSVHS WFSIFITITI LVNCVCMTRT DLPEKVEYVF TVIYTFEALI KILARGFCLN 
EFTYLRDPWN WLDFSVITLA YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI 
HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCIRNG TDPHKADNLS SEMAEYIFIK 
PGTTDPLLCG NGSDAGHCPG GYVCLKTPDN PDFNYTSFDS FAWAFLSLFR LMTQDSWERL 
YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE EQSQATIAEI EAKEKKFQEA 
LEVLQKEQEV LAALGIDTTS LQSHSGSPLA SKNANERRPR VKSRVSEGST DDNRSPQSDP 
YNQRRMSFLG LSSGRRRASH GSVFHFRAPS QDISFPDGIT DDGVFHGDQE SRRGSILLGR 
GAGQTGPLPR SPLPQSPNPG RRHGEEGQLG VPTGELTAGA PEGPALDTTG QKSFLSAGYL 
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW RKFKMALFEL 
VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN IVFTVFFTME MAFKIIAFDP 
YYYFQKKWNI FDCVIVTVSL LELSASKKGS LSVLRTFRLL RVFKLAKSWP TLNTLIKIIG 
NSVGALGNLT FILAIIVFIF ALVGKQLLSE DYGCRKDGVS VWNGEKLRWH MCDFFHSFLV 
VFRILCGEWI ENMWVCMEVS QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP 
EDDGEVNNLQ LALARIQVLG HRASRAIASY ISSHCRFRWP KVETQLGMKP PLTSSEAKNH 
IATDAVSAAV GNLTKPALSS PKENHGDFIT DPNVWVSVPI AEGESDLDEL EEDMEQASQS 
SWQEEDPKGQ QEQLPQVQKC ENHQAARSPA SMMSSEDLAP YLGESWKRKD SPQVPAEGVD 
DTSSSEGSTV DCPDPEEILR KIPELADDLD EPDDCFTEGC TRRCPCCNVN TSKSPWATGW 
QVRKTCYRIV EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF 
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL RTLRALRPLR 
ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFSK CVDTRNNPFS 
NVNSTMVNNK SECHNQNSTG HFFWVNVKVN FDNVAMGYLA LLQVATFKGW MDIMYAAVDS 
GEINSQPNWE NNLYMYLYFV VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ 
KKYYNAMKKL GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDE 
QGEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL SIGSLLFSAI 
LKSLENYFSP TLFRVIRLAR IGRILRLIRA AKGIRTLLFA LMMSLPALFN IGLLLFLVMF 
IYSIFGMASF ANVVDEAGID DMFNFKTFGN SMLCLFQITT SAGWDGLLSP ILNTGPPYCD 
PNLPNSNGSR GNCGSPAVGI IFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED 
DFDMFYETWE KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH 
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRWK QEDLSATVIQ 
KAYRSYMLHR SLTLSNTLHV PRAEEDGVSL PGEGYVTFMA NSGLPDKSET ASATSFPPSY 
DSVTRGLSDR ANINPSSSMQ NEDEVAAKEG NSPGPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.