Ntrk3 | ENSRNOG00000018674 | NCBI 29613

Details for: Ntrk3

Gene ID: 29613

Symbol: Ntrk3

Ensembl ID: ENSRNOG00000018674

Description: neurotrophic receptor tyrosine kinase 3

Associated with

Activated ntrk3 signals through pi3k
(R-RNO-9603381)
Activated ntrk3 signals through plcg1
(R-RNO-9034793)
Neuronal system
(R-RNO-112316)
Ntf3 activates ntrk3 signaling
(R-RNO-9034013)
Protein-protein interactions at synapses
(R-RNO-6794362)
Receptor-type tyrosine-protein phosphatases
(R-RNO-388844)
Signaling by ntrk3 (trkc)
(R-RNO-9034015)
Signaling by ntrks
(R-RNO-166520)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axon extension involved in regeneration
(GO:0048677)
Cell differentiation
(GO:0030154)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to retinoic acid
(GO:0071300)
Circadian rhythm
(GO:0007623)
Cochlea development
(GO:0090102)
Cytoplasm
(GO:0005737)
Ephrin receptor signaling pathway
(GO:0048013)
Glutamatergic synapse
(GO:0098978)
Golgi membrane
(GO:0000139)
Gpi-linked ephrin receptor activity
(GO:0005004)
Heart development
(GO:0007507)
Intracellular membrane-bounded organelle
(GO:0043231)
Lens fiber cell differentiation
(GO:0070306)
Mechanoreceptor differentiation
(GO:0042490)
Multicellular organism development
(GO:0007275)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of protein phosphorylation
(GO:0001933)
Nervous system development
(GO:0007399)
Neuronal action potential propagation
(GO:0019227)
Neuron fate specification
(GO:0048665)
Neuron migration
(GO:0001764)
Neurotrophin binding
(GO:0043121)
Neurotrophin receptor activity
(GO:0005030)
Neurotrophin signaling pathway
(GO:0038179)
P53 binding
(GO:0002039)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of axon extension involved in regeneration
(GO:0048691)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of positive chemotaxis
(GO:0050927)
Positive regulation of synapse assembly
(GO:0051965)
Postsynaptic density assembly
(GO:0097107)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Regulation of presynapse assembly
(GO:1905606)
Response to axon injury
(GO:0048678)
Response to corticosterone
(GO:0051412)
Response to ethanol
(GO:0045471)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

NT-3 growth factor receptor
Q68G04_RAT

Genular Protein ID: 794476966

Symbol: NTRK3_RAT

Name: NT-3 growth factor receptor

UniProtKB Accession Codes:

Q03351

Database IDs:

Citations:

PubMed ID: 1488112

Title: Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system.

PubMed ID: 1488112

DOI: 10.1016/0306-4522(92)90292-a

PubMed ID: 8494647

Title: Alternative forms of rat TrkC with different functional capabilities.

PubMed ID: 8494647

DOI: 10.1016/0896-6273(93)90211-9

PubMed ID: 8494648

Title: The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.

PubMed ID: 8494648

DOI: 10.1016/0896-6273(93)90212-a

PubMed ID: 9856458

Title: Identification and characterization of novel substrates of Trk receptors in developing neurons.

PubMed ID: 9856458

DOI: 10.1016/s0896-6273(00)80620-0

PubMed ID: 12471037

Title: Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.

PubMed ID: 12471037

DOI: 10.1074/jbc.m208468200

PubMed ID: 15167895

Title: A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.

PubMed ID: 15167895

DOI: 10.1038/sj.emboj.7600253

PubMed ID: 17967490

Title: PTPsigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons.

PubMed ID: 17967490

DOI: 10.1016/j.bbamcr.2007.06.008

PubMed ID: 21775604

Title: JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

PubMed ID: 21775604

DOI: 10.1523/jneurosci.0436-11.2011

Sequence Information:

Length: 864
Mass: 97064
Checksum: A202E993E208F636
Sequence:

MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 
DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 
RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 
VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 
VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 
GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 
KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 
SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY REGPYQKGPF 
SVSWQQQRLA ASAASTLFNP SGNDFCIWCE VGGHTMLPIR WMPPESIMYR KFTTESDVWS 
FGVILWEIFT YGKQPWFQLS NTEVIECITQ GRVLERPRVC PKEVYDVMLG CWQREPQQRL 
NIKEIYKILH ALGKATPIYL DILG

Genular Protein ID: 1112756044

Symbol: Q68G04_RAT

Name: N/A

UniProtKB Accession Codes:

Q68G04

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 612
Mass: 68387
Checksum: 376F0F449792CE46
Sequence:

MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 
DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 
RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 
VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 
VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 
GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL 
NLKDNRDHLV PSTHYIYEEP EVQSGDVSYP RSHGFREIML NPISLSGHSK PLNHGIYVED 
VNVYFSKGRH GF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ntrk3

Associated with

Other Information

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. PubMed ID: 1488112

Alternative forms of rat TrkC with different functional capabilities. PubMed ID: 8494647

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. PubMed ID: 8494648

Identification and characterization of novel substrates of Trk receptors in developing neurons. PubMed ID: 9856458

Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling. PubMed ID: 12471037

A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. PubMed ID: 15167895

PTPsigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons. PubMed ID: 17967490

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. PubMed ID: 21775604

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334