Details for: Gria2
Associated with
Other Information
Genular Protein ID: 4207985022
Symbol: GRIA2_RAT
Name: AMPA-selective glutamate receptor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2166337
Title: A family of AMPA-selective glutamate receptors.
PubMed ID: 2166337
PubMed ID: 2168579
Title: Molecular cloning and functional expression of glutamate receptor subunit genes.
PubMed ID: 2168579
PubMed ID: 1699567
Title: A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties.
PubMed ID: 1699567
PubMed ID: 9351977
Title: N-glycosylation is not a prerequisite for glutamate receptor function but is essential for lectin modulation.
PubMed ID: 9351977
DOI: 10.1124/mol.52.5.861
PubMed ID: 1717158
Title: RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
PubMed ID: 1717158
PubMed ID: 9697855
Title: The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs.
PubMed ID: 9697855
PubMed ID: 10027300
Title: Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.
PubMed ID: 10027300
PubMed ID: 1699275
Title: Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
PubMed ID: 1699275
PubMed ID: 8848293
Title: Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696.
PubMed ID: 8848293
PubMed ID: 9069286
Title: GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
PubMed ID: 9069286
DOI: 10.1038/386279a0
PubMed ID: 10414981
Title: Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo.
PubMed ID: 10414981
PubMed ID: 12657670
Title: Ischemic insults derepress the gene silencer REST in neurons destined to die.
PubMed ID: 12657670
PubMed ID: 14687553
Title: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.
PubMed ID: 14687553
PubMed ID: 15240807
Title: Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases.
PubMed ID: 15240807
PubMed ID: 16037816
Title: Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2.
PubMed ID: 16037816
PubMed ID: 16793768
Title: Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics.
PubMed ID: 16793768
PubMed ID: 16630835
Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.
PubMed ID: 16630835
PubMed ID: 18817736
Title: AMPA receptor subunit-specific regulation by a distinct family of type II TARPs.
PubMed ID: 18817736
PubMed ID: 19234459
Title: Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
PubMed ID: 19234459
DOI: 10.1038/nn.2266
Title:
DOI: 10.1038/nn0609-808c
PubMed ID: 19265014
Title: Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.
PubMed ID: 19265014
PubMed ID: 20547133
Title: AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.
PubMed ID: 20547133
PubMed ID: 21172611
Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
PubMed ID: 21172611
PubMed ID: 21496646
Title: The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.
PubMed ID: 21496646
PubMed ID: 27756895
Title: MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.
PubMed ID: 27756895
DOI: 10.1038/srep35283
PubMed ID: 9804426
Title: Structure of a glutamate-receptor ligand-binding core in complex with kainate.
PubMed ID: 9804426
DOI: 10.1038/27692
PubMed ID: 11086992
Title: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
PubMed ID: 11086992
PubMed ID: 12501192
Title: Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.
PubMed ID: 12501192
DOI: 10.1021/bi020583k
PubMed ID: 12215417
Title: Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
PubMed ID: 12215417
PubMed ID: 12015593
PubMed ID: 12593667
Title: Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.
PubMed ID: 12593667
DOI: 10.1021/jm021020+
PubMed ID: 12872125
Title: Structural basis for partial agonist action at ionotropic glutamate receptors.
PubMed ID: 12872125
DOI: 10.1038/nn1091
PubMed ID: 12730367
Title: Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
PubMed ID: 12730367
PubMed ID: 16192394
Title: Mechanism of positive allosteric modulators acting on AMPA receptors.
PubMed ID: 16192394
PubMed ID: 15591246
Title: Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.
PubMed ID: 15591246
PubMed ID: 17018279
Title: Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
PubMed ID: 17018279
PubMed ID: 16483599
Title: The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
PubMed ID: 16483599
PubMed ID: 19946266
Title: X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
PubMed ID: 19946266
DOI: 10.1038/nature08624
PubMed ID: 21317873
Title: Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
PubMed ID: 21317873
PubMed ID: 21846932
Title: Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations.
PubMed ID: 21846932
PubMed ID: 25103405
Title: X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.
PubMed ID: 25103405
Sequence Information:
- Length: 883
- Mass: 98688
- Checksum: DEFA817027C1CCD1
- Sequence:
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE TYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT ATIKYTSALT YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLGNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK NPQNINPSSS QNSQNFATYK EGYNVYGIES VKI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.