P2rx4 | ENSRNOG00000001300 | NCBI 29659

Details for: P2rx4

Gene ID: 29659

Symbol: P2rx4

Ensembl ID: ENSRNOG00000001300

Description: purinergic receptor P2X 4

Associated with

Elevation of cytosolic ca2+ levels
(R-RNO-139853)
Hemostasis
(R-RNO-109582)
Platelet calcium homeostasis
(R-RNO-418360)
Platelet homeostasis
(R-RNO-418346)
Apical part of cell
(GO:0045177)
Apoptotic signaling pathway
(GO:0097190)
Atp-gated ion channel activity
(GO:0035381)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Behavioral response to pain
(GO:0048266)
Cadherin binding
(GO:0045296)
Calcium-mediated signaling
(GO:0019722)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Cell body
(GO:0044297)
Cell junction
(GO:0030054)
Cellular response to atp
(GO:0071318)
Cellular response to zinc ion
(GO:0071294)
Copper ion binding
(GO:0005507)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Excitatory postsynaptic potential
(GO:0060079)
Extracellularly atp-gated monoatomic cation channel activity
(GO:0004931)
Identical protein binding
(GO:0042802)
Inorganic cation transmembrane transport
(GO:0098662)
Ligand-gated calcium channel activity
(GO:0099604)
Ligand-gated monoatomic cation channel activity
(GO:0099094)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Monoatomic cation transmembrane transport
(GO:0098655)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Neuronal action potential
(GO:0019228)
Neuronal cell body
(GO:0043025)
Nitric oxide biosynthetic process
(GO:0006809)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of endothelial cell chemotaxis
(GO:2001028)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Purinergic nucleotide receptor activity
(GO:0001614)
Purinergic nucleotide receptor signaling pathway
(GO:0035590)
Regulation of blood pressure
(GO:0008217)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of chemotaxis
(GO:0050920)
Regulation of ruffle assembly
(GO:1900027)
Regulation of sodium ion transport
(GO:0002028)
Relaxation of cardiac muscle
(GO:0055119)
Response to atp
(GO:0033198)
Response to axon injury
(GO:0048678)
Response to fluid shear stress
(GO:0034405)
Response to ischemia
(GO:0002931)
Sensory perception of pain
(GO:0019233)
Sensory perception of touch
(GO:0050975)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Terminal bouton
(GO:0043195)
Vasodilation
(GO:0042311)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

P2X purinoceptor 4

Genular Protein ID: 391269686

Symbol: P2RX4_RAT

Name: P2X purinoceptor 4

UniProtKB Accession Codes:

P51577

Database IDs:

Citations:

PubMed ID: 8551329

Title: A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain.

PubMed ID: 8551329

DOI: 10.1523/jneurosci.16-02-00448.1996

PubMed ID: 7498461

Title: A P2X purinoceptor cDNA conferring a novel pharmacological profile.

PubMed ID: 7498461

DOI: 10.1016/0014-5793(95)01203-q

PubMed ID: 8602843

Title: Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues.

PubMed ID: 8602843

DOI: 10.1006/bbrc.1996.0380

PubMed ID: 8598206

Title: An antagonist-insensitive P2X receptor expressed in epithelia and brain.

PubMed ID: 8598206

DOI: 10.1002/j.1460-2075.1996.tb00333.x

PubMed ID: 8622997

Title: P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

PubMed ID: 8622997

DOI: 10.1073/pnas.93.8.3684

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12917686

Title: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.

PubMed ID: 12917686

DOI: 10.1038/nature01786

PubMed ID: 15985462

Title: Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors.

PubMed ID: 15985462

DOI: 10.1242/jcs.02451

PubMed ID: 24762105

Title: Involvement of ectodomain Leu 214 in ATP binding and channel desensitization of the P2X4 receptor.

PubMed ID: 24762105

DOI: 10.1021/bi401711n

PubMed ID: 24817123

Title: P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.

PubMed ID: 24817123

DOI: 10.1074/jbc.m114.552158

PubMed ID: 25662851

Title: Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding.

PubMed ID: 25662851

DOI: 10.1016/j.febslet.2015.01.034

Sequence Information:

Length: 388
Mass: 43501
Checksum: C7B0FC9A94EF8D9A
Sequence:

MAGCCSVLGS FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW EKGYQETDSV 
VSSVTTKAKG VAVTNTSQLG FRIWDVADYV IPAQEENSLF IMTNMIVTVN QTQSTCPEIP 
DKTSICNSDA DCTPGSVDTH SSGVATGRCV PFNESVKTCE VAAWCPVEND VGVPTPAFLK 
AAENFTLLVK NNIWYPKFNF SKRNILPNIT TSYLKSCIYN AQTDPFCPIF RLGTIVEDAG 
HSFQEMAVEG GIMGIQIKWD CNLDRAASLC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY 
RDLAGKEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT VLCDVIVLYC 
MKKKYYYRDK KYKYVEDYEQ GLSGEMNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: P2rx4

Associated with

Other Information

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. PubMed ID: 8551329

A P2X purinoceptor cDNA conferring a novel pharmacological profile. PubMed ID: 7498461

Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. PubMed ID: 8602843

An antagonist-insensitive P2X receptor expressed in epithelia and brain. PubMed ID: 8598206

P2X4: an ATP-activated ionotropic receptor cloned from rat brain. PubMed ID: 8622997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. PubMed ID: 12917686

Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. PubMed ID: 15985462

Involvement of ectodomain Leu 214 in ATP binding and channel desensitization of the P2X4 receptor. PubMed ID: 24762105

P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. PubMed ID: 24817123

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. PubMed ID: 25662851