Details for: Scn1b

Gene ID: 29686

Symbol: Scn1b

Ensembl ID: ENSRNOG00000021102

Description: sodium voltage-gated channel beta subunit 1

Associated with

  • Axon guidance
    (GO:0007411)
  • Cardiac conduction
    (GO:0061337)
  • Cardiac muscle cell action potential involved in contraction
    (GO:0086002)
  • Cardiac muscle contraction
    (GO:0060048)
  • Corticospinal neuron axon guidance
    (GO:0021966)
  • Intercalated disc
    (GO:0014704)
  • Locomotion
    (GO:0040011)
  • Membrane depolarization
    (GO:0051899)
  • Membrane depolarization during cardiac muscle cell action potential
    (GO:0086012)
  • Membrane depolarization during purkinje myocyte cell action potential
    (GO:0086047)
  • Neuronal action potential propagation
    (GO:0019227)
  • Neuron projection development
    (GO:0031175)
  • Node of ranvier
    (GO:0033268)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of sodium ion transport
    (GO:0010765)
  • Protein binding
    (GO:0005515)
  • Regulation of atrial cardiac muscle cell membrane depolarization
    (GO:0060371)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of sodium ion transmembrane transporter activity
    (GO:2000649)
  • Regulation of sodium ion transport
    (GO:0002028)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Response to pyrethroid
    (GO:0046684)
  • Sodium channel complex
    (GO:0034706)
  • Sodium channel inhibitor activity
    (GO:0019871)
  • Sodium channel regulator activity
    (GO:0017080)
  • Sodium ion transmembrane transport
    (GO:0035725)
  • T-tubule
    (GO:0030315)
  • Transmembrane transporter binding
    (GO:0044325)
  • Voltage-gated sodium channel activity
    (GO:0005248)
  • Voltage-gated sodium channel activity involved in cardiac muscle cell action potential
    (GO:0086006)
  • Voltage-gated sodium channel activity involved in purkinje myocyte action potential
    (GO:0086062)
  • Voltage-gated sodium channel complex
    (GO:0001518)

Other Information

Genular Protein ID: 3737008194

Symbol: SCN1B_RAT

Name: Sodium channel subunit beta-1

UniProtKB Accession Codes:

Q00954 Q505J0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 CORUM 1 CTD 1 ChEMBL 1 EMBL 2 Ensembl 4 ExpressionAtlas 1 GO 34 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1375395

Title: Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.

PubMed ID: 1375395

DOI: 10.1126/science.1375395

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8282123

Title: Modulation of the skeletal muscle sodium channel alpha-subunit by the beta 1-subunit.

PubMed ID: 8282123

DOI: 10.1016/0014-5793(93)80871-q

PubMed ID: 8021275

Title: The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits.

PubMed ID: 8021275

DOI: 10.1016/s0021-9258(17)32490-0

PubMed ID: 11470829

Title: Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain.

PubMed ID: 11470829

DOI: 10.1083/jcb.200102086

PubMed ID: 15178439

Title: Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel.

PubMed ID: 15178439

DOI: 10.1016/j.bbrc.2004.05.026

PubMed ID: 22425777

Title: Identification of an intra-molecular disulfide bond in the sodium channel beta1-subunit.

PubMed ID: 22425777

DOI: 10.1016/j.bbrc.2012.02.163

PubMed ID: 28012039

Title: Characterization of specific allosteric effects of the Na+ channel beta1 subunit on the Nav1.4 isoform.

PubMed ID: 28012039

DOI: 10.1007/s00249-016-1193-3

Sequence Information:

  • Length: 218
  • Mass: 24692
  • Checksum: 0BA84FC44FF2306B
  • Sequence:
    • MGTLLALVVG AVLVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT AETFTEWTFR 
QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYE 
CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMVY 
CYKKIAAATE AAAQENASEY LAITSESKEN CTGVQVAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.