Details for: Eif2ak3

Gene ID: 29702

Symbol: Eif2ak3

Ensembl ID: ENSRNOG00000006069

Description: eukaryotic translation initiation factor 2 alpha kinase 3

Associated with

  • Cellular responses to stimuli
    (R-RNO-8953897)
  • Cellular responses to stress
    (R-RNO-2262752)
  • Perk regulates gene expression
    (R-RNO-381042)
  • Unfolded protein response (upr)
    (R-RNO-381119)
  • Angiogenesis
    (GO:0001525)
  • Atp binding
    (GO:0005524)
  • Bone mineralization
    (GO:0030282)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to cold
    (GO:0070417)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Chondrocyte development
    (GO:0002063)
  • Cytoplasm
    (GO:0005737)
  • Eif2alpha phosphorylation in response to endoplasmic reticulum stress
    (GO:0036492)
  • Endocrine pancreas development
    (GO:0031018)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum organization
    (GO:0007029)
  • Endoplasmic reticulum quality control compartment
    (GO:0044322)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Enzyme binding
    (GO:0019899)
  • Er overload response
    (GO:0006983)
  • Eukaryotic translation initiation factor 2alpha kinase activity
    (GO:0004694)
  • Fat cell differentiation
    (GO:0045444)
  • Hsp90 protein binding
    (GO:0051879)
  • Identical protein binding
    (GO:0042802)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Lactation
    (GO:0007595)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of myelination
    (GO:0031642)
  • Negative regulation of translation
    (GO:0017148)
  • Negative regulation of translation in response to endoplasmic reticulum stress
    (GO:1902010)
  • Negative regulation of translation in response to stress
    (GO:0032055)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Pancreas development
    (GO:0031016)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glutathione biosynthetic process
    (GO:1903788)
  • Positive regulation of protein localization to nucleus
    (GO:1900182)
  • Positive regulation of signal transduction
    (GO:0009967)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Protein kinase activity
    (GO:0004672)
  • Protein phosphatase binding
    (GO:0019903)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation
    (GO:0060734)
  • Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902235)
  • Regulation of fatty acid metabolic process
    (GO:0019217)
  • Regulation of translational initiation
    (GO:0006446)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to manganese-induced endoplasmic reticulum stress
    (GO:1990737)
  • Skeletal system development
    (GO:0001501)
  • Srebp signaling pathway
    (GO:0032933)
  • Translation
    (GO:0006412)

Other Information

Genular Protein ID: 30826319

Symbol: E2AK3_RAT

Name: Eukaryotic translation initiation factor 2-alpha kinase 3

UniProtKB Accession Codes:

Q9Z1Z1

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 2 CTD 1 ChEBI 12 ChEMBL 1 EC 3 EMBL 1 Ensembl 4 GO 58 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 1 Rhea 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9819435

Title: Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.

PubMed ID: 9819435

DOI: 10.1128/mcb.18.12.7499

PubMed ID: 10026192

Title: Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.

PubMed ID: 10026192

DOI: 10.1074/jbc.274.9.5723

PubMed ID: 10854322

Title: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.

PubMed ID: 10854322

DOI: 10.1038/35014014

Sequence Information:

  • Length: 1108
  • Mass: 124770
  • Checksum: B3716B1FD26ED32B
  • Sequence:
    • MERATQPRPR ALLLLFLLLG CAAGISAVAR ARSLLAPTSD TAFGLGAAAA PTSAARVPAV 
ATAEVTVEDA EALPAASGEQ ESRATESDDD VELRPRGRSL VIISTLDGRI AALDAENHGK 
KQWDLDVGSG SLVSSSLSKP EVFGNKMIIP SLDGDLFQWD RDRESMEAVP FTVESLLESS 
YKFGDDVVLV GGKSLTTYGL SAYSGKLRYI CSALGCRRWD SDEMEEEEDI LLLQRTQKTV 
RAVGPRSGSE KWNFSVGHFE LRYIPDMETR AGFIESTFKL GGNKEDSKII SDVEEQDVDT 
VIKVSVADWK VMAFSKKGGR LEWEYQFCTP IASAWLVRDG KVIPISLFDD TSYTANEEVL 
EDEEDIVEAA RGATENSVYL GMYRGQLYLQ SSVRVSEKFP TRPKALESVN GESAIIPLPT 
IKWKPLIHSP SRTPVLVGSD EFDKCLSNDK YSHEEYSNGA LSILQYPYDN GYYLPYYKRE 
RNKRSTQITV RFLDSPHYSK NIRKKDPILL LHWWKEIFGT ILLCIVATTF IVRRLFHPQP 
HRQRKESETQ CQTESKYDSV SADNSDNSWN DIKHSGYVSR YLTDFEPIQC MGRGGFGVVF 
EAKNKVDDCN YAIKRIRLPN RELAREKVMR EVKALAKLEH PGIVRYFNAW LETPPEKWQE 
EMDEIWLKDE STDWPLSSPS PMDAPSVKIR QMDPFSTKEQ IEVIAPSPER SRSFSVGISC 
GRTSSSESQF SPLEFSGTDC GDNSDSEDAA HNLQDSCLTD CDMEDGTVDG DDEGHSFELC 
PSEASPYTRS REGTSSSIVF EDSGCDNASS KEDPRMNRLH NGHHYVNKLT EFKHSSSRSS 
SEATLSTSPT RPTTLSLDFT RNTVDRLQPS SPKVYLYIQM QLCRKENLKD WMNRRCSMED 
REHRVCLHIF LQIAEAVQFL HSKGLMHRDL KPSNIFFTMD DVVKVGDFGL VTAMDQDEEE 
QTVLTPMPAY ATHTGQVGTK LYMSPEQIHG NNYSHKVDIF SLGLILFELL YPFSTQMERV 
RTLTDVRNLK FPPLFTQKYP QEHMMVQDML SPSPMERPEA TDIIENAVFE NLEFPGKTVL 
RQRSRSLSSS GTKHSRQPSS TFSPLPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.