Details for: ACAA1

Gene ID: 30

Symbol: ACAA1

Ensembl ID: ENSG00000060971

Description: acetyl-CoA acyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.4
    Marker Score: 8527
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.37
    Marker Score: 11363
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.05
    Marker Score: 3163
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.04
    Marker Score: 6418
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.02
    Marker Score: 2970
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.92
    Marker Score: 6303
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.81
    Marker Score: 15637
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.77
    Marker Score: 9509
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.7
    Marker Score: 2057.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.64
    Marker Score: 1704
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.62
    Marker Score: 10397
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.61
    Marker Score: 2819.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.6
    Marker Score: 3113
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.57
    Marker Score: 6785
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.57
    Marker Score: 6161
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.55
    Marker Score: 3663
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.55
    Marker Score: 3538
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.51
    Marker Score: 15335
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.51
    Marker Score: 6161
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.49
    Marker Score: 3722
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.41
    Marker Score: 3780
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.36
    Marker Score: 1929.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.35
    Marker Score: 5192
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.34
    Marker Score: 8544
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.33
    Marker Score: 8487
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.32
    Marker Score: 1348
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.31
    Marker Score: 33526
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.29
    Marker Score: 2051
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.28
    Marker Score: 2272
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.28
    Marker Score: 1288
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.28
    Marker Score: 3221
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.27
    Marker Score: 1369
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.26
    Marker Score: 43737
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.26
    Marker Score: 1256
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.26
    Marker Score: 841
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.25
    Marker Score: 70110
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.25
    Marker Score: 726
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.24
    Marker Score: 357
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.22
    Marker Score: 2130
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.22
    Marker Score: 815
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1235
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9503
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.21
    Marker Score: 1309.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.21
    Marker Score: 505
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.2
    Marker Score: 1006
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.18
    Marker Score: 862
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.18
    Marker Score: 815
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.18
    Marker Score: 293
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.17
    Marker Score: 2816
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.16
    Marker Score: 402
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.16
    Marker Score: 1922
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.15
    Marker Score: 1223
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.15
    Marker Score: 561
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.14
    Marker Score: 2717
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1215
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.14
    Marker Score: 466
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.13
    Marker Score: 426
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.13
    Marker Score: 459
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 264
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.12
    Marker Score: 4160
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 524
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.11
    Marker Score: 265
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 757
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1
    Marker Score: 12401
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.1
    Marker Score: 8162
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.1
    Marker Score: 410
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.09
    Marker Score: 1094.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.09
    Marker Score: 601
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 690
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.09
    Marker Score: 856
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.08
    Marker Score: 1295
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.08
    Marker Score: 311
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.08
    Marker Score: 593
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.07
    Marker Score: 1288
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.07
    Marker Score: 1714
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.06
    Marker Score: 1116
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.06
    Marker Score: 1634
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.06
    Marker Score: 527
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.06
    Marker Score: 2399
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.06
    Marker Score: 299
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.04
    Marker Score: 2691
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.04
    Marker Score: 512
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.04
    Marker Score: 10428.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.03
    Marker Score: 1849
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.02
    Marker Score: 1172
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.02
    Marker Score: 1679
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.02
    Marker Score: 6669
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.02
    Marker Score: 1857
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.02
    Marker Score: 524
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.02
    Marker Score: 10499
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.02
    Marker Score: 258
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.02
    Marker Score: 2807
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.01
    Marker Score: 1345
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.01
    Marker Score: 290
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.01
    Marker Score: 352
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1
    Marker Score: 1063
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1
    Marker Score: 726
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1
    Marker Score: 263
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1
    Marker Score: 663

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Other Information

**Key characteristics**: * ACAA1 gene is located on chromosome 19p13.2. * It is a multi-exon gene, with four exons and three introns. * The protein encoded by ACAA1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * ACAA1 is expressed in a variety of cell types, including epithelial cells, hepatocytes, and immune cells. **Pathways and functions**: * ACAA1 is involved in multiple metabolic pathways, including acetate and acetyl-CoA metabolism, fatty acid metabolism, and the immune response. * It is a key enzyme in the synthesis of palmitoyl-CoA and other fatty acid derivatives. * ACAA1 is also involved in the regulation of peroxisomal protein import and fatty acid oxidation. * It plays an important role in the clearance of oxidized phospholipids and in the regulation of inflammation. **Clinical significance**: * Mutations in the ACAA1 gene have been linked to several human diseases, including atherosclerosis, heart disease, and cancer. * Studies of ACAA1 function have implications for understanding the pathogenesis of these diseases. * Targeting ACAA1 has been explored as a potential therapeutic strategy for these disorders. **Additional information**: * ACAA1 is a highly conserved protein, with a similar gene found in other organisms. * It is a substrate for the enzyme ACAC1, which is involved in the metabolism of ketone bodies. * ACAA1 is a regulator of the immune response, and its expression is influenced by cytokines and growth factors.

Genular Protein ID: 327702612

Symbol: THIK_HUMAN

Name: Acetyl-CoA C-myristoyltransferase

UniProtKB Accession Codes:

P09110 G5E935 Q96CA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 CarbonylDB 1 ChEBI 23 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3194209

Title: Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase.

PubMed ID: 3194209

DOI: 10.1093/nar/16.21.10369

PubMed ID: 2726492

Title: Complete cDNA sequence of human foetal liver peroxisomal 3-oxoacyl-CoA thiolase.

PubMed ID: 2726492

DOI: 10.1093/nar/17.9.3588

PubMed ID: 1679347

Title: Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient.

PubMed ID: 1679347

DOI: 10.1016/0167-4781(91)90035-k

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2882519

Title: Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency.

PubMed ID: 2882519

DOI: 10.1073/pnas.84.8.2494

PubMed ID: 11734571

Title: Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.

PubMed ID: 11734571

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22057399

Title: Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.

PubMed ID: 22057399

DOI: 10.1074/jbc.m111.301853

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25538232

Title: Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.

PubMed ID: 25538232

DOI: 10.1074/jbc.m114.601575

Sequence Information:

  • Length: 424
  • Mass: 44292
  • Checksum: 71B2BBAFA06AE412
  • Sequence:
    • MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT 
PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN 
RQCSSGLQAV ASIAGGIRNG SYDIGMACGV ESMSLADRGN PGNITSRLME KEKARDCLIP 
MGITSENVAE RFGISREKQD TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI 
TVTQDEGIRP STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI 
LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS QAAYCVEKLR 
LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR AYGVVSMCIG TGMGAAAVFE 
YPGN

Genular Protein ID: 2951958359

Symbol: A0A140VJX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJX0

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 23 DNASU 1 EC 3 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 4 RefSeq 1 Rhea 12 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 331
  • Mass: 34665
  • Checksum: 8137A0AC448FBA24
  • Sequence:
    • MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT 
PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN 
RQCSSGLQAV ASIAGGIRNG SYDIGMACGI TSENVAERFG ISREKQDTFA LASQQKAARA 
QSKGCFQAEI VPVTTTVHDD KGTKRSITVT QDEGIRPSTT MEGLAKLKPA FKKDGSTTAG 
LTVSDVDIFE INEAFASQAA YCVEKLRLPP EKVNPLGGAV ALGHPLGCTG ARQVITLLNE 
LKRRGKRAYG VVSMCIGTGM GAAAVFEYPG N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.