Details for: ACAA1

Gene ID: 30

Symbol: ACAA1

Ensembl ID: ENSG00000060971

Description: acetyl-CoA acyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 240.3481
    Cell Significance Index: -37.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.7094
    Cell Significance Index: -35.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.0385
    Cell Significance Index: -35.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.4121
    Cell Significance Index: -40.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.7238
    Cell Significance Index: -39.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.2290
    Cell Significance Index: -40.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.2352
    Cell Significance Index: -35.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.0429
    Cell Significance Index: -39.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7293
    Cell Significance Index: -34.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2634
    Cell Significance Index: -40.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5171
    Cell Significance Index: -26.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2203
    Cell Significance Index: -11.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.1298
    Cell Significance Index: 38.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7044
    Cell Significance Index: 140.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4152
    Cell Significance Index: 435.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1230
    Cell Significance Index: 261.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9839
    Cell Significance Index: 119.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7940
    Cell Significance Index: 195.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6148
    Cell Significance Index: 75.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2726
    Cell Significance Index: 82.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2680
    Cell Significance Index: 251.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1892
    Cell Significance Index: 16.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9961
    Cell Significance Index: 45.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9557
    Cell Significance Index: 67.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9173
    Cell Significance Index: 125.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8351
    Cell Significance Index: 62.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7964
    Cell Significance Index: 23.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7886
    Cell Significance Index: 430.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6366
    Cell Significance Index: 44.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5652
    Cell Significance Index: 113.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5366
    Cell Significance Index: 8.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5007
    Cell Significance Index: 221.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4552
    Cell Significance Index: 58.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4480
    Cell Significance Index: 12.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4295
    Cell Significance Index: 20.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4153
    Cell Significance Index: 79.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4104
    Cell Significance Index: 48.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3606
    Cell Significance Index: 325.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3517
    Cell Significance Index: 60.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3420
    Cell Significance Index: 44.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2412
    Cell Significance Index: 6.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2290
    Cell Significance Index: 82.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2090
    Cell Significance Index: 5.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2086
    Cell Significance Index: 3.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1933
    Cell Significance Index: 19.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1592
    Cell Significance Index: 25.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1151
    Cell Significance Index: 4.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1059
    Cell Significance Index: 73.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0667
    Cell Significance Index: 7.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0596
    Cell Significance Index: 1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0422
    Cell Significance Index: 30.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0259
    Cell Significance Index: 1.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0085
    Cell Significance Index: 6.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0138
    Cell Significance Index: -25.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0169
    Cell Significance Index: -26.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0224
    Cell Significance Index: -30.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0250
    Cell Significance Index: -0.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0262
    Cell Significance Index: -16.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0284
    Cell Significance Index: -17.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0487
    Cell Significance Index: -0.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0508
    Cell Significance Index: -28.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0596
    Cell Significance Index: -27.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0624
    Cell Significance Index: -1.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0781
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0782
    Cell Significance Index: -8.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0880
    Cell Significance Index: -4.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0888
    Cell Significance Index: -7.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0973
    Cell Significance Index: -20.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1061
    Cell Significance Index: -30.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1137
    Cell Significance Index: -2.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1170
    Cell Significance Index: -17.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1527
    Cell Significance Index: -2.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1742
    Cell Significance Index: -4.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1915
    Cell Significance Index: -9.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2178
    Cell Significance Index: -5.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2270
    Cell Significance Index: -26.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2450
    Cell Significance Index: -5.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2709
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3009
    Cell Significance Index: -20.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3307
    Cell Significance Index: -2.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3410
    Cell Significance Index: -11.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3722
    Cell Significance Index: -10.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3760
    Cell Significance Index: -39.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3994
    Cell Significance Index: -25.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4045
    Cell Significance Index: -5.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4441
    Cell Significance Index: -24.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4704
    Cell Significance Index: -28.8400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.4869
    Cell Significance Index: -0.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4968
    Cell Significance Index: -7.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4988
    Cell Significance Index: -4.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5167
    Cell Significance Index: -5.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5342
    Cell Significance Index: -23.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5462
    Cell Significance Index: -17.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5765
    Cell Significance Index: -9.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6284
    Cell Significance Index: -18.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6401
    Cell Significance Index: -24.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7061
    Cell Significance Index: -20.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACAA1 is a cytosolic enzyme that belongs to the acyl-CoA acyltransferase family. It exhibits a high degree of specificity for transferring an acyl group from acetyl-CoA to a lysine residue in proteins, resulting in the formation of a fatty acylated protein. ACAA1 is characterized by its ability to catalyze various acyl-CoA transfer reactions, including the transfer of palmitoyl-CoA, myristoyl-CoA, and stearoyl-CoA to target proteins. The enzyme is also involved in the regulation of protein function, cell signaling, and immune responses. **Pathways and Functions** ACAA1 is involved in several metabolic pathways, including: 1. **Fatty Acid Metabolism**: ACAA1 plays a crucial role in the regulation of fatty acid metabolism by catalyzing the transfer of acyl-CoA groups to proteins, resulting in the formation of fatty acylated proteins. 2. **Immune Response**: ACAA1 is involved in the regulation of immune responses by modulating the function of immune cells, such as neutrophils and macrophages. 3. **Lipid Synthesis**: ACAA1 is involved in the synthesis of lipids, including triglycerides and cholesterol esters. 4. **Protein Modification**: ACAA1 is involved in the modification of proteins by transferring acyl-CoA groups, resulting in the formation of fatty acylated proteins. 5. **Cell Signaling**: ACAA1 is involved in the regulation of cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. **Clinical Significance** Dysregulation of ACAA1 has been implicated in various diseases, including: 1. **Metabolic Disorders**: ACAA1 deficiency has been associated with metabolic disorders, such as obesity and insulin resistance. 2. **Cancer**: ACAA1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Autoimmune Diseases**: ACAA1 is involved in the regulation of immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological Disorders**: ACAA1 is involved in the regulation of neuronal function and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ACAA1 is a crucial enzyme involved in various metabolic pathways, including fatty acid metabolism, immune response, and lipid synthesis. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of ACAA1 in human health and disease.

Genular Protein ID: 327702612

Symbol: THIK_HUMAN

Name: Acetyl-CoA C-myristoyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3194209

Title: Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase.

PubMed ID: 3194209

DOI: 10.1093/nar/16.21.10369

PubMed ID: 2726492

Title: Complete cDNA sequence of human foetal liver peroxisomal 3-oxoacyl-CoA thiolase.

PubMed ID: 2726492

DOI: 10.1093/nar/17.9.3588

PubMed ID: 1679347

Title: Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient.

PubMed ID: 1679347

DOI: 10.1016/0167-4781(91)90035-k

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2882519

Title: Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency.

PubMed ID: 2882519

DOI: 10.1073/pnas.84.8.2494

PubMed ID: 11734571

Title: Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.

PubMed ID: 11734571

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22057399

Title: Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.

PubMed ID: 22057399

DOI: 10.1074/jbc.m111.301853

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25538232

Title: Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.

PubMed ID: 25538232

DOI: 10.1074/jbc.m114.601575

Sequence Information:

  • Length: 424
  • Mass: 44292
  • Checksum: 71B2BBAFA06AE412
  • Sequence:
  • MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT 
    PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN 
    RQCSSGLQAV ASIAGGIRNG SYDIGMACGV ESMSLADRGN PGNITSRLME KEKARDCLIP 
    MGITSENVAE RFGISREKQD TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI 
    TVTQDEGIRP STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI 
    LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS QAAYCVEKLR 
    LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR AYGVVSMCIG TGMGAAAVFE 
    YPGN

Genular Protein ID: 2951958359

Symbol: A0A140VJX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 331
  • Mass: 34665
  • Checksum: 8137A0AC448FBA24
  • Sequence:
  • MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT 
    PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN 
    RQCSSGLQAV ASIAGGIRNG SYDIGMACGI TSENVAERFG ISREKQDTFA LASQQKAARA 
    QSKGCFQAEI VPVTTTVHDD KGTKRSITVT QDEGIRPSTT MEGLAKLKPA FKKDGSTTAG 
    LTVSDVDIFE INEAFASQAA YCVEKLRLPP EKVNPLGGAV ALGHPLGCTG ARQVITLLNE 
    LKRRGKRAYG VVSMCIGTGM GAAAVFEYPG N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.