Details for: Pcsk1n

Gene ID: 30052

Symbol: Pcsk1n

Ensembl ID: ENSMUSG00000039278

Description: proprotein convertase subtilisin/kexin type 1 inhibitor

Associated with

Other Information

Genular Protein ID: 2248996032

Symbol: PCS1N_MOUSE

Name: ProSAAS

UniProtKB Accession Codes:

Q9QXV0 Q91W26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CPTAC 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 GO 9 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MEROPS 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10632593

Title: Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.

PubMed ID: 10632593

DOI: 10.1523/jneurosci.20-02-00639.2000

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9756897

Title: Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.

PubMed ID: 9756897

DOI: 10.1074/jbc.273.41.26589

PubMed ID: 9630436

Title: Molecular cloning and characterization of a highly basic protein, IA-4, expressed in pancreatic islets and brain.

PubMed ID: 9630436

DOI: 10.1159/000054314

PubMed ID: 11094058

Title: ProSAAS processing in mouse brain and pituitary.

PubMed ID: 11094058

DOI: 10.1074/jbc.m009067200

PubMed ID: 11259501

Title: Tissue distribution and processing of proSAAS by proprotein convertases.

PubMed ID: 11259501

DOI: 10.1046/j.1471-4159.2001.00165.x

PubMed ID: 11742530

Title: Processing of proSAAS in neuroendocrine cell lines.

PubMed ID: 11742530

DOI: 10.1042/0264-6021:3610067

PubMed ID: 15018810

Title: ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.

PubMed ID: 15018810

DOI: 10.1016/s1567-133x(02)00002-9

PubMed ID: 11719503

Title: Functional characterization of ProSAAS: similarities and differences with 7B2.

PubMed ID: 11719503

DOI: 10.1074/jbc.m104531200

PubMed ID: 16631141

Title: Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress.

PubMed ID: 16631141

DOI: 10.1016/j.brainres.2006.02.124

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24043826

Title: GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

PubMed ID: 24043826

DOI: 10.1073/pnas.1312938110

PubMed ID: 27117253

Title: Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

PubMed ID: 27117253

DOI: 10.1126/scisignal.aad0694

Sequence Information:

  • Length: 258
  • Mass: 27270
  • Checksum: 4197C8B077A20A22
  • Sequence:
    • MAGSPLLCGP RAGGVGILVL LLLGLLRLPP TLSARPVKEP RSLSAASAPL VETSTPLRLR 
RAVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RAWGSPRASD 
PPLAPDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPAA APRPRPPVYD DGPTGPDVED 
AGDETPDVDP ELLRYLLGRI LTGSSEPEAA PAPRRLRRSV DQDLGPEVPP ENVLGALLRV 
KRLENPSPQA PARRLLPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.