fgf8a | ENSDARG00000003399 | NCBI 30538

Details for: fgf8a

Gene ID: 30538

Symbol: fgf8a

Ensembl ID: ENSDARG00000003399

Description: fibroblast growth factor 8a

Associated with

Downstream signaling of activated fgfr1
(R-DRE-5654687)
Downstream signaling of activated fgfr2
(R-DRE-5654696)
Downstream signaling of activated fgfr3
(R-DRE-5654708)
Downstream signaling of activated fgfr4
(R-DRE-5654716)
Fgfr1 ligand binding and activation
(R-DRE-190242)
Fgfr1c ligand binding and activation
(R-DRE-190373)
Fgfr2 ligand binding and activation
(R-DRE-190241)
Fgfr2c ligand binding and activation
(R-DRE-190375)
Fgfr3 ligand binding and activation
(R-DRE-190239)
Fgfr3b ligand binding and activation
(R-DRE-190371)
Fgfr3c ligand binding and activation
(R-DRE-190372)
Fgfr4 ligand binding and activation
(R-DRE-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-DRE-5658623)
Frs-mediated fgfr1 signaling
(R-DRE-5654693)
Frs-mediated fgfr2 signaling
(R-DRE-5654700)
Frs-mediated fgfr3 signaling
(R-DRE-5654706)
Frs-mediated fgfr4 signaling
(R-DRE-5654712)
Intracellular signaling by second messengers
(R-DRE-9006925)
Mapk1/mapk3 signaling
(R-DRE-5684996)
Mapk family signaling cascades
(R-DRE-5683057)
Negative regulation of fgfr1 signaling
(R-DRE-5654726)
Negative regulation of the pi3k/akt network
(R-DRE-199418)
Phospholipase c-mediated cascade: fgfr1
(R-DRE-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-DRE-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-DRE-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-DRE-5654228)
Pi-3k cascade:fgfr1
(R-DRE-5654689)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-DRE-6811558)
Pip3 activates akt signaling
(R-DRE-1257604)
Raf/map kinase cascade
(R-DRE-5673001)
Shc-mediated cascade:fgfr1
(R-DRE-5654688)
Shc-mediated cascade:fgfr2
(R-DRE-5654699)
Shc-mediated cascade:fgfr3
(R-DRE-5654704)
Signaling by fgfr
(R-DRE-190236)
Signaling by fgfr1
(R-DRE-5654736)
Signaling by fgfr2
(R-DRE-5654738)
Signaling by fgfr3
(R-DRE-5654741)
Signaling by fgfr4
(R-DRE-5654743)
Signaling by receptor tyrosine kinases
(R-DRE-9006934)
Signal transduction
(R-DRE-162582)
Animal organ morphogenesis
(GO:0009887)
Anterior/posterior pattern specification
(GO:0009952)
Brain development
(GO:0007420)
Cardiac ventricle morphogenesis
(GO:0003208)
Cardioblast differentiation
(GO:0010002)
Cell fate specification
(GO:0001708)
Cerebellum development
(GO:0021549)
Cerebellum formation
(GO:0021588)
Determination of dorsal identity
(GO:0048263)
Determination of left/right symmetry
(GO:0007368)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic camera-type eye development
(GO:0031076)
Embryonic heart tube development
(GO:0035050)
Embryonic pattern specification
(GO:0009880)
Endoderm development
(GO:0007492)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heart morphogenesis
(GO:0003007)
Hindbrain development
(GO:0030902)
Locus ceruleus development
(GO:0021703)
Mesoderm development
(GO:0007498)
Midbrain-hindbrain boundary development
(GO:0030917)
Midbrain-hindbrain boundary morphogenesis
(GO:0021555)
Midbrain development
(GO:0030901)
Negative regulation of endodermal cell fate specification
(GO:0042664)
Neuron differentiation
(GO:0030182)
Neuron fate specification
(GO:0048665)
Notochord development
(GO:0030903)
Otic placode formation
(GO:0043049)
Otic vesicle formation
(GO:0030916)
Paraxial mesoderm development
(GO:0048339)
Peripheral nervous system development
(GO:0007422)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of somitomeric trunk muscle development
(GO:0014709)
Positive regulation of wnt signaling pathway
(GO:0030177)
Regulation of bone remodeling
(GO:0046850)
Regulation of cell migration
(GO:0030334)
Rhombomere 5 development
(GO:0021571)
Rhombomere 6 development
(GO:0021572)
Somitogenesis
(GO:0001756)
Thyroid gland development
(GO:0030878)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)

Other Information

Proteins

Fibroblast growth factor 8

Genular Protein ID: 2608904869

Symbol: FGF8A_DANRE

Name: Fibroblast growth factor 8

UniProtKB Accession Codes:

O57341 Q5PRC3

Database IDs:

Citations:

PubMed ID: 9334274

Title: A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula.

PubMed ID: 9334274

DOI: 10.1242/dev.124.21.4253

PubMed ID: 9609821

Title: Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.

PubMed ID: 9609821

DOI: 10.1242/dev.125.13.2381

PubMed ID: 23594743

Title: The zebrafish reference genome sequence and its relationship to the human genome.

PubMed ID: 23594743

DOI: 10.1038/nature12111

PubMed ID: 19164561

Title: FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1.

PubMed ID: 19164561

DOI: 10.1073/pnas.0812880106

Sequence Information:

Length: 210
Mass: 24697
Checksum: 9D9CA5B8E18A435A
Sequence:

MRLIPSRLSY LFLHLFAFCY YAQVTIQSPP NFTQHVSEQS KVTDRVSRRL IRTYQLYSRT 
SGKHVQVLAN KKINAMAEDG DVHAKLIVET DTFGSRVRIK GAETGFYICM NRRGKLIGKK 
NGLGKDCIFT EIVLENNYTA LQNVKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK 
GHQIAEHRPF DFINYPFNRR TKRTRYSGER

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: fgf8a

Associated with

Other Information

A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. PubMed ID: 9334274

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. PubMed ID: 9609821

The zebrafish reference genome sequence and its relationship to the human genome. PubMed ID: 23594743

FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. PubMed ID: 19164561

Database document:

PubMed ID: 9334274

PubMed ID: 9609821

PubMed ID: 23594743

PubMed ID: 19164561