Details for: ANXA3

Gene ID: 306

Symbol: ANXA3

Ensembl ID: ENSG00000138772

Description: annexin A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.99
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-dependent protein binding**: ANXA3 binds to calcium ions, which modulates its interaction with other proteins, influencing its function in cellular processes. 2. **Phospholipid binding**: ANXA3 binds to phospholipids, including phosphatidylserine, which is involved in cell signaling, membrane trafficking, and apoptosis. 3. **Anti-inflammatory properties**: ANXA3 has been shown to inhibit phospholipase A2, reducing inflammation and oxidative stress in various cell types. 4. **Cell membrane localization**: ANXA3 is primarily localized to the cell membrane, where it interacts with other membrane proteins and lipids. **Pathways and Functions:** 1. **Cell signaling**: ANXA3 interacts with various signaling molecules, including growth factors, cytokines, and hormones, influencing cellular responses to environmental stimuli. 2. **Immune response**: ANXA3 plays a role in the regulation of immune responses, including neutrophil degranulation, phagocytosis, and defense against bacterial infections. 3. **Membrane trafficking**: ANXA3 is involved in the regulation of membrane trafficking, including endocytosis, exocytosis, and membrane fusion. 4. **Apoptosis regulation**: ANXA3 has been shown to modulate apoptosis, influencing the regulation of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** 1. **Respiratory diseases**: ANXA3 has been implicated in the pathogenesis of respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. 2. **Cardiovascular diseases**: ANXA3 has been linked to cardiovascular diseases, including myocardial infarction, atherosclerosis, and cardiac arrhythmias. 3. **Neurological disorders**: ANXA3 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cancer**: ANXA3 has been shown to play a role in cancer development and progression, including breast cancer, lung cancer, and colon cancer. In conclusion, ANXA3 is a multifunctional protein that plays a critical role in various cellular processes, including cell signaling, immune response, membrane trafficking, and apoptosis regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying ANXA3 function and its role in disease pathology. **References:** * [Insert relevant references to support the discussion] Note: As an expert immunologist, the discussion is written in a detailed and technical manner, with a focus on the key characteristics, pathways, and functions of ANXA3, as well as its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.