Details for: ANXA3

Gene ID: 306

Symbol: ANXA3

Ensembl ID: ENSG00000138772

Description: annexin A3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.91
    Marker Score: 4716
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.18
    Marker Score: 4596
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.34
    Marker Score: 1395
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.29
    Marker Score: 20138.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.24
    Marker Score: 797
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.18
    Marker Score: 1704
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.12
    Marker Score: 1168
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.05
    Marker Score: 2129
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.05
    Marker Score: 657.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7302
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.84
    Marker Score: 4665
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.83
    Marker Score: 581
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.8
    Marker Score: 754.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.74
    Marker Score: 8524
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.68
    Marker Score: 2982
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.67
    Marker Score: 780
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.64
    Marker Score: 3728
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.6
    Marker Score: 1426.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.53
    Marker Score: 3488
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.51
    Marker Score: 9648
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.48
    Marker Score: 1276
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168003
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.46
    Marker Score: 12577
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.44
    Marker Score: 648
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 983
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.43
    Marker Score: 23019
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.42
    Marker Score: 5483
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.34
    Marker Score: 1614.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.33
    Marker Score: 775
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.3
    Marker Score: 2367
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.27
    Marker Score: 43869
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.21
    Marker Score: 1048
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.21
    Marker Score: 237
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2286
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.18
    Marker Score: 470
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.16
    Marker Score: 574
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.13
    Marker Score: 2853
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.1
    Marker Score: 920
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.09
    Marker Score: 315
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.07
    Marker Score: 8339
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.07
    Marker Score: 2606
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1074
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.05
    Marker Score: 337
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.04
    Marker Score: 5455
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251772
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2081
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.02
    Marker Score: 442
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.02
    Marker Score: 4248
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.01
    Marker Score: 368
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.01
    Marker Score: 243
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.01
    Marker Score: 404
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1
    Marker Score: 1660
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71792.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48017
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.99
    Marker Score: 1437
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.97
    Marker Score: 367.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.97
    Marker Score: 1128.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.96
    Marker Score: 3016
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.95
    Marker Score: 4577
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1534
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.94
    Marker Score: 626
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.94
    Marker Score: 308
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.93
    Marker Score: 238
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.93
    Marker Score: 2192
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5308
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.9
    Marker Score: 1426
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.9
    Marker Score: 963
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.89
    Marker Score: 2427
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 421
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13833
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.88
    Marker Score: 931
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 667
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.86
    Marker Score: 355.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1063
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.85
    Marker Score: 520
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.84
    Marker Score: 1381
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.84
    Marker Score: 1995
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 331.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.77
    Marker Score: 1084
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.75
    Marker Score: 1207
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 806
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.75
    Marker Score: 10040
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.74
    Marker Score: 257
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.74
    Marker Score: 365
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.74
    Marker Score: 359
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 472
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.73
    Marker Score: 2598
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.73
    Marker Score: 383
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.73
    Marker Score: 710
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.72
    Marker Score: 502

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Other Information

**Key characteristics:** - Annexin A3 is a transmembrane protein that is found in the cytoplasm of cells. - It is a member of the annexin family of proteins, which are involved in cell adhesion, signaling, and migration. - Annexin A3 is a calcium-dependent protein that is expressed in high levels in endothelial cells. - It is involved in the regulation of angiogenesis, cell migration, and inflammation. **Pathways and functions:** - Annexin A3 is involved in the regulation of angiogenesis by binding to the extracellular matrix protein fibronectin and promoting the formation of new blood vessels. - It is also involved in the regulation of cell migration by binding to the integrin receptor and promoting cell adhesion to extracellular matrix proteins. - Annexin A3 is also involved in the regulation of inflammation by binding to inflammatory cytokines and promoting the production of inflammatory cytokines. **Clinical significance:** - Mutations in the ANXA3 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - Annexin A3 is a potential target for the development of new therapies for these diseases. **Additional notes:** - Annexin A3 is a highly conserved protein that is found in organisms from yeast to humans. - It is a well-studied protein that has been extensively characterized in model systems. - Annexin A3 is a promising target for the development of new drugs for a variety of human diseases.

Genular Protein ID: 847741413

Symbol: ANXA3_HUMAN

Name: Annexin A3

UniProtKB Accession Codes:

P12429 B2R9W6 Q6LET2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2968983

Title: Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

PubMed ID: 2968983

DOI: 10.1016/s0021-9258(18)38041-4

PubMed ID: 1830024

Title: Chromosomal localization of the human annexin III (ANX3) gene.

PubMed ID: 1830024

DOI: 10.1016/0888-7543(91)90330-h

PubMed ID: 8276419

Title: Structure and polymorphisms of the human annexin III (ANX3) gene.

PubMed ID: 8276419

DOI: 10.1006/geno.1993.1428

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2159184

Title: Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III.

PubMed ID: 2159184

DOI: 10.1126/science.2159184

PubMed ID: 2975506

Title: Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family.

PubMed ID: 2975506

DOI: 10.1021/bi00417a011

PubMed ID: 2138632

Title: Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules.

PubMed ID: 2138632

DOI: 10.1172/jci114537

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8639653

Title: The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.

PubMed ID: 8639653

DOI: 10.1021/bi952092o

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 323
  • Mass: 36375
  • Checksum: 4128C715491FC132
  • Sequence:
    • MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY 
QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK KSMKGAGTNE DALIEILTTR 
TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQ 
ILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL 
LAIVNCVRNT PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY 
SAIKSDTSGD YEITLLKICG GDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.