Details for: cd74b

Gene ID: 30645

Symbol: cd74b

Ensembl ID: ENSDARG00000036628

Description: CD74 molecule, major histocompatibility complex, class II invariant chain b

Associated with

  • Antigen processing and presentation
    (GO:0019882)
  • Cell surface
    (GO:0009986)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytoplasm
    (GO:0005737)
  • Immune response
    (GO:0006955)
  • Inner ear development
    (GO:0048839)
  • Intracellular protein transport
    (GO:0006886)
  • Macrophage migration inhibitory factor binding
    (GO:0035718)
  • Membrane
    (GO:0016020)
  • Mhc class ii protein binding
    (GO:0042289)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:1902166)
  • Neuromast development
    (GO:0048884)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of type 2 immune response
    (GO:0002830)
  • T cell activation involved in immune response
    (GO:0002286)

Other Information

Genular Protein ID: 4215514511

Symbol: Q9PVD9_DANRE

Name: N/A

UniProtKB Accession Codes:

Q9PVD9 A1L140

Database IDs:

ARBA 2 Bgee 1 CDD 1 CTD 1 EMBL 7 Ensembl 2 GO 18 Gene3D 1 HOGENOM 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 2 Proteomes 2 RefSeq 2 SAM 2 SMART 1 STRING 1 SUPFAM 1 ZFIN 2 eggNOG 1

Citations:

PubMed ID: 10541812

Title: Cloning of two zebrafish cDNAs that share domains with the MHC class II-associated invariant chain.

PubMed ID: 10541812

DOI: 10.1007/s002510050691

PubMed ID: 18803863

Title: Analysis of the goldfish Carassius auratus olfactory epithelium transcriptome reveals the presence of numerous non-olfactory GPCR and putative receptors for progestin pheromones.

PubMed ID: 18803863

PubMed ID: 19504456

Title: Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos.

PubMed ID: 19504456

DOI: 10.1002/dvdy.21990

PubMed ID: 21042590

Title: Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants.

PubMed ID: 21042590

PubMed ID: 22210003

Title: The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio.

PubMed ID: 22210003

PubMed ID: 22438865

Title: Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish.

PubMed ID: 22438865

PubMed ID: 23594743

Title: The zebrafish reference genome sequence and its relationship to the human genome.

PubMed ID: 23594743

DOI: 10.1038/nature12111

PubMed ID: 27834691

Title: Zebrafish Model for Functional Screening of Flow-Responsive Genes.

PubMed ID: 27834691

PubMed ID: 28698226

Title: Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.

PubMed ID: 28698226

PubMed ID: 27757989

Title: Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish.

PubMed ID: 27757989

PubMed ID: 30885554

Title: The negative regulation of piscine CD44c in viral and bacterial infection.

PubMed ID: 30885554

DOI: .1016/j.dci.2019.03.005

PubMed ID: 30377750

Title: Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules.

PubMed ID: 30377750

Sequence Information:

  • Length: 198
  • Mass: 21959
  • Checksum: 72E37EA2B2EA7370
  • Sequence:
    • MSSEGNETPL ISDQSSVNMG PQPRNKNQAL KVAGVTLLAG ILIAGQAFTA YMAYSHKEQL 
NTLERRGDRL HEISRKSAMR APLKMHLPMS SLALKYEDDT KENKDSPPSS PKPEPKVLTQ 
CQKEAAGEVK SLLPSFKPRC NENGDYLSQQ CWEQTDFCWC VDKNGVEIPD TLKEGPAQCW 
ALNSADIVNE PLLRKNGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.