psmb8a | ENSDARG00000001303 | NCBI 30666

Details for: psmb8a

Gene ID: 30666

Symbol: psmb8a

Ensembl ID: ENSDARG00000001303

Description: proteasome 20S subunit beta 8A

Associated with

Abc-family proteins mediated transport
(R-DRE-382556)
Activation of nf-kappab in b cells
(R-DRE-1169091)
Adaptive immune system
(R-DRE-1280218)
Antigen processing-cross presentation
(R-DRE-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-DRE-983168)
Assembly of the pre-replicative complex
(R-DRE-68867)
Asymmetric localization of pcp proteins
(R-DRE-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-DRE-450408)
Autodegradation of the e3 ubiquitin ligase cop1
(R-DRE-349425)
Beta-catenin independent wnt signaling
(R-DRE-3858494)
Cdk-mediated phosphorylation and removal of cdc6
(R-DRE-69017)
Cell cycle
(R-DRE-1640170)
Cell cycle, mitotic
(R-DRE-69278)
Cell cycle checkpoints
(R-DRE-69620)
Cellular responses to stimuli
(R-DRE-8953897)
Cellular responses to stress
(R-DRE-2262752)
Cellular response to chemical stress
(R-DRE-9711123)
Class i mhc mediated antigen processing & presentation
(R-DRE-983169)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-DRE-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-DRE-69656)
Cyclin e associated events during g1/s transition
(R-DRE-69202)
Degradation of axin
(R-DRE-4641257)
Degradation of dvl
(R-DRE-4641258)
Degradation of gli1 by the proteasome
(R-DRE-5610780)
Deubiquitination
(R-DRE-5688426)
Dna replication
(R-DRE-69306)
Dna replication pre-initiation
(R-DRE-69002)
Downstream signaling events of b cell receptor (bcr)
(R-DRE-1168372)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-DRE-8854050)
G1/s dna damage checkpoints
(R-DRE-69615)
G1/s transition
(R-DRE-69206)
G2/m checkpoints
(R-DRE-69481)
G2/m transition
(R-DRE-69275)
Gene expression (transcription)
(R-DRE-74160)
Generic transcription pathway
(R-DRE-212436)
Gli3 is processed to gli3r by the proteasome
(R-DRE-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-DRE-9762114)
Hedgehog 'off' state
(R-DRE-5610787)
Hedgehog 'on' state
(R-DRE-5632684)
Hedgehog ligand biogenesis
(R-DRE-5358346)
Immune system
(R-DRE-168256)
Intracellular signaling by second messengers
(R-DRE-9006925)
Keap1-nfe2l2 pathway
(R-DRE-9755511)
Mapk6/mapk4 signaling
(R-DRE-5687128)
Mapk family signaling cascades
(R-DRE-5683057)
Metabolism
(R-DRE-1430728)
Metabolism of amino acids and derivatives
(R-DRE-71291)
Metabolism of polyamines
(R-DRE-351202)
Metabolism of proteins
(R-DRE-392499)
Metabolism of rna
(R-DRE-8953854)
Mitotic g1 phase and g1/s transition
(R-DRE-453279)
Mitotic g2-g2/m phases
(R-DRE-453274)
Neddylation
(R-DRE-8951664)
Nuclear events mediated by nfe2l2
(R-DRE-9759194)
P53-dependent g1 dna damage response
(R-DRE-69563)
P53-dependent g1/s dna damage checkpoint
(R-DRE-69580)
Pcp/ce pathway
(R-DRE-4086400)
Pip3 activates akt signaling
(R-DRE-1257604)
Post-translational protein modification
(R-DRE-597592)
Pten regulation
(R-DRE-6807070)
Regulation of mrna stability by proteins that bind au-rich elements
(R-DRE-450531)
Regulation of ornithine decarboxylase (odc)
(R-DRE-350562)
Regulation of pten stability and activity
(R-DRE-8948751)
Regulation of runx2 expression and activity
(R-DRE-8939902)
Regulation of runx3 expression and activity
(R-DRE-8941858)
Rna polymerase ii transcription
(R-DRE-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-DRE-8939236)
Scf(skp2)-mediated degradation of p27/p21
(R-DRE-187577)
Signaling by hedgehog
(R-DRE-5358351)
Signaling by the b cell receptor (bcr)
(R-DRE-983705)
Signaling by wnt
(R-DRE-195721)
Signal transduction
(R-DRE-162582)
S phase
(R-DRE-69242)
Stabilization of p53
(R-DRE-69541)
Switching of origins to a post-replicative state
(R-DRE-69052)
Synthesis of dna
(R-DRE-69239)
Tcf dependent signaling in response to wnt
(R-DRE-201681)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-DRE-8852276)
Transcriptional regulation by runx1
(R-DRE-8878171)
Transcriptional regulation by runx2
(R-DRE-8878166)
Transcriptional regulation by runx3
(R-DRE-8878159)
Transport of small molecules
(R-DRE-382551)
Ub-specific processing proteases
(R-DRE-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-DRE-75815)
Uch proteinases
(R-DRE-5689603)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Proteasome complex
(GO:0000502)
Proteasome core complex
(GO:0005839)
Proteasome core complex, beta-subunit complex
(GO:0019774)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Threonine-type endopeptidase activity
(GO:0004298)

Other Information

Proteins

O57330_DANRE

Genular Protein ID: 2905813721

Symbol: O57330_DANRE

Name: N/A

UniProtKB Accession Codes:

O57330 B3DHT7 F6NLG9

Database IDs:

Citations:

PubMed ID: 9550404

Title: Linkage of LMP, TAP, and RING3 with Mhc class I rather than class II genes in the zebrafish.

PubMed ID: 9550404

PubMed ID: 10453006

Title: Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes.

PubMed ID: 10453006

PubMed ID: 11814690

Title: Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences.

PubMed ID: 11814690

DOI: 10.1016/S0378-1119(01)00834-4

PubMed ID: 12598696

Title: Molecular phylogeny of early vertebrates: monophyly of the agnathans as revealed by sequences of 35 genes.

PubMed ID: 12598696

DOI: 10.1093/molbev/msg040

PubMed ID: 20102740

Title: Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide.

PubMed ID: 20102740

DOI: 10.1016/j.matbio.2010.01.006

PubMed ID: 21346254

Title: Characterization of immune-matched hematopoietic transplantation in zebrafish.

PubMed ID: 21346254

PubMed ID: 23594743

Title: The zebrafish reference genome sequence and its relationship to the human genome.

PubMed ID: 23594743

DOI: 10.1038/nature12111

PubMed ID: 24683187

Title: Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

PubMed ID: 24683187

PubMed ID: 26469318

Title: RFX transcription factors are essential for hearing in mice.

PubMed ID: 26469318

PubMed ID: 27493218

Title: Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution.

PubMed ID: 27493218

PubMed ID: 28698226

Title: Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.

PubMed ID: 28698226

PubMed ID: 29471808

Title: Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules.

PubMed ID: 29471808

Sequence Information:

Length: 271
Mass: 30086
Checksum: 3233966FCEE07DB5
Sequence:

MALLDVSGYK YNSASQFGFK QTLLDRSNHY SFGTKCQEFA VPVGVDPSKF LKSCSCEDGV 
CIDLNHGTTT LAFKFRHGVI VAVDSRASAG KYIASKEANK VIEINPYLLG TMSGSAADCQ 
YWERLLAKEC RLYKLRNKQR ISVSAASKLL SNMMLGYRGM GLSMGSMICG WDKQGPGLYY 
VDDNGTRLSG RMFSTGCGNS YAYGVVDSGY REDMTVEEAY ELGRRGIAHA THRDAYSGGV 
VNLYHMQEDG WIKVCKEDVS ELIHRYKKGM F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: psmb8a

Associated with

Other Information

Linkage of LMP, TAP, and RING3 with Mhc class I rather than class II genes in the zebrafish. PubMed ID: 9550404

Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes. PubMed ID: 10453006

Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences. PubMed ID: 11814690

Molecular phylogeny of early vertebrates: monophyly of the agnathans as revealed by sequences of 35 genes. PubMed ID: 12598696

Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide. PubMed ID: 20102740

Characterization of immune-matched hematopoietic transplantation in zebrafish. PubMed ID: 21346254

The zebrafish reference genome sequence and its relationship to the human genome. PubMed ID: 23594743

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. PubMed ID: 24683187

RFX transcription factors are essential for hearing in mice. PubMed ID: 26469318

Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. PubMed ID: 27493218

Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. PubMed ID: 28698226

Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. PubMed ID: 29471808