Details for: ANXA4

Gene ID: 307

Symbol: ANXA4

Ensembl ID: ENSG00000196975

Description: annexin A4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 336.4616
    Cell Significance Index: -52.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.0650
    Cell Significance Index: -45.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 133.2208
    Cell Significance Index: -54.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.7611
    Cell Significance Index: -45.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.4859
    Cell Significance Index: -52.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.9288
    Cell Significance Index: -50.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.3804
    Cell Significance Index: -52.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.8090
    Cell Significance Index: -46.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.6090
    Cell Significance Index: -52.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7613
    Cell Significance Index: -47.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.7727
    Cell Significance Index: -34.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1887
    Cell Significance Index: -43.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4134
    Cell Significance Index: -52.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.7594
    Cell Significance Index: 38.0000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.9788
    Cell Significance Index: 14.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.8975
    Cell Significance Index: 104.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1553
    Cell Significance Index: 1723.1900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.3682
    Cell Significance Index: 23.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1556
    Cell Significance Index: 19.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6787
    Cell Significance Index: 333.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6698
    Cell Significance Index: 32.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6031
    Cell Significance Index: 34.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5951
    Cell Significance Index: 157.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5847
    Cell Significance Index: 82.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3239
    Cell Significance Index: 36.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3025
    Cell Significance Index: 32.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2750
    Cell Significance Index: 156.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2357
    Cell Significance Index: 16.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1853
    Cell Significance Index: 14.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1317
    Cell Significance Index: 204.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0478
    Cell Significance Index: 80.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9617
    Cell Significance Index: 132.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8686
    Cell Significance Index: 25.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7554
    Cell Significance Index: 20.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7390
    Cell Significance Index: 37.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7141
    Cell Significance Index: 315.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6637
    Cell Significance Index: 41.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6413
    Cell Significance Index: 128.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6230
    Cell Significance Index: 9.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5021
    Cell Significance Index: 54.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4909
    Cell Significance Index: 3.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4902
    Cell Significance Index: 13.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3686
    Cell Significance Index: 47.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3402
    Cell Significance Index: 64.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3372
    Cell Significance Index: 15.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3328
    Cell Significance Index: 24.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3019
    Cell Significance Index: 7.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2606
    Cell Significance Index: 5.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2515
    Cell Significance Index: 11.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2222
    Cell Significance Index: 37.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2142
    Cell Significance Index: 76.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1579
    Cell Significance Index: 20.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1363
    Cell Significance Index: 7.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1360
    Cell Significance Index: 255.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1104
    Cell Significance Index: 83.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1103
    Cell Significance Index: 7.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0871
    Cell Significance Index: 55.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0733
    Cell Significance Index: 112.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0699
    Cell Significance Index: 128.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0691
    Cell Significance Index: 3.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0591
    Cell Significance Index: 1.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0579
    Cell Significance Index: 1.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0490
    Cell Significance Index: 35.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0338
    Cell Significance Index: 45.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0209
    Cell Significance Index: 14.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0104
    Cell Significance Index: 4.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0068
    Cell Significance Index: 0.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0061
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0251
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0376
    Cell Significance Index: -1.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0658
    Cell Significance Index: -37.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1195
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1448
    Cell Significance Index: -41.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1452
    Cell Significance Index: -30.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1514
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1569
    Cell Significance Index: -17.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1793
    Cell Significance Index: -26.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2110
    Cell Significance Index: -3.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2429
    Cell Significance Index: -28.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2608
    Cell Significance Index: -2.7000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2711
    Cell Significance Index: -2.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2723
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2936
    Cell Significance Index: -33.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3185
    Cell Significance Index: -37.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3334
    Cell Significance Index: -26.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3956
    Cell Significance Index: -41.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4250
    Cell Significance Index: -26.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4492
    Cell Significance Index: -25.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4562
    Cell Significance Index: -7.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4977
    Cell Significance Index: -8.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5877
    Cell Significance Index: -39.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6127
    Cell Significance Index: -16.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6157
    Cell Significance Index: -9.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6222
    Cell Significance Index: -27.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6524
    Cell Significance Index: -22.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7362
    Cell Significance Index: -15.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7379
    Cell Significance Index: -18.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7420
    Cell Significance Index: -21.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANXA4 is a 35-kDa protein that belongs to the annexin family, which is characterized by its ability to bind to phospholipids, proteins, and other molecules. The protein exhibits a high degree of calcium-dependent binding activity, which is essential for its function in various cellular processes. ANXA4 has been shown to interact with a wide range of molecules, including phospholipases, kinases, and transcription factors, thereby modulating various signaling pathways. The protein's ability to inhibit phospholipase activity makes it a potential regulator of cellular processes, including inflammation and apoptosis. **Pathways and Functions:** ANXA4 is involved in several cellular pathways, including: 1. **Calcium-dependent phospholipid binding:** ANXA4 binds to phospholipids, such as phosphatidylserine, which is a key component of cell membranes. 2. **Calcium-dependent protein binding:** ANXA4 interacts with various proteins, including kinases, phospholipases, and transcription factors, thereby modulating signaling pathways. 3. **Negative regulation of apoptotic process:** ANXA4 inhibits apoptosis by interacting with pro-apoptotic proteins and modulating signaling pathways. 4. **Negative regulation of interleukin-8 production:** ANXA4 inhibits the production of interleukin-8, a pro-inflammatory cytokine, thereby regulating inflammation. 5. **Regulation of transcription by RNA polymerase II:** ANXA4 interacts with RNA polymerase II, thereby regulating gene expression. **Clinical Significance:** The clinical significance of ANXA4 lies in its potential role in the regulation of immune responses, including the negative regulation of apoptotic processes and the inhibition of interleukin-8 production. Dysregulation of ANXA4 has been implicated in various diseases, including: 1. **Autoimmune disorders:** ANXA4 has been shown to play a role in the regulation of immune responses in autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** ANXA4 has been implicated in the regulation of apoptosis and cell differentiation in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** ANXA4 has been shown to play a role in the regulation of immune responses in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, ANXA4 is a multifaceted protein that plays a crucial role in various cellular processes, including cell signaling, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the clinical significance of ANXA4.

Genular Protein ID: 3662417172

Symbol: ANXA4_HUMAN

Name: 35-beta calcimedin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2970257

Title: Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family.

PubMed ID: 2970257

PubMed ID: 1346776

Title: Chromosomal mapping of the human annexin IV (ANX4) gene.

PubMed ID: 1346776

DOI: 10.1016/0888-7543(92)90379-7

PubMed ID: 9084877

Title: Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17.

PubMed ID: 9084877

DOI: 10.1248/bpb.20.224

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2975506

Title: Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family.

PubMed ID: 2975506

DOI: 10.1021/bi00417a011

PubMed ID: 2974032

Title: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor.

PubMed ID: 2974032

DOI: 10.1016/s0021-9258(18)37335-6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2254922

Title: Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV.

PubMed ID: 2254922

DOI: 10.1016/s0022-2836(05)80310-9

Sequence Information:

  • Length: 319
  • Mass: 35883
  • Checksum: 3799FE80A93AB215
  • Sequence:
  • MATKGGTVKA ASGFNAMEDA QTLRKAMKGL GTDEDAIISV LAYRNTAQRQ EIRTAYKSTI 
    GRDLIDDLKS ELSGNFEQVI VGMMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRTPEE 
    IRRISQTYQQ QYGRSLEDDI RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE 
    AGEKKWGTDE VKFLTVLCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 
    KCMRNKSAYF AEKLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK 
    GDTSGDYRKV LLVLCGGDD

Genular Protein ID: 2036103935

Symbol: Q6P452_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 299
  • Mass: 33552
  • Checksum: CB81FAA4E951DA56
  • Sequence:
  • MAMATKGGTV KAASGFNAME DAQTLRKAMK GLGTDEDAII SVLAYRNTAQ RQEIRTAYKS 
    TIGRDLIDDL KSELSGNFEQ GAGTDEGCLI EILASRTPEE IRRISQTYQQ QYGRSLEDDI 
    RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE AGEKKWGTDE VKFLTVLCSR 
    NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF AEKLYKSMKG 
    LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK GDTSGDYRKV LLVLCGGDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.