Details for: ANXA4

Gene ID: 307

Symbol: ANXA4

Ensembl ID: ENSG00000196975

Description: annexin A4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.02
    Marker Score: 5004
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 94886.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.66
    Marker Score: 12770
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.64
    Marker Score: 2738
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.62
    Marker Score: 9299
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.44
    Marker Score: 7667.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.42
    Marker Score: 1289.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.36
    Marker Score: 5941
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.27
    Marker Score: 2739
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.23
    Marker Score: 3434
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.23
    Marker Score: 2259
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.21
    Marker Score: 14086
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.16
    Marker Score: 3436
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.16
    Marker Score: 1136
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.12
    Marker Score: 18450
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1
    Marker Score: 33703
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.09
    Marker Score: 3358
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.04
    Marker Score: 763
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.02
    Marker Score: 5417
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.01
    Marker Score: 4571
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2
    Marker Score: 1102
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2934
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.93
    Marker Score: 2050
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.92
    Marker Score: 4562
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.91
    Marker Score: 12469
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.9
    Marker Score: 1823
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.86
    Marker Score: 47759
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.85
    Marker Score: 1306
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.85
    Marker Score: 533
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.84
    Marker Score: 947
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.8
    Marker Score: 856
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.78
    Marker Score: 2150
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.78
    Marker Score: 1188
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.75
    Marker Score: 353
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.74
    Marker Score: 502
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.72
    Marker Score: 4680
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.72
    Marker Score: 1851
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.71
    Marker Score: 2806
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.69
    Marker Score: 37804
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.67
    Marker Score: 1950
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.66
    Marker Score: 2140
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.65
    Marker Score: 3362
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.64
    Marker Score: 777
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.62
    Marker Score: 34674
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.62
    Marker Score: 3112
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.59
    Marker Score: 460
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.59
    Marker Score: 365
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.57
    Marker Score: 704
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.57
    Marker Score: 8247
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.56
    Marker Score: 777
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.56
    Marker Score: 2211
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.55
    Marker Score: 4062
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.55
    Marker Score: 2746
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.54
    Marker Score: 361
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.54
    Marker Score: 579
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5
    Marker Score: 1575
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.49
    Marker Score: 2718
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.47
    Marker Score: 1020
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.47
    Marker Score: 1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.47
    Marker Score: 14749
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.46
    Marker Score: 610
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.45
    Marker Score: 433
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2242
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.45
    Marker Score: 1802
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165847
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3359
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.42
    Marker Score: 1507
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.42
    Marker Score: 1230
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.42
    Marker Score: 6119
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.41
    Marker Score: 1617
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4
    Marker Score: 12096
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.39
    Marker Score: 440
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.39
    Marker Score: 10351
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5462
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.38
    Marker Score: 845
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.35
    Marker Score: 567
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.34
    Marker Score: 332
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.34
    Marker Score: 433
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.33
    Marker Score: 3253
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.33
    Marker Score: 421
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.33
    Marker Score: 388
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 797
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.33
    Marker Score: 730
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.32
    Marker Score: 4550
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20548
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.3
    Marker Score: 1151
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.29
    Marker Score: 754
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5398
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.29
    Marker Score: 1096
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.28
    Marker Score: 750
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.28
    Marker Score: 311
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.28
    Marker Score: 7770
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.27
    Marker Score: 851
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.26
    Marker Score: 467.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.26
    Marker Score: 1186
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.26
    Marker Score: 1428
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.26
    Marker Score: 22350
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.26
    Marker Score: 1156
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.26
    Marker Score: 3009
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.25
    Marker Score: 458

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Other Information

**Key characteristics:** * ANXA4 is a transmembrane protein with a molecular weight of approximately 35 kDa. * It is a member of the annexin family of proteins, which are characterized by their ability to bind to phosphatidylserine molecules. * ANXA4 is expressed in high levels in epithelial cells, where it is thought to play a role in the regulation of epithelial cell differentiation and function. * It is also expressed in a variety of other cell types, including kidney cells, enterocytes, and pancreatic ductal cells. **Pathways and functions:** * ANXA4 is a key regulator of epithelial cell differentiation. It is expressed in high levels in epithelial cells during early development, and it is required for the proper differentiation of these cells into functional epithelial tissues. * It also plays a role in the regulation of apoptosis. ANXA4 is expressed in high levels in cells that are about to undergo apoptosis, and it inhibits apoptosis by binding to phosphatidylserine on the surface of the cell. * In addition to its role in epithelial cell differentiation and apoptosis, ANXA4 is also involved in the regulation of the immune response. It is expressed in high levels in epithelial cells, where it plays a role in the regulation of inflammation. **Clinical significance:** * Mutations in the ANXA4 gene have been linked to a number of human diseases, including colorectal cancer, breast cancer, and lung cancer. * In colorectal cancer, mutations in ANXA4 are often associated with the development of tumors in the colon and rectum. * ANXA4 is a promising target for the treatment of cancer. Antibodies against ANXA4 have been shown to be effective in inhibiting cancer cell growth in vitro and in vivo.

Genular Protein ID: 3662417172

Symbol: ANXA4_HUMAN

Name: 35-beta calcimedin

UniProtKB Accession Codes:

P09525 B4DDF9 Q6LES2 Q96F33 Q9BWK1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 6 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 2 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 2 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2970257

Title: Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family.

PubMed ID: 2970257

PubMed ID: 1346776

Title: Chromosomal mapping of the human annexin IV (ANX4) gene.

PubMed ID: 1346776

DOI: 10.1016/0888-7543(92)90379-7

PubMed ID: 9084877

Title: Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17.

PubMed ID: 9084877

DOI: 10.1248/bpb.20.224

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2975506

Title: Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family.

PubMed ID: 2975506

DOI: 10.1021/bi00417a011

PubMed ID: 2974032

Title: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor.

PubMed ID: 2974032

DOI: 10.1016/s0021-9258(18)37335-6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2254922

Title: Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV.

PubMed ID: 2254922

DOI: 10.1016/s0022-2836(05)80310-9

Sequence Information:

  • Length: 319
  • Mass: 35883
  • Checksum: 3799FE80A93AB215
  • Sequence:
    • MATKGGTVKA ASGFNAMEDA QTLRKAMKGL GTDEDAIISV LAYRNTAQRQ EIRTAYKSTI 
GRDLIDDLKS ELSGNFEQVI VGMMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRTPEE 
IRRISQTYQQ QYGRSLEDDI RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE 
AGEKKWGTDE VKFLTVLCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 
KCMRNKSAYF AEKLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK 
GDTSGDYRKV LLVLCGGDD

Genular Protein ID: 2036103935

Symbol: Q6P452_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P452

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 5 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 299
  • Mass: 33552
  • Checksum: CB81FAA4E951DA56
  • Sequence:
    • MAMATKGGTV KAASGFNAME DAQTLRKAMK GLGTDEDAII SVLAYRNTAQ RQEIRTAYKS 
TIGRDLIDDL KSELSGNFEQ GAGTDEGCLI EILASRTPEE IRRISQTYQQ QYGRSLEDDI 
RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE AGEKKWGTDE VKFLTVLCSR 
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF AEKLYKSMKG 
LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK GDTSGDYRKV LLVLCGGDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.