ANXA4 | ENSG00000196975 | NCBI 307

Details for: ANXA4

Gene ID: 307

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ANXA4

Ensembl ID: ENSG00000196975

Description: annexin A4

Cell Significance Landscape

Display Count:

Associated with

Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Epithelial cell differentiation
(GO:0030855)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nf-kappab binding
(GO:0051059)
Notch signaling pathway
(GO:0007219)
Nuclear membrane
(GO:0031965)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylserine binding
(GO:0001786)
Phospholipase inhibitor activity
(GO:0004859)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signal transduction
(GO:0007165)
Vesicle membrane
(GO:0012506)
Zymogen granule membrane
(GO:0042589)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

intestinal epithelial cell CL0002563

CSI 57.83

rCSI 60.44%

PRS 65.87
lung ciliated cell CL1000271

CSI 48.29

rCSI 55.84%

PRS 58.87
intrahepatic cholangiocyte CL0002538

CSI 47.79

rCSI 100%

PRS 76.4
colon epithelial cell CL0011108

CSI 46.79

rCSI 49.01%

PRS 64.73
ciliated epithelial cell CL0000067

CSI 46.24

rCSI 40.66%

PRS 56.02
extravillous trophoblast CL0008036

CSI 42.24

rCSI 52.25%

PRS 64.92
stem cell CL0000034

CSI 41.02

rCSI 39.55%

PRS 59.48
enterocyte CL0000584

CSI 39.72

rCSI 64.05%

PRS 70.15
intestinal tuft cell CL0019032

CSI 39.72

rCSI 60.7%

PRS 72.3
renal alpha-intercalated cell CL0005011

CSI 38.98

rCSI 52.11%

PRS 76.42
pancreatic ductal cell CL0002079

CSI 38.32

rCSI 74.52%

PRS 71.13
mucous neck cell CL0000651

CSI 32.56

rCSI 46.92%

PRS 77.5
colonocyte CL1000347

CSI 31.65

rCSI 45.37%

PRS 70.62
tuft cell of colon CL0009041

CSI 25.81

rCSI 60.12%

PRS 77.35
pulmonary ionocyte CL0017000

CSI 25.24

rCSI 30.72%

PRS 75.35
pancreatic acinar cell CL0002064

CSI 24.08

rCSI 32%

PRS 74.29
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 23.87

rCSI 61.7%

PRS 63.09
intestine goblet cell CL0019031

CSI 23.07

rCSI 20.48%

PRS 65.79
BEST4+ enteroycte CL4030026

CSI 22.29

rCSI 27.72%

PRS 69.78
foveolar cell of stomach CL0002179

CSI 21.42

rCSI 45.59%

PRS 77.58
syncytiotrophoblast cell CL0000525

CSI 21.17

rCSI 60.99%

PRS 79.31
ionocyte CL0005006

CSI 20.35

rCSI 21.81%

PRS 68.24
renal beta-intercalated cell CL0002201

CSI 20.21

rCSI 48.18%

PRS 68.53
brush cell CL0002204

CSI 20.01

rCSI 39.61%

PRS 81.82
goblet cell CL0000160

CSI 19.6

rCSI 18.52%

PRS 67.17
glandular epithelial cell CL0000150

CSI 19.03

rCSI 50.11%

PRS 84.16
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 18.08

rCSI 24.84%

PRS 85.93
epithelial cell of proximal tubule CL0002306

CSI 16.33

rCSI 39.88%

PRS 61.22
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 16.11

rCSI 57.99%

PRS 47.56
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 15.39

rCSI 35.09%

PRS 63.66
placental villous trophoblast CL2000060

CSI 15.31

rCSI 23.66%

PRS 66.59
melanocyte CL0000148

CSI 14.97

rCSI 11.09%

PRS 60.91
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 14.78

rCSI 20.95%

PRS 64.49
cholangiocyte CL1000488

CSI 14.4

rCSI 86.29%

PRS 73.57
intestinal crypt stem cell of small intestine CL0009017

CSI 14.24

rCSI 38.38%

PRS 74.4
epithelial cell CL0000066

CSI 13.84

rCSI 21.27%

PRS 61.33
hepatocyte CL0000182

CSI 13.71

rCSI 24.53%

PRS 67.56
paneth cell CL0000510

CSI 13.09

rCSI 19.33%

PRS 82.17
M cell of gut CL0000682

CSI 12.96

rCSI 13.77%

PRS 76.41
transit amplifying cell CL0009010

CSI 12.52

rCSI 19.14%

PRS 80.03
sst GABAergic cortical interneuron CL4023017

CSI 12.19

rCSI 15.71%

PRS 50.68
transit amplifying cell of colon CL0009011

CSI 12.13

rCSI 14.25%

PRS 70.1
small intestine goblet cell CL1000495

CSI 11.93

rCSI 26.12%

PRS 75.21
colon goblet cell CL0009039

CSI 10.52

rCSI 25.01%

PRS 75.88
elicited macrophage CL0000861

CSI 10.41

rCSI 9.55%

PRS 77.21
non-classical monocyte CL0000875

CSI 10.4

rCSI 16.67%

PRS 85.64
paneth cell of epithelium of small intestine CL1000343

CSI 10.37

rCSI 29.07%

PRS 78.04
interstitial cell of Cajal CL0002088

CSI 10.37

rCSI 13.2%

PRS 74.08
CD14-positive monocyte CL0001054

CSI 10.35

rCSI 12.89%

PRS 78.73
kidney epithelial cell CL0002518

CSI 10.08

rCSI 19.23%

PRS 85.47
bronchus fibroblast of lung CL2000093

CSI 10.03

rCSI 8.15%

PRS 68.42
transit amplifying cell of small intestine CL0009012

CSI 9.83

rCSI 43.14%

PRS 80.71
Schwann cell CL0002573

CSI 9.52

rCSI 27.05%

PRS 65.7
CD14-low, CD16-positive monocyte CL0002396

CSI 8.88

rCSI 6.84%

PRS 69.48
skin fibroblast CL0002620

CSI 8.5

rCSI 7.33%

PRS 72.01
adipocyte CL0000136

CSI 8.32

rCSI 10.68%

PRS 59.88
ciliated cell CL0000064

CSI 8.3

rCSI 13.46%

PRS 64.02
choroid plexus epithelial cell CL0000706

CSI 8.08

rCSI 13.23%

PRS 57.17
kidney interstitial alternatively activated macrophage CL1000695

CSI 8.05

rCSI 20.98%

PRS 68.31
keratocyte CL0002363

CSI 8.01

rCSI 19.26%

PRS 74.54
vascular leptomeningeal cell CL4023051

CSI 7.65

rCSI 13.41%

PRS 60.62
lung pericyte CL0009089

CSI 7.13

rCSI 18.83%

PRS 76.54
Mueller cell CL0000636

CSI 7.07

rCSI 16.14%

PRS 59.61
respiratory hillock cell CL4030023

CSI 6.81

rCSI 12.14%

PRS 80.38
myofibroblast cell CL0000186

CSI 6.71

rCSI 9.29%

PRS 67.81
secretory cell CL0000151

CSI 6.66

rCSI 6.95%

PRS 67.9
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 6.45

rCSI 4.3%

PRS 85.1
hematopoietic precursor cell CL0008001

CSI 6.44

rCSI 6.63%

PRS 82.95
keratinocyte CL0000312

CSI 6.23

rCSI 5.23%

PRS 71.63
Hofbauer cell CL3000001

CSI 6.03

rCSI 11.39%

PRS 78.24
immature B cell CL0000816

CSI 5.96

rCSI 4.43%

PRS 80.87
enterocyte of epithelium of large intestine CL0002071

CSI 5.95

rCSI 31.23%

PRS 76.23
retinal rod cell CL0000604

CSI 5.9

rCSI 10.4%

PRS 64.44
double negative thymocyte CL0002489

CSI 5.9

rCSI 4.1%

PRS 79.34
blood vessel endothelial cell CL0000071

CSI 5.89

rCSI 12.21%

PRS 65.1
fibroblast of lung CL0002553

CSI 5.8

rCSI 5.39%

PRS 68.73
pro-B cell CL0000826

CSI 5.67

rCSI 4.69%

PRS 70.43
near-projecting glutamatergic cortical neuron CL4023012

CSI 5.54

rCSI 20.93%

PRS 49.93
mature B cell CL0000785

CSI 5.52

rCSI 4.8%

PRS 78.56
myeloid dendritic cell CL0000782

CSI 5.29

rCSI 7.66%

PRS 83.24
pulmonary alveolar type 2 cell CL0002063

CSI 5.23

rCSI 8.11%

PRS 74.66
type B pancreatic cell CL0000169

CSI 5.18

rCSI 11.47%

PRS 66.47
class switched memory B cell CL0000972

CSI 5.09

rCSI 3.8%

PRS 83.31
fallopian tube secretory epithelial cell CL4030006

CSI 5.05

rCSI 4.86%

PRS 67.85
cardiac muscle cell CL0000746

CSI 5.02

rCSI 7.21%

PRS 57.64
alveolar type 1 fibroblast cell CL4028004

CSI 4.99

rCSI 5.47%

PRS 71.54
stratified epithelial cell CL0000079

CSI 4.98

rCSI 30.74%

PRS 82.76
brush cell of tracheobronchial tree CL0002075

CSI 4.93

rCSI 14.63%

PRS 77.96
epithelial cell of lower respiratory tract CL0002632

CSI 4.93

rCSI 3.82%

PRS 71.09
Kupffer cell CL0000091

CSI 4.9

rCSI 11.21%

PRS 68.58
enteroendocrine cell CL0000164

CSI 4.8

rCSI 6.56%

PRS 68.97
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.77

rCSI 3.63%

PRS 81.02
retinal pigment epithelial cell CL0002586

CSI 4.77

rCSI 9.47%

PRS 64.9
erythrocyte CL0000232

CSI 4.65

rCSI 10.55%

PRS 70.52
perivascular cell CL4033054

CSI 4.64

rCSI 6.34%

PRS 73.79
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 4.54

rCSI 14.18%

PRS 53.6
plasmacytoid dendritic cell, human CL0001058

CSI 4.53

rCSI 3.16%

PRS 71.01
lung macrophage CL1001603

CSI 4.52

rCSI 10.1%

PRS 75.8
hepatic stellate cell CL0000632

CSI 4.48

rCSI 16.8%

PRS 59.99
blood vessel smooth muscle cell CL0019018

CSI 4.46

rCSI 36.28%

PRS 61.59

kidney loop of Henle epithelial cell CL1000909

CSI 0.3

rCSI 5.6%

PRS 90.8%
direct pathway medium spiny neuron CL4023026

CSI 0.3

rCSI 6.4%

PRS 48.5%
indirect pathway medium spiny neuron CL4023029

CSI 0.4

rCSI 9.2%

PRS 49.2%
mesenchymal cell CL0008019

CSI 0.4

rCSI 1.1%

PRS 61.8%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.4%

PRS 64.4%
enteroendocrine cell of colon CL0009042

CSI 0.5

rCSI 2.5%

PRS 82.4%
megakaryocyte CL0000556

CSI 0.7

rCSI 2.8%

PRS 78.1%
renal intercalated cell CL0005010

CSI 0.7

rCSI 6.0%

PRS 94.7%
retinal cone cell CL0000573

CSI 0.8

rCSI 1.2%

PRS 57.5%
epicardial adipocyte CL1000309

CSI 0.8

rCSI 2.5%

PRS 67.5%
lung goblet cell CL1000143

CSI 0.8

rCSI 9.2%

PRS 84.9%
basal cell of epithelium of trachea CL1000348

CSI 0.8

rCSI 5.9%

PRS 79.4%
squamous epithelial cell CL0000076

CSI 0.9

rCSI 2.1%

PRS 70.7%
respiratory epithelial cell CL0002368

CSI 0.9

rCSI 5.5%

PRS 90.6%
regular ventricular cardiac myocyte CL0002131

CSI 0.9

rCSI 5.7%

PRS 59.6%
promonocyte CL0000559

CSI 1.0

rCSI 1.7%

PRS 76.1%
tracheobronchial serous cell CL0019001

CSI 1.0

rCSI 4.3%

PRS 79.0%
basophil CL0000767

CSI 1.0

rCSI 2.2%

PRS 83.6%
colon macrophage CL0009038

CSI 1.1

rCSI 5.0%

PRS 84.8%
pancreatic epsilon cell CL0005019

CSI 1.1

rCSI 5.3%

PRS 82.2%
pancreatic PP cell CL0002275

CSI 1.2

rCSI 4.6%

PRS 78.7%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.2

rCSI 5.8%

PRS 80.5%
mucus secreting cell CL0000319

CSI 1.2

rCSI 1.8%

PRS 78.4%
pancreatic stellate cell CL0002410

CSI 1.2

rCSI 6.8%

PRS 75.4%
mammary gland epithelial cell CL0002327

CSI 1.2

rCSI 4.3%

PRS 79.1%
peptic cell CL0000155

CSI 1.3

rCSI 12.7%

PRS 83.5%
bronchial goblet cell CL1000312

CSI 1.3

rCSI 5.3%

PRS 81.4%
luminal epithelial cell of mammary gland CL0002326

CSI 1.5

rCSI 2.6%

PRS 81.8%
macroglial cell CL0000126

CSI 1.5

rCSI 3.8%

PRS 66.5%
intermediate monocyte CL0002393

CSI 1.5

rCSI 2.2%

PRS 73.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.6

rCSI 2.7%

PRS 49.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.6

rCSI 16.8%

PRS 65.7%
respiratory goblet cell CL0002370

CSI 1.7

rCSI 18.5%

PRS 80.5%
common myeloid progenitor CL0000049

CSI 1.7

rCSI 1.4%

PRS 69.9%
Bergmann glial cell CL0000644

CSI 1.8

rCSI 2.4%

PRS 60.7%
promyelocyte CL0000836

CSI 1.8

rCSI 2.5%

PRS 76.3%
tracheal goblet cell CL1000329

CSI 1.8

rCSI 3.9%

PRS 79.2%
periportal region hepatocyte CL0019026

CSI 1.9

rCSI 7.4%

PRS 71.1%
enteroendocrine cell of small intestine CL0009006

CSI 1.9

rCSI 4.2%

PRS 79.3%
L6b glutamatergic cortical neuron CL4023038

CSI 1.9

rCSI 6.0%

PRS 51.1%
deuterosomal cell CL4033044

CSI 2.0

rCSI 6.7%

PRS 69.9%
lung secretory cell CL1000272

CSI 2.0

rCSI 5.0%

PRS 66.8%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.2

rCSI 13.0%

PRS 50.5%
hematopoietic multipotent progenitor cell CL0000837

CSI 2.3

rCSI 5.4%

PRS 84.3%
tracheobronchial smooth muscle cell CL0019019

CSI 2.3

rCSI 4.0%

PRS 75.7%
cerebellar granule cell CL0001031

CSI 2.3

rCSI 3.4%

PRS 61.3%
retinal ganglion cell CL0000740

CSI 2.3

rCSI 5.1%

PRS 54.0%
IgA plasma cell CL0000987

CSI 2.5

rCSI 2.6%

PRS 80.2%
renal principal cell CL0005009

CSI 2.5

rCSI 6.5%

PRS 71.1%
chondrocyte CL0000138

CSI 2.5

rCSI 4.0%

PRS 60.8%
kidney collecting duct intercalated cell CL1001432

CSI 2.5

rCSI 18.0%

PRS 67.8%
granulocyte monocyte progenitor cell CL0000557

CSI 2.5

rCSI 2.2%

PRS 72.8%
mesodermal cell CL0000222

CSI 2.5

rCSI 3.1%

PRS 66.2%
astrocyte of the cerebral cortex CL0002605

CSI 2.6

rCSI 5.7%

PRS 50.0%
granulocyte CL0000094

CSI 2.6

rCSI 3.9%

PRS 77.2%
unswitched memory B cell CL0000970

CSI 2.6

rCSI 2.2%

PRS 83.7%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.6

rCSI 22.5%

PRS 64.2%
nasal mucosa goblet cell CL0002480

CSI 2.6

rCSI 3.0%

PRS 74.7%
regular atrial cardiac myocyte CL0002129

CSI 2.7

rCSI 8.6%

PRS 65.8%
acinar cell CL0000622

CSI 2.7

rCSI 3.9%

PRS 79.3%
adventitial cell CL0002503

CSI 2.7

rCSI 6.4%

PRS 75.5%
transitional stage B cell CL0000818

CSI 2.7

rCSI 8.8%

PRS 89.3%
multi-ciliated epithelial cell CL0005012

CSI 2.7

rCSI 2.7%

PRS 61.6%
centrilobular region hepatocyte CL0019029

CSI 2.7

rCSI 7.1%

PRS 70.0%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 2.8

rCSI 4.9%

PRS 48.5%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.8

rCSI 2.5%

PRS 65.2%
lung neuroendocrine cell CL1000223

CSI 2.8

rCSI 4.2%

PRS 73.1%
type EC enteroendocrine cell CL0000577

CSI 2.8

rCSI 10.0%

PRS 75.1%
dendritic cell, human CL0001056

CSI 2.9

rCSI 4.4%

PRS 77.4%
activated type II NK T cell CL0000931

CSI 2.9

rCSI 3.3%

PRS 83.7%
respiratory suprabasal cell CL4033048

CSI 2.9

rCSI 3.7%

PRS 72.5%
VIP GABAergic cortical interneuron CL4023016

CSI 2.9

rCSI 3.5%

PRS 49.2%
myeloid leukocyte CL0000766

CSI 2.9

rCSI 2.7%

PRS 69.8%
pulmonary alveolar type 1 cell CL0002062

CSI 2.9

rCSI 16.9%

PRS 66.1%
type L enteroendocrine cell CL0002279

CSI 2.9

rCSI 5.5%

PRS 80.5%
epithelial cell of lung CL0000082

CSI 3.0

rCSI 2.5%

PRS 67.8%
glial cell CL0000125

CSI 3.0

rCSI 11.3%

PRS 58.5%
lung interstitial macrophage CL4033043

CSI 3.0

rCSI 6.7%

PRS 83.7%
interneuron CL0000099

CSI 3.0

rCSI 6.0%

PRS 57.3%
pvalb GABAergic cortical interneuron CL4023018

CSI 3.0

rCSI 3.8%

PRS 47.4%
club cell CL0000158

CSI 3.0

rCSI 4.5%

PRS 63.1%
renal interstitial pericyte CL1001318

CSI 3.0

rCSI 8.4%

PRS 63.3%
pancreatic D cell CL0000173

CSI 3.1

rCSI 3.0%

PRS 70.6%
kidney connecting tubule epithelial cell CL1000768

CSI 3.2

rCSI 8.1%

PRS 57.6%
microcirculation associated smooth muscle cell CL0008035

CSI 3.3

rCSI 9.5%

PRS 68.8%
alveolar adventitial fibroblast CL4028006

CSI 3.3

rCSI 5.2%

PRS 70.4%
podocyte CL0000653

CSI 3.4

rCSI 15.3%

PRS 68.2%
retinal blood vessel endothelial cell CL0002585

CSI 3.4

rCSI 5.5%

PRS 72.3%
cardiac endothelial cell CL0010008

CSI 3.5

rCSI 14.0%

PRS 67.2%
conjunctival epithelial cell CL1000432

CSI 3.5

rCSI 5.4%

PRS 68.8%
respiratory basal cell CL0002633

CSI 3.6

rCSI 3.7%

PRS 73.8%
mononuclear phagocyte CL0000113

CSI 3.6

rCSI 7.9%

PRS 72.2%
basal cell CL0000646

CSI 3.6

rCSI 4.8%

PRS 68.0%
inflammatory macrophage CL0000863

CSI 3.7

rCSI 6.3%

PRS 88.2%
duct epithelial cell CL0000068

CSI 3.7

rCSI 5.5%

PRS 72.9%
endocardial cell CL0002350

CSI 3.7

rCSI 17.9%

PRS 66.1%
hematopoietic stem cell CL0000037

CSI 3.8

rCSI 2.5%

PRS 70.9%
cardiac neuron CL0010022

CSI 3.8

rCSI 12.1%

PRS 65.4%
alternatively activated macrophage CL0000890

CSI 3.8

rCSI 4.8%

PRS 79.5%
enterocyte of epithelium of small intestine CL1000334

CSI 3.8

rCSI 59.0%

PRS 81.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ANXA4](/details-gene/307) (Annexin A4) is a protein-coding gene located on chromosome 2p13.3. It belongs to the annexin family of calcium-dependent phospholipid-binding proteins, which are involved in a wide range of cellular processes including signal transduction, membrane trafficking, and regulation of apoptosis. Functionally, [ANXA4](/details-gene/307) is known to bind to phospholipids like phosphatidylserine in a calcium-dependent manner and exhibits phospholipase inhibitor activity. **Overall**, expression data reveals that [ANXA4](/details-gene/307) is a prominent marker of various epithelial cell types, particularly those involved in secretory and barrier functions. Its high significance in cells such as [intestinal epithelial cell](/details-cell/CL0002563), [lung ciliated cell](/details-cell/CL1000271), and [intrahepatic cholangiocyte](/details-cell/CL0002538) underscores its fundamental role in the maintenance and function of epithelial tissues throughout the body. ## Cellular Roles and Expression Landscape The expression profile of [ANXA4](/details-gene/307) strongly indicates a specialized role within epithelial lineages. **Overall**, the gene shows its highest significance in a broad array of epithelial cells lining various organs. It is a top marker for [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 57.83), [colon epithelial cell](/details-cell/CL0011108) (CSI: 46.79), and their subtypes like [enterocyte](/details-cell/CL0000584) and [colonocyte](/details-cell/CL1000347). This pattern extends to the respiratory system, with high significance in [lung ciliated cell](/details-cell/CL1000271) (CSI: 48.29) and [pulmonary ionocyte](/details-cell/CL0017000) (CSI: 25.24), and secretory tissues like the liver ([intrahepatic cholangiocyte](/details-cell/CL0002538), CSI: 47.79) and pancreas ([pancreatic ductal cell](/details-cell/CL0002079), CSI: 38.32). This consistent, high-level expression across diverse epithelial populations suggests that [ANXA4](/details-gene/307) is a core component of the molecular machinery governing fundamental epithelial functions, such as maintaining cell structure, regulating ion transport, and participating in mucosal defense. Its presence in specialized cells like [intestinal tuft cell](/details-cell/CL0019032) and [tuft cell of colon](/details-cell/CL0009041) also points towards a potential role in chemosensation and mucosal immune responses. The gene's association with [stem cell](/details-cell/CL0000034) (CSI: 41.02) may indicate its involvement in epithelial tissue renewal and differentiation. ## Pathways and Molecular Function The molecular functions of [ANXA4](/details-gene/307) are centered on its calcium-dependent interactions with cellular membranes and proteins. Gene Ontology annotations highlight its core activities as [calcium ion binding](/details-go/GO:0005509), [calcium-dependent phospholipid binding](/details-go/GO:0005544), and specifically [phosphatidylserine binding](/details-go/GO:0001786). These functions are consistent with its localization to the [plasma membrane](/details-go/GO:0005886), [cell surface](/details-go/GO:0009986), and various vesicle membranes, where it can modulate membrane organization and trafficking. Biologically, [ANXA4](/details-gene/307) is implicated in several key processes that align with its epithelial expression pattern. Its role in [epithelial cell differentiation](/details-go/GO:0030855) is consistent with its high expression in mature epithelial populations. Furthermore, it functions as a [negative regulator of the apoptotic process](/details-go/GO:0043066), which is critical for maintaining the integrity of epithelial barriers. [ANXA4](/details-gene/307) also participates in intracellular signaling by negatively regulating [NF-kappaB transcription factor activity](/details-go/GO:0032088) and [interleukin-8 production](/details-go/GO:0032717), suggesting an anti-inflammatory role within epithelial tissues. This combination of functions positions [ANXA4](/details-gene/307) as a multifunctional protein that links membrane dynamics to cell fate decisions and inflammatory signaling in epithelial contexts. ## Research Directions The specific and high-level expression of [ANXA4](/details-gene/307) in a multitude of epithelial tissues, combined with its anti-apoptotic and anti-inflammatory functions, suggests it is a critical homeostatic factor. Its dysregulation is likely to be involved in pathologies characterized by epithelial dysfunction, such as inflammatory bowel disease, chronic obstructive pulmonary disease, or various carcinomas. ### Proposed Hypotheses 1. **Hypothesis 1:** Given its role in negatively regulating apoptosis and NF-κB activity, downregulation of [ANXA4](/details-gene/307) in [intestinal epithelial cell](/details-cell/CL0002563) sensitizes the gut lining to inflammatory stimuli, leading to compromised barrier function and increased cell death, thereby contributing to the pathogenesis of inflammatory bowel disease. 2. **Hypothesis 2:** In [lung ciliated cell](/details-cell/CL1000271), the calcium-dependent membrane-binding activity of [ANXA4](/details-gene/307) is essential for the structural integrity and dynamic movement of cilia. Loss-of-function mutations or reduced expression could impair mucociliary clearance, predisposing individuals to chronic respiratory infections. 3. **Hypothesis 3:** [ANXA4](/details-gene/307) acts as a tumor suppressor in the early stages of colon cancer by promoting [epithelial cell differentiation](/details-go/GO:0030855) and inhibiting pro-survival NF-κB signals. Epigenetic silencing or mutational inactivation of [ANXA4](/details-gene/307) may be a key event in the transformation of [colon epithelial cell](/details-cell/CL0011108). ### Key Experiment To test **Hypothesis 1**, one could utilize 3D intestinal organoids derived from human pluripotent stem cells. CRISPR-Cas9 would be used to generate [ANXA4](/details-gene/307) knockout (KO) organoids alongside isogenic wild-type (WT) controls. These organoids would then be challenged with a pro-inflammatory cytokine cocktail (e.g., TNF-α and IFN-γ). The functional consequences would be assessed by: (i) measuring barrier permeability using a FITC-dextran assay on organoid-derived monolayers, (ii) quantifying apoptosis via cleaved caspase-3 immunostaining and TUNEL assays, and (iii) analyzing the activation of the NF-κB pathway by measuring the phosphorylation of p65 and expression of downstream target genes (e.g., IL6, IL8) via western blot and RT-qPCR. A significant increase in permeability, apoptosis, and NF-κB signaling in KO organoids upon inflammatory challenge would strongly support the hypothesis. ### Therapeutic Potential The role of [ANXA4](/details-gene/307) in disease is context-dependent. Its anti-apoptotic and anti-inflammatory properties suggest it could be a therapeutic agent, rather than a target for inhibition, in diseases characterized by epithelial damage and inflammation, such as ulcerative colitis. A therapeutic strategy could involve the localized delivery of recombinant [ANXA4](/details-gene/307) protein or a gene therapy vector to restore its protective function in the gut mucosa. Conversely, in certain cancers where [ANXA4](/details-gene/307) expression is paradoxically elevated and linked to chemoresistance (due to its anti-apoptotic function), it could represent a target for inhibition. However, its widespread expression in healthy epithelial tissues would make systemic inhibition challenging, necessitating highly targeted delivery systems to avoid significant off-target toxicity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

35-beta calcimedin
Q6P452_HUMAN

Genular Protein ID: 3662417172

Symbol: ANXA4_HUMAN

Name: 35-beta calcimedin

UniProtKB Accession Codes:

P09525 B4DDF9 Q6LES2 Q96F33 Q9BWK1

Database IDs:

Citations:

PubMed ID: 2970257

Title: Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family.

PubMed ID: 2970257

PubMed ID: 1346776

Title: Chromosomal mapping of the human annexin IV (ANX4) gene.

PubMed ID: 1346776

DOI: 10.1016/0888-7543(92)90379-7

PubMed ID: 9084877

Title: Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17.

PubMed ID: 9084877

DOI: 10.1248/bpb.20.224

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2975506

Title: Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family.

PubMed ID: 2975506

DOI: 10.1021/bi00417a011

PubMed ID: 2974032

Title: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor.

PubMed ID: 2974032

DOI: 10.1016/s0021-9258(18)37335-6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2254922

Title: Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV.

PubMed ID: 2254922

DOI: 10.1016/s0022-2836(05)80310-9

Sequence Information:

Length: 319
Mass: 35883
Checksum: 3799FE80A93AB215
Sequence:

MATKGGTVKA ASGFNAMEDA QTLRKAMKGL GTDEDAIISV LAYRNTAQRQ EIRTAYKSTI 
GRDLIDDLKS ELSGNFEQVI VGMMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRTPEE 
IRRISQTYQQ QYGRSLEDDI RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE 
AGEKKWGTDE VKFLTVLCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 
KCMRNKSAYF AEKLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK 
GDTSGDYRKV LLVLCGGDD

Genular Protein ID: 2036103935

Symbol: Q6P452_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P452

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 299
Mass: 33552
Checksum: CB81FAA4E951DA56
Sequence:

MAMATKGGTV KAASGFNAME DAQTLRKAMK GLGTDEDAII SVLAYRNTAQ RQEIRTAYKS 
TIGRDLIDDL KSELSGNFEQ GAGTDEGCLI EILASRTPEE IRRISQTYQQ QYGRSLEDDI 
RSDTSFMFQR VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE AGEKKWGTDE VKFLTVLCSR 
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF AEKLYKSMKG 
LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK GDTSGDYRKV LLVLCGGDD

Details for: ANXA4

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. PubMed ID: 2970257

Chromosomal mapping of the human annexin IV (ANX4) gene. PubMed ID: 1346776

Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. PubMed ID: 9084877

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. PubMed ID: 2975506

Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. PubMed ID: 2974032

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV. PubMed ID: 2254922

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PubMed ID: 2970257

PubMed ID: 1346776

PubMed ID: 9084877

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 2975506

PubMed ID: 2974032

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 24275569

PubMed ID: 2254922

PubMed ID: 11237011

PubMed ID: 15489334

PubMed ID: 15496913

PubMed ID: 15815621

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 24275569