Details for: ANXA5

Gene ID: 308

Symbol: ANXA5

Ensembl ID: ENSG00000164111

Description: annexin A5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 595.0038
    Cell Significance Index: -92.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 345.0514
    Cell Significance Index: -87.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 230.3691
    Cell Significance Index: -94.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 201.7061
    Cell Significance Index: -95.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.4545
    Cell Significance Index: -91.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 142.6331
    Cell Significance Index: -95.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 88.1389
    Cell Significance Index: -84.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.9581
    Cell Significance Index: -92.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.5021
    Cell Significance Index: -81.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.2462
    Cell Significance Index: -70.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.6097
    Cell Significance Index: -93.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.1291
    Cell Significance Index: -35.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.1702
    Cell Significance Index: 320.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 9.6407
    Cell Significance Index: 257.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.7869
    Cell Significance Index: 125.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.1969
    Cell Significance Index: 576.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.7453
    Cell Significance Index: 86.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.5831
    Cell Significance Index: 168.4000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.4584
    Cell Significance Index: 16.8200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.2465
    Cell Significance Index: 14.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0351
    Cell Significance Index: 1657.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 3.0263
    Cell Significance Index: 345.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9227
    Cell Significance Index: 136.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6991
    Cell Significance Index: 140.5900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.3594
    Cell Significance Index: 14.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2826
    Cell Significance Index: 170.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.2523
    Cell Significance Index: 28.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1601
    Cell Significance Index: 56.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6394
    Cell Significance Index: 210.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5412
    Cell Significance Index: 41.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5291
    Cell Significance Index: 188.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4039
    Cell Significance Index: 41.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0458
    Cell Significance Index: 18.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9508
    Cell Significance Index: 122.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9163
    Cell Significance Index: 10.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8521
    Cell Significance Index: 376.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6716
    Cell Significance Index: 133.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6677
    Cell Significance Index: 120.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5344
    Cell Significance Index: 10.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4950
    Cell Significance Index: 58.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4457
    Cell Significance Index: 9.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4209
    Cell Significance Index: 29.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3478
    Cell Significance Index: 314.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2713
    Cell Significance Index: 17.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2184
    Cell Significance Index: 37.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1558
    Cell Significance Index: 107.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1374
    Cell Significance Index: 104.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0989
    Cell Significance Index: 72.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0943
    Cell Significance Index: 0.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0842
    Cell Significance Index: 8.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0829
    Cell Significance Index: 156.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0771
    Cell Significance Index: 1.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0732
    Cell Significance Index: 46.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0288
    Cell Significance Index: 2.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0122
    Cell Significance Index: 2.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0120
    Cell Significance Index: 2.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0400
    Cell Significance Index: -29.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0424
    Cell Significance Index: -78.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0465
    Cell Significance Index: -29.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0518
    Cell Significance Index: -79.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0718
    Cell Significance Index: -97.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1015
    Cell Significance Index: -46.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1088
    Cell Significance Index: -61.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1534
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1878
    Cell Significance Index: -39.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1991
    Cell Significance Index: -22.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2303
    Cell Significance Index: -82.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2483
    Cell Significance Index: -11.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2791
    Cell Significance Index: -40.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2854
    Cell Significance Index: -82.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2899
    Cell Significance Index: -14.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3503
    Cell Significance Index: -9.3700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4108
    Cell Significance Index: -2.9500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.4114
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5251
    Cell Significance Index: -41.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5912
    Cell Significance Index: -68.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7016
    Cell Significance Index: -53.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8077
    Cell Significance Index: -17.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8110
    Cell Significance Index: -84.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8506
    Cell Significance Index: -5.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8532
    Cell Significance Index: -29.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8988
    Cell Significance Index: -53.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9176
    Cell Significance Index: -29.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9652
    Cell Significance Index: -20.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0047
    Cell Significance Index: -56.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0069
    Cell Significance Index: -28.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0432
    Cell Significance Index: -64.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0991
    Cell Significance Index: -29.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1048
    Cell Significance Index: -69.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1723
    Cell Significance Index: -60.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3598
    Cell Significance Index: -28.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3681
    Cell Significance Index: -34.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3732
    Cell Significance Index: -11.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.4543
    Cell Significance Index: -22.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4729
    Cell Significance Index: -99.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.4925
    Cell Significance Index: -61.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5266
    Cell Significance Index: -93.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5795
    Cell Significance Index: -21.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.7254
    Cell Significance Index: -90.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.9648
    Cell Significance Index: -21.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANXA5 is a small, acidic protein that is approximately 36 kDa in size. It is characterized by its high affinity for phospholipids, particularly phosphatidylserine, and its ability to bind to calcium ions. This binding is essential for its function, as it allows ANXA5 to regulate the activity of phospholipases and modulate the phospholipid composition of cell membranes. ANXA5 is also known for its ability to bind to proteins, including annexins, phospholipids, and proteins involved in cell signaling. **Pathways and Functions** ANXA5 is involved in numerous biological pathways, including: 1. **Apoptosis regulation**: ANXA5 has been shown to inhibit apoptosis by binding to phosphatidylserine and preventing the activation of caspases. 2. **Coagulation regulation**: ANXA5 inhibits the coagulation cascade by binding to phospholipids and preventing the activation of coagulation factors. 3. **Cell signaling**: ANXA5 modulates cell signaling by binding to proteins involved in signaling pathways, including the PI3K/Akt pathway. 4. **Phospholipid metabolism**: ANXA5 regulates phospholipid metabolism by binding to phospholipases and modulating their activity. ANXA5's functions can be broadly categorized into three main areas: 1. **Inhibition of apoptosis**: ANXA5's ability to bind to phosphatidylserine and prevent caspase activation makes it an important regulator of apoptosis. 2. **Inhibition of coagulation**: ANXA5's binding to phospholipids and inhibition of coagulation factors makes it an important regulator of the coagulation cascade. 3. **Modulation of cell signaling**: ANXA5's ability to bind to proteins involved in signaling pathways makes it an important regulator of cell signaling. **Clinical Significance** ANXA5 has been implicated in various diseases, including: 1. **Thrombosis**: ANXA5's inhibition of coagulation makes it an important regulator of thrombosis. 2. **Apoptosis-related disorders**: ANXA5's role in regulating apoptosis makes it an important regulator of apoptosis-related disorders, such as cancer and neurodegenerative diseases. 3. **Inflammatory disorders**: ANXA5's role in regulating inflammation makes it an important regulator of inflammatory disorders, such as atherosclerosis and autoimmune diseases. In addition to its role in disease, ANXA5 has also been implicated in various clinical applications, including: 1. **Thromboprophylaxis**: ANXA5's inhibition of coagulation makes it a potential target for thromboprophylaxis. 2. **Cancer therapy**: ANXA5's role in regulating apoptosis makes it a potential target for cancer therapy. 3. **Inflammation modulation**: ANXA5's role in regulating inflammation makes it a potential target for inflammation modulation. In conclusion, ANXA5 is a multifunctional protein that plays a crucial role in various biological processes, including apoptosis regulation, coagulation regulation, and cell signaling. Its clinical significance is vast, and it has been implicated in various diseases and clinical applications. Further research is needed to fully understand the functions and clinical significance of ANXA5.

Genular Protein ID: 522571898

Symbol: ANXA5_HUMAN

Name: Annexin A5

UniProtKB Accession Codes:

P08758 D3DNW7 Q6FHB3 Q6FI16 Q8WV69 Q9UDH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 36 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2964863

Title: Primary structure of human placental anticoagulant protein.

PubMed ID: 2964863

DOI: 10.1021/bi00399a011

PubMed ID: 2963810

Title: Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein.

PubMed ID: 2963810

DOI: 10.1093/oxfordjournals.jbchem.a122165

PubMed ID: 2455636

Title: Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein.

PubMed ID: 2455636

DOI: 10.1111/j.1432-1033.1988.tb14139.x

PubMed ID: 2967291

Title: Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.

PubMed ID: 2967291

DOI: 10.1016/s0021-9258(18)68438-8

PubMed ID: 2968983

Title: Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

PubMed ID: 2968983

DOI: 10.1016/s0021-9258(18)38041-4

PubMed ID: 2967495

Title: Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family.

PubMed ID: 2967495

DOI: 10.1073/pnas.85.11.3708

PubMed ID: 7958998

Title: The gene encoding human annexin V has a TATA-less promoter with a high G+C content.

PubMed ID: 7958998

DOI: 10.1016/0378-1119(94)90157-0

PubMed ID: 8034319

Title: Organization of the human annexin V (ANX5) gene.

PubMed ID: 8034319

DOI: 10.1006/geno.1994.1201

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2532007

Title: A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation.

PubMed ID: 2532007

DOI: 10.1042/bj2630929

PubMed ID: 8249278

Title: Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein.

PubMed ID: 8249278

DOI: 10.1006/viro.1993.1628

PubMed ID: 2957692

Title: Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein.

PubMed ID: 2957692

DOI: 10.1073/pnas.84.17.6078

PubMed ID: 2974032

Title: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor.

PubMed ID: 2974032

DOI: 10.1016/s0021-9258(18)37335-6

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 17339269

Title: A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.

PubMed ID: 17339269

DOI: 10.1093/hmg/ddm017

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 2147412

Title: The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.

PubMed ID: 2147412

DOI: 10.1002/j.1460-2075.1990.tb07605.x

PubMed ID: 2148156

Title: The calcium binding sites in human annexin V by crystal structure analysis at 2.0-A resolution. Implications for membrane binding and calcium channel activity.

PubMed ID: 2148156

DOI: 10.1016/0014-5793(90)81428-q

PubMed ID: 1311770

Title: Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.

PubMed ID: 1311770

DOI: 10.1016/0022-2836(92)90984-r

PubMed ID: 9398511

Title: Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor.

PubMed ID: 9398511

DOI: 10.1006/jmbi.1997.1375

PubMed ID: 9435213

Title: Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V.

PubMed ID: 9435213

DOI: 10.1073/pnas.95.2.455

Sequence Information:

  • Length: 320
  • Mass: 35937
  • Checksum: 45E14E3964BA4D1A
  • Sequence:
    • MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL 
FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE 
ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF 
QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV 
VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI 
KGDTSGDYKK ALLLLCGEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.