Details for: ANXA5

Gene ID: 308

Symbol: ANXA5

Ensembl ID: ENSG00000164111

Description: annexin A5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.59
    Marker Score: 156275
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.91
    Marker Score: 4177
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.88
    Marker Score: 3308
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.63
    Marker Score: 203206
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.46
    Marker Score: 4173
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.42
    Marker Score: 3917
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.32
    Marker Score: 1380.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.19
    Marker Score: 4910
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.15
    Marker Score: 6145
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.15
    Marker Score: 15464
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.03
    Marker Score: 35262
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.02
    Marker Score: 4158
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.99
    Marker Score: 1707
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.94
    Marker Score: 7476
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.91
    Marker Score: 5473
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.91
    Marker Score: 7613
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.89
    Marker Score: 2886
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.88
    Marker Score: 99918
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.88
    Marker Score: 7036
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.88
    Marker Score: 73730
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.84
    Marker Score: 18496
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.81
    Marker Score: 7001
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.81
    Marker Score: 3468
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.78
    Marker Score: 6712
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.77
    Marker Score: 11935.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.75
    Marker Score: 7479
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7
    Marker Score: 30393
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.69
    Marker Score: 3901
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.65
    Marker Score: 2073
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.63
    Marker Score: 34710
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.62
    Marker Score: 1181
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.62
    Marker Score: 1092
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.61
    Marker Score: 835
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.6
    Marker Score: 1851
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6
    Marker Score: 5917
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.55
    Marker Score: 635.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.53
    Marker Score: 635.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.53
    Marker Score: 25465.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.53
    Marker Score: 6771
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.51
    Marker Score: 2429
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.51
    Marker Score: 6508
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.49
    Marker Score: 21893
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.49
    Marker Score: 2525
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.48
    Marker Score: 15042.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.47
    Marker Score: 9512
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.44
    Marker Score: 4316
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.43
    Marker Score: 780
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.42
    Marker Score: 24005
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.42
    Marker Score: 1086
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.42
    Marker Score: 1244
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.42
    Marker Score: 986.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.38
    Marker Score: 1392
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.38
    Marker Score: 869.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.38
    Marker Score: 2869
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.38
    Marker Score: 15496
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.37
    Marker Score: 1557
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.36
    Marker Score: 3793
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.32
    Marker Score: 3843
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.31
    Marker Score: 17194.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.3
    Marker Score: 2698
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.29
    Marker Score: 9014
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.29
    Marker Score: 3748
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.26
    Marker Score: 5122
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.25
    Marker Score: 5682
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.24
    Marker Score: 4482
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.24
    Marker Score: 1416
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.24
    Marker Score: 1403
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.23
    Marker Score: 793
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.23
    Marker Score: 2905
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.22
    Marker Score: 862
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.21
    Marker Score: 1219
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.21
    Marker Score: 1585
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.2
    Marker Score: 698
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.19
    Marker Score: 1021
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.18
    Marker Score: 1941
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.17
    Marker Score: 615
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.16
    Marker Score: 497
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.16
    Marker Score: 2058
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.16
    Marker Score: 533
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.16
    Marker Score: 1857
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.16
    Marker Score: 2989
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.16
    Marker Score: 1255
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.15
    Marker Score: 7637.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.14
    Marker Score: 18610
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.13
    Marker Score: 3389
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.13
    Marker Score: 1905
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.12
    Marker Score: 1007
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.12
    Marker Score: 601
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.11
    Marker Score: 908
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.1
    Marker Score: 1399
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.07
    Marker Score: 10866
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.07
    Marker Score: 2147
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.06
    Marker Score: 13188
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.06
    Marker Score: 491.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.06
    Marker Score: 8544
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.05
    Marker Score: 592
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.03
    Marker Score: 3438.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.03
    Marker Score: 2181
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.02
    Marker Score: 805
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.01
    Marker Score: 2667.5

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Other Information

**Key characteristics:** - An annexin A5 protein is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the annexin family of proteins, which are involved in cell adhesion, migration, and signaling. - Annexin A5 is a key regulator of blood coagulation. It is expressed in high levels in activated platelets, where it helps to promote platelet aggregation and clot formation. - In addition to its role in blood coagulation, annexin A5 is also involved in a variety of other cellular processes, including cell migration, cell adhesion, and cell signaling. **Pathways and functions:** - Annexin A5 is involved in the regulation of blood coagulation. It is expressed in high levels in activated platelets, where it helps to promote platelet aggregation and clot formation. - In addition to its role in blood coagulation, annexin A5 is also involved in a variety of other cellular processes, including cell migration, cell adhesion, and cell signaling. - For example, annexin A5 has been shown to be involved in the migration of fibroblasts and immune cells through the tumor microenvironment. - It has also been shown to be involved in the regulation of cell adhesion, which is essential for the formation of tissues and organs. **Clinical significance:** - Mutations in the ANXA5 gene have been linked to a number of human diseases, including cancer, stroke, and heart disease. - These mutations can lead to the loss of function of annexin A5, which can result in the development of these diseases. - Therefore, ANXA5 is a promising target for the development of new drugs for cancer and other diseases that are caused by mutations in this gene.

Genular Protein ID: 522571898

Symbol: ANXA5_HUMAN

Name: Annexin A5

UniProtKB Accession Codes:

P08758 D3DNW7 Q6FHB3 Q6FI16 Q8WV69 Q9UDH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 36 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 15 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2964863

Title: Primary structure of human placental anticoagulant protein.

PubMed ID: 2964863

DOI: 10.1021/bi00399a011

PubMed ID: 2963810

Title: Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein.

PubMed ID: 2963810

DOI: 10.1093/oxfordjournals.jbchem.a122165

PubMed ID: 2455636

Title: Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein.

PubMed ID: 2455636

DOI: 10.1111/j.1432-1033.1988.tb14139.x

PubMed ID: 2967291

Title: Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.

PubMed ID: 2967291

DOI: 10.1016/s0021-9258(18)68438-8

PubMed ID: 2968983

Title: Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

PubMed ID: 2968983

DOI: 10.1016/s0021-9258(18)38041-4

PubMed ID: 2967495

Title: Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family.

PubMed ID: 2967495

DOI: 10.1073/pnas.85.11.3708

PubMed ID: 7958998

Title: The gene encoding human annexin V has a TATA-less promoter with a high G+C content.

PubMed ID: 7958998

DOI: 10.1016/0378-1119(94)90157-0

PubMed ID: 8034319

Title: Organization of the human annexin V (ANX5) gene.

PubMed ID: 8034319

DOI: 10.1006/geno.1994.1201

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2532007

Title: A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation.

PubMed ID: 2532007

DOI: 10.1042/bj2630929

PubMed ID: 8249278

Title: Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein.

PubMed ID: 8249278

DOI: 10.1006/viro.1993.1628

PubMed ID: 2957692

Title: Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein.

PubMed ID: 2957692

DOI: 10.1073/pnas.84.17.6078

PubMed ID: 2974032

Title: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor.

PubMed ID: 2974032

DOI: 10.1016/s0021-9258(18)37335-6

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 17339269

Title: A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.

PubMed ID: 17339269

DOI: 10.1093/hmg/ddm017

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 2147412

Title: The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.

PubMed ID: 2147412

DOI: 10.1002/j.1460-2075.1990.tb07605.x

PubMed ID: 2148156

Title: The calcium binding sites in human annexin V by crystal structure analysis at 2.0-A resolution. Implications for membrane binding and calcium channel activity.

PubMed ID: 2148156

DOI: 10.1016/0014-5793(90)81428-q

PubMed ID: 1311770

Title: Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.

PubMed ID: 1311770

DOI: 10.1016/0022-2836(92)90984-r

PubMed ID: 9398511

Title: Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor.

PubMed ID: 9398511

DOI: 10.1006/jmbi.1997.1375

PubMed ID: 9435213

Title: Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V.

PubMed ID: 9435213

DOI: 10.1073/pnas.95.2.455

Sequence Information:

  • Length: 320
  • Mass: 35937
  • Checksum: 45E14E3964BA4D1A
  • Sequence:
    • MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL 
FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE 
ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF 
QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV 
VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI 
KGDTSGDYKK ALLLLCGEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.