Details for: ANXA6

Gene ID: 309

Symbol: ANXA6

Ensembl ID: ENSG00000197043

Description: annexin A6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.0179
    Cell Significance Index: -42.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 132.4695
    Cell Significance Index: -33.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.4935
    Cell Significance Index: -43.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.9965
    Cell Significance Index: -44.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.5984
    Cell Significance Index: -48.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.6827
    Cell Significance Index: -44.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.9023
    Cell Significance Index: -41.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7069
    Cell Significance Index: -42.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5227
    Cell Significance Index: -25.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3050
    Cell Significance Index: -28.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1455
    Cell Significance Index: -13.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.6791
    Cell Significance Index: 72.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.4244
    Cell Significance Index: 116.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1706
    Cell Significance Index: 45.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9389
    Cell Significance Index: 115.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3748
    Cell Significance Index: 70.6400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.8278
    Cell Significance Index: 17.5000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.4990
    Cell Significance Index: 13.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.9269
    Cell Significance Index: 22.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4528
    Cell Significance Index: 291.4400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3807
    Cell Significance Index: 23.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2375
    Cell Significance Index: 56.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1412
    Cell Significance Index: 156.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9685
    Cell Significance Index: 124.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9419
    Cell Significance Index: 60.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8696
    Cell Significance Index: 23.2600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8323
    Cell Significance Index: 4.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7200
    Cell Significance Index: 53.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7121
    Cell Significance Index: 44.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6712
    Cell Significance Index: 79.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6157
    Cell Significance Index: 60.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5871
    Cell Significance Index: 406.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5462
    Cell Significance Index: 195.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5286
    Cell Significance Index: 104.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3556
    Cell Significance Index: 15.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3369
    Cell Significance Index: 25.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3310
    Cell Significance Index: 17.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3204
    Cell Significance Index: 19.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3003
    Cell Significance Index: 48.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2849
    Cell Significance Index: 10.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2726
    Cell Significance Index: 5.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2514
    Cell Significance Index: 11.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1968
    Cell Significance Index: 10.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1202
    Cell Significance Index: 20.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1097
    Cell Significance Index: 14.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1007
    Cell Significance Index: 189.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0804
    Cell Significance Index: 8.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0767
    Cell Significance Index: 14.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0714
    Cell Significance Index: 2.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0648
    Cell Significance Index: 1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0362
    Cell Significance Index: 22.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0324
    Cell Significance Index: 14.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0285
    Cell Significance Index: 0.7600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.0119
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0010
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0049
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0125
    Cell Significance Index: -0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0159
    Cell Significance Index: -24.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0338
    Cell Significance Index: -46.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0353
    Cell Significance Index: -26.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0354
    Cell Significance Index: -1.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0391
    Cell Significance Index: -28.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0410
    Cell Significance Index: -22.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0564
    Cell Significance Index: -3.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0567
    Cell Significance Index: -31.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0953
    Cell Significance Index: -20.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1088
    Cell Significance Index: -12.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1210
    Cell Significance Index: -3.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1252
    Cell Significance Index: -12.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1335
    Cell Significance Index: -38.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1357
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1595
    Cell Significance Index: -23.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1907
    Cell Significance Index: -8.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1988
    Cell Significance Index: -13.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2026
    Cell Significance Index: -36.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2553
    Cell Significance Index: -29.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2681
    Cell Significance Index: -6.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2844
    Cell Significance Index: -29.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3286
    Cell Significance Index: -37.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3325
    Cell Significance Index: -40.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3453
    Cell Significance Index: -11.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3485
    Cell Significance Index: -20.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3623
    Cell Significance Index: -25.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4398
    Cell Significance Index: -11.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4587
    Cell Significance Index: -5.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4868
    Cell Significance Index: -11.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4877
    Cell Significance Index: -7.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5048
    Cell Significance Index: -9.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5235
    Cell Significance Index: -10.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5400
    Cell Significance Index: -15.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5574
    Cell Significance Index: -44.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5621
    Cell Significance Index: -11.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5854
    Cell Significance Index: -35.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5964
    Cell Significance Index: -10.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6177
    Cell Significance Index: -10.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6415
    Cell Significance Index: -18.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6455
    Cell Significance Index: -36.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein**: ANXA6 is a calcium-binding protein, which suggests its involvement in calcium-dependent signaling pathways. 2. **Multifunctional protein**: ANXA6 has been shown to interact with various proteins and lipids, including phospholipids, cholesterol, and phosphatidylserine, indicating its broad functional range. 3. **Regulation of calcium homeostasis**: ANXA6 has been implicated in the regulation of calcium ion homeostasis in cells, particularly in the context of mitochondrial calcium ion homeostasis. 4. **Involvement in immune response**: ANXA6 is significantly expressed in immune cells, such as T cells, natural killer cells, and regulatory T cells, suggesting its role in immune response and regulation. **Pathways and Functions:** 1. **Apoptotic signaling pathway**: ANXA6 has been shown to regulate apoptosis (programmed cell death) by interacting with pro-apoptotic and anti-apoptotic proteins. 2. **Calcium-dependent phospholipid binding**: ANXA6 binds to phospholipids, which are essential for cell membrane structure and function. 3. **Calcium-dependent protein binding**: ANXA6 interacts with various proteins, including those involved in calcium signaling and membrane trafficking. 4. **Lipid binding**: ANXA6 has been shown to bind to lipids, including cholesterol and phosphatidylserine, which are essential for cell membrane structure and function. 5. **Regulation of sequestering of calcium ion**: ANXA6 has been implicated in the regulation of calcium ion sequestering in cells, particularly in the context of mitochondrial calcium ion homeostasis. **Clinical Significance:** 1. **Immune-related disorders**: ANXA6 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: ANXA6 has been shown to be overexpressed in certain types of cancer, including breast cancer and ovarian cancer, suggesting its potential role in cancer progression and metastasis. 3. **Neurological disorders**: ANXA6 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative diseases. 4. **Regulation of cell death**: ANXA6 has been shown to regulate apoptosis in various cell types, suggesting its potential role in regulating cell death in disease contexts. In conclusion, Annexin A6 is a multifaceted gene involved in various cellular processes, including immune response, cellular differentiation, and tissue homeostasis. Its involvement in calcium-dependent signaling, membrane trafficking, and cell death regulation makes it a crucial regulator of cellular homeostasis. Further studies are needed to elucidate the functional significance of ANXA6 in human disease, particularly in the context of immune-related disorders, cancer, and neurological disorders.

Genular Protein ID: 2115721325

Symbol: ANXA6_HUMAN

Name: Annexin A6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3258820

Title: Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.

PubMed ID: 3258820

DOI: 10.1002/j.1460-2075.1988.tb02779.x

PubMed ID: 2963335

Title: Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.

PubMed ID: 2963335

DOI: 10.1073/pnas.85.3.664

PubMed ID: 2528541

Title: Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor.

PubMed ID: 2528541

DOI: 10.1093/oxfordjournals.jbchem.a122816

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2139657

Title: Structure and properties of calphobindin II, an anticoagulant protein from human placenta.

PubMed ID: 2139657

DOI: 10.1093/oxfordjournals.jbchem.a123009

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8709144

Title: The structure of recombinant human annexin VI in crystals and membrane-bound.

PubMed ID: 8709144

DOI: 10.1006/jmbi.1996.0426

Sequence Information:

  • Length: 673
  • Mass: 75873
  • Checksum: 90F47474F7F6D7B6
  • Sequence:
  • MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ 
    SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA 
    SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD 
    VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 
    LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 
    LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA 
    NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE 
    ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED 
    YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK 
    TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 
    PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 
    FLKALLALCG GED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.