Details for: ANXA6

Gene ID: 309

Symbol: ANXA6

Ensembl ID: ENSG00000197043

Description: annexin A6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.9
    Marker Score: 9150
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.81
    Marker Score: 2715
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.72
    Marker Score: 17670
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.66
    Marker Score: 30905
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.65
    Marker Score: 26210
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.62
    Marker Score: 2305
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.58
    Marker Score: 11078
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.55
    Marker Score: 3762
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.52
    Marker Score: 7342
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.5
    Marker Score: 3540
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.42
    Marker Score: 4223
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.39
    Marker Score: 2249
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.35
    Marker Score: 15024
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.35
    Marker Score: 6484.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.34
    Marker Score: 4588.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.29
    Marker Score: 5573.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.27
    Marker Score: 2414
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.21
    Marker Score: 1297
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.18
    Marker Score: 5134
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.15
    Marker Score: 814
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.14
    Marker Score: 113320
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.13
    Marker Score: 5972
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.06
    Marker Score: 27157
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.98
    Marker Score: 4926
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.96
    Marker Score: 1435
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.95
    Marker Score: 2096.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.94
    Marker Score: 5084
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.93
    Marker Score: 831
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.92
    Marker Score: 2320
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.91
    Marker Score: 19206
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.89
    Marker Score: 2610
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.87
    Marker Score: 530
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.87
    Marker Score: 1664
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.87
    Marker Score: 1361
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.85
    Marker Score: 3478
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.84
    Marker Score: 522
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.84
    Marker Score: 424
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.84
    Marker Score: 2272
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.83
    Marker Score: 464
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18851.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.82
    Marker Score: 1493.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.82
    Marker Score: 1002
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.81
    Marker Score: 532
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.79
    Marker Score: 1678
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.78
    Marker Score: 1025
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.78
    Marker Score: 7678.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.78
    Marker Score: 10554
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.77
    Marker Score: 1581
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.76
    Marker Score: 1328
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.75
    Marker Score: 1154
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.75
    Marker Score: 575.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.72
    Marker Score: 3071
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.71
    Marker Score: 63255
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.71
    Marker Score: 1004.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.7
    Marker Score: 2260
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.69
    Marker Score: 467
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.69
    Marker Score: 708
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.66
    Marker Score: 6777
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.64
    Marker Score: 1189
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.63
    Marker Score: 569
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.62
    Marker Score: 783
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.62
    Marker Score: 1867
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.61
    Marker Score: 4371.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 98721
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.6
    Marker Score: 986
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.6
    Marker Score: 2203
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.6
    Marker Score: 961
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.59
    Marker Score: 1338
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.58
    Marker Score: 1773
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.58
    Marker Score: 922
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6486.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.56
    Marker Score: 757
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.55
    Marker Score: 2385
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.54
    Marker Score: 1022
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.54
    Marker Score: 2645
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14554.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.52
    Marker Score: 1195.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.52
    Marker Score: 3335
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.51
    Marker Score: 398
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.49
    Marker Score: 521
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 818
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.48
    Marker Score: 513
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1473
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.47
    Marker Score: 1845
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.47
    Marker Score: 5979
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.47
    Marker Score: 12607.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.46
    Marker Score: 13767
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.46
    Marker Score: 1375
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.45
    Marker Score: 3049
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.45
    Marker Score: 977
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.45
    Marker Score: 1398
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.44
    Marker Score: 331
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.43
    Marker Score: 481
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.43
    Marker Score: 2201
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.43
    Marker Score: 442
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.43
    Marker Score: 1030
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.43
    Marker Score: 677
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.42
    Marker Score: 286.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.41
    Marker Score: 1649
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.41
    Marker Score: 1341

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Other Information

**Key characteristics:** - It is a protein of the annexin family, which are a group of proteins that are involved in cell-cell adhesion and signaling. - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in immune cells, including gamma-delta T cells, double-negative T regulatory cells, interstitial cells of the ovary, blood cells, mature T cells, CD4-positive and CD8-positive cytotoxic T cells, T-helper 22 cells, effector memory CD8-positive T cells, and NKp46-positive innate lymphoid cells. **Pathways and functions:** - Annexin A6 is involved in the apoptotic signaling pathway. It is a key regulator of apoptosis in T cells and is required for the maintenance of immune homeostasis. - It is also involved in calcium signaling and muscle contraction. - It is a key regulator of the immune response. It is expressed in high levels in immune cells, and its expression is upregulated in response to a variety of stimuli, including cytokines and immune cells. - Annexin A6 is also involved in the regulation of cholesterol transport and mitochondrial calcium homeostasis. **Clinical significance:** - Mutations in the ANXA6 gene have been linked to a number of human diseases, including cancer and autoimmune disorders. - Annexin A6 is a promising target for cancer therapy. Several drugs that target annexin A6 have been tested in clinical trials, and one, Carfilzomib, has been approved for the treatment of multiple myeloma.

Genular Protein ID: 2115721325

Symbol: ANXA6_HUMAN

Name: Annexin A6

UniProtKB Accession Codes:

P08133 B7Z8A7 D3DQH4 E9PGK1 Q6ZT79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3258820

Title: Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.

PubMed ID: 3258820

DOI: 10.1002/j.1460-2075.1988.tb02779.x

PubMed ID: 2963335

Title: Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.

PubMed ID: 2963335

DOI: 10.1073/pnas.85.3.664

PubMed ID: 2528541

Title: Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor.

PubMed ID: 2528541

DOI: 10.1093/oxfordjournals.jbchem.a122816

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2139657

Title: Structure and properties of calphobindin II, an anticoagulant protein from human placenta.

PubMed ID: 2139657

DOI: 10.1093/oxfordjournals.jbchem.a123009

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8709144

Title: The structure of recombinant human annexin VI in crystals and membrane-bound.

PubMed ID: 8709144

DOI: 10.1006/jmbi.1996.0426

Sequence Information:

  • Length: 673
  • Mass: 75873
  • Checksum: 90F47474F7F6D7B6
  • Sequence:
    • MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ 
SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA 
SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD 
VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 
LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA 
NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE 
ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED 
YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK 
TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 
FLKALLALCG GED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.