Angptl3 | ENSMUSG00000028553 | NCBI 30924

Details for: Angptl3

Gene ID: 30924

Symbol: Angptl3

Ensembl ID: ENSMUSG00000028553

Description: angiopoietin-like 3

Associated with

Assembly of active lpl and lipc lipase complexes
(R-MMU-8963889)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Transport of small molecules
(R-MMU-382551)
Acylglycerol homeostasis
(GO:0055090)
Angiogenesis
(GO:0001525)
Artery morphogenesis
(GO:0048844)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Collagen-containing extracellular matrix
(GO:0062023)
Early endosome
(GO:0005769)
Enzyme inhibitor activity
(GO:0004857)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid metabolic process
(GO:0006631)
Glycerol metabolic process
(GO:0006071)
Golgi apparatus
(GO:0005794)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Integrin binding
(GO:0005178)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Lipid storage
(GO:0019915)
Negative regulation of lipoprotein lipase activity
(GO:0051005)
Negative regulation of phospholipase activity
(GO:0010519)
Phospholipase inhibitor activity
(GO:0004859)
Phospholipid catabolic process
(GO:0009395)
Phospholipid homeostasis
(GO:0055091)
Phospholipid metabolic process
(GO:0006644)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of lipid catabolic process
(GO:0050996)
Positive regulation of lipid metabolic process
(GO:0045834)
Signal transduction
(GO:0007165)
Triglyceride homeostasis
(GO:0070328)
Triglyceride metabolic process
(GO:0006641)

Other Information

Proteins

Angiopoietin-related protein 3

Genular Protein ID: 189372558

Symbol: ANGL3_MOUSE

Name: Angiopoietin-related protein 3

UniProtKB Accession Codes:

Q9R182

Database IDs:

Citations:

PubMed ID: 10644446

Title: Identification of a mammalian angiopoietin-related protein expressed specifically in liver.

PubMed ID: 10644446

DOI: 10.1006/geno.1999.6041

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11877390

Title: ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.

PubMed ID: 11877390

DOI: 10.1074/jbc.m109768200

PubMed ID: 11788823

Title: Angptl3 regulates lipid metabolism in mice.

PubMed ID: 11788823

DOI: 10.1038/ng814

PubMed ID: 12909640

Title: Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

PubMed ID: 12909640

DOI: 10.1074/jbc.m302861200

PubMed ID: 12671033

Title: A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice.

PubMed ID: 12671033

DOI: 10.1194/jlr.m300031-jlr200

PubMed ID: 15336575

Title: Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor.

PubMed ID: 15336575

DOI: 10.1016/j.bbrc.2004.08.024

PubMed ID: 15863837

Title: Differential regulation and properties of angiopoietin-like proteins 3 and 4.

PubMed ID: 15863837

DOI: 10.1194/jlr.m500005-jlr200

PubMed ID: 16081640

Title: Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.

PubMed ID: 16081640

DOI: 10.1210/en.2005-0476

PubMed ID: 16508209

Title: Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity.

PubMed ID: 16508209

DOI: 10.1538/expanim.55.27

PubMed ID: 17110602

Title: Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.

PubMed ID: 17110602

DOI: 10.1161/01.atv.0000252827.51626.89

PubMed ID: 17681148

Title: Hepatic proprotein convertases modulate HDL metabolism.

PubMed ID: 17681148

DOI: 10.1016/j.cmet.2007.07.009

PubMed ID: 20633534

Title: Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro.

PubMed ID: 20633534

DOI: 10.1016/j.bbrc.2010.07.027

PubMed ID: 20581395

Title: Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases.

PubMed ID: 20581395

DOI: 10.1074/jbc.m110.144279

PubMed ID: 20424482

Title: Expression of angiopoietin-like 3 associated with puromycin-induced podocyte damage.

PubMed ID: 20424482

DOI: 10.1159/000313829

PubMed ID: 20959605

Title: Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche.

PubMed ID: 20959605

DOI: 10.1182/blood-2010-06-291716

PubMed ID: 24294595

Title: Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin alpha(V)beta(3)/FAK/PI3K pathway-mediated Rac1 activation.

PubMed ID: 24294595

DOI: 10.1155/2013/135608

PubMed ID: 23918928

Title: Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.

PubMed ID: 23918928

DOI: 10.1074/jbc.m113.501304

PubMed ID: 25338813

Title: Regulation of energy balance by the hypothalamic lipoprotein lipase regulator Angptl3.

PubMed ID: 25338813

DOI: 10.2337/db14-0647

PubMed ID: 25954050

Title: Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.

PubMed ID: 25954050

DOI: 10.1194/jlr.m054882

PubMed ID: 25710887

Title: A novel role of angiopoietin-like-3 associated with podocyte injury.

PubMed ID: 25710887

DOI: 10.1038/pr.2015.38

PubMed ID: 26305978

Title: Hepatic ANGPTL3 regulates adipose tissue energy homeostasis.

PubMed ID: 26305978

DOI: 10.1073/pnas.1515374112

Sequence Information:

Length: 455
Mass: 52543
Checksum: 31609D3700D3F33D
Sequence:

MHTIKLFLFV VPLVIASRVD PDLSSFDSAP SEPKSRFAML DDVKILANGL LQLGHGLKDF 
VHKTKGQIND IFQKLNIFDQ SFYDLSLRTN EIKEEEKELR RTTSTLQVKN EEVKNMSVEL 
NSKLESLLEE KTALQHKVRA LEEQLTNLIL SPAGAQEHPE VTSLKSFVEQ QDNSIRELLQ 
SVEEQYKQLS QQHMQIKEIE KQLRKTGIQE PSENSLSSKS RAPRTTPPLQ LNETENTEQD 
DLPADCSAVY NRGEHTSGVY TIKPRNSQGF NVYCDTQSGS PWTLIQHRKD GSQDFNETWE 
NYEKGFGRLD GEFWLGLEKI YAIVQQSNYI LRLELQDWKD SKHYVEYSFH LGSHETNYTL 
HVAEIAGNIP GALPEHTDLM FSTWNHRAKG QLYCPESYSG GWWWNDICGE NNLNGKYNKP 
RTKSRPERRR GIYWRPQSRK LYAIKSSKMM LQPTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Angptl3

Associated with

Other Information

Identification of a mammalian angiopoietin-related protein expressed specifically in liver. PubMed ID: 10644446

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. PubMed ID: 11877390

Angptl3 regulates lipid metabolism in mice. PubMed ID: 11788823

Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. PubMed ID: 12909640

A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. PubMed ID: 12671033

Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. PubMed ID: 15336575

Differential regulation and properties of angiopoietin-like proteins 3 and 4. PubMed ID: 15863837

Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. PubMed ID: 16081640

Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. PubMed ID: 16508209

Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. PubMed ID: 17110602

Hepatic proprotein convertases modulate HDL metabolism. PubMed ID: 17681148

Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro. PubMed ID: 20633534

Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. PubMed ID: 20581395

Expression of angiopoietin-like 3 associated with puromycin-induced podocyte damage. PubMed ID: 20424482

Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. PubMed ID: 20959605

Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin alpha(V)beta(3)/FAK/PI3K pathway-mediated Rac1 activation. PubMed ID: 24294595

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. PubMed ID: 23918928

Regulation of energy balance by the hypothalamic lipoprotein lipase regulator Angptl3. PubMed ID: 25338813

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. PubMed ID: 25954050

A novel role of angiopoietin-like-3 associated with podocyte injury. PubMed ID: 25710887

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. PubMed ID: 26305978