Slamf6 | ENSMUSG00000015314 | NCBI 30925

Details for: Slamf6

Gene ID: 30925

Symbol: Slamf6

Ensembl ID: ENSMUSG00000015314

Description: SLAM family member 6

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Natural killer cell differentiation
(GO:0001779)
Natural killer cell proliferation
(GO:0001787)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of type ii interferon production
(GO:0032729)
T-helper 17 cell lineage commitment
(GO:0072540)
T cell activation
(GO:0042110)

Other Information

Proteins

SLAM family member 6
Q18PG5_MOUSE

Genular Protein ID: 868941052

Symbol: SLAF6_MOUSE

Name: SLAM family member 6

UniProtKB Accession Codes:

Q9ET39 C6ESQ1 Q9ET40

Database IDs:

Citations:

PubMed ID: 11132158

Title: Ly108: a new member of the mouse CD2 family of cell surface proteins.

PubMed ID: 11132158

DOI: 10.1007/s002510000252

PubMed ID: 21422172

Title: A novel isoform of the Ly108 gene ameliorates murine lupus.

PubMed ID: 21422172

DOI: 10.1084/jem.20101653

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18031695

Title: Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.

PubMed ID: 18031695

DOI: 10.1016/j.immuni.2007.08.020

PubMed ID: 19648922

Title: Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.

PubMed ID: 19648922

DOI: 10.1038/ni.1763

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20153220

Title: Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

PubMed ID: 20153220

DOI: 10.1016/j.immuni.2010.01.010

PubMed ID: 22683125

Title: The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

PubMed ID: 22683125

DOI: 10.1016/j.immuni.2012.05.016

PubMed ID: 25926831

Title: Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors.

PubMed ID: 25926831

DOI: 10.3389/fimmu.2015.00158

PubMed ID: 25801429

Title: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.

PubMed ID: 25801429

DOI: 10.4049/jimmunol.1403023

Sequence Information:

Length: 351
Mass: 38638
Checksum: A8DD9EBF650FB431
Sequence:

MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK 
IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS 
YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE 
WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA 
VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 
PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN S

Genular Protein ID: 1987923129

Symbol: Q18PG5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q18PG5

Database IDs:

Sequence Information:

Length: 331
Mass: 36440
Checksum: 7E1A056C8C0A716A
Sequence:

MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK 
IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS 
YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE 
WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA 
VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 
PMQEMKIPKP IKNDSMTIYS IVNHSREAEY S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slamf6

Associated with

Other Information

Ly108: a new member of the mouse CD2 family of cell surface proteins. PubMed ID: 11132158

A novel isoform of the Ly108 gene ameliorates murine lupus. PubMed ID: 21422172

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. PubMed ID: 18031695

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. PubMed ID: 19648922

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. PubMed ID: 20153220

The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. PubMed ID: 22683125

Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors. PubMed ID: 25926831

B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. PubMed ID: 25801429