Details for: Pik3cg

Gene ID: 30955

Symbol: Pik3cg

Ensembl ID: ENSMUSG00000020573

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Associated with

Other Information

Genular Protein ID: 1710449221

Symbol: PK3CG_MOUSE

Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

UniProtKB Accession Codes:

Q9JHG7 Q80V09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EC 4 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 41 Gene3D 4 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MGI 1 MaxQB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 7 PROSITE-ProRule 5 PaxDb 1 Pfam 5 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 10 SMART 4 SMR 1 STRING 1 SUPFAM 4 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 11054537

Title: Analysis of the murine phosphoinositide 3-kinase gamma gene.

PubMed ID: 11054537

DOI: 10.1016/s0378-1119(00)00328-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10669416

Title: Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.

PubMed ID: 10669416

DOI: 10.1126/science.287.5455.1040

PubMed ID: 10669418

Title: Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

PubMed ID: 10669418

DOI: 10.1126/science.287.5455.1049

PubMed ID: 11416136

Title: The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.

PubMed ID: 11416136

DOI: 10.1128/mcb.21.14.4579-4597.2001

PubMed ID: 12297047

Title: Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.

PubMed ID: 12297047

DOI: 10.1016/s0092-8674(02)00969-8

PubMed ID: 15294162

Title: PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

PubMed ID: 15294162

DOI: 10.1016/j.cell.2004.07.017

PubMed ID: 15318168

Title: Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.

PubMed ID: 15318168

DOI: 10.1038/sj.emboj.7600361

PubMed ID: 16116162

Title: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

PubMed ID: 16116162

DOI: 10.4049/jimmunol.175.5.2783

PubMed ID: 16127437

Title: Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

PubMed ID: 16127437

DOI: 10.1038/nm1284

PubMed ID: 17673465

Title: Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.

PubMed ID: 17673465

DOI: 10.1074/jbc.m704358200

PubMed ID: 19297623

Title: p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.

PubMed ID: 19297623

DOI: 10.1073/pnas.0808594106

PubMed ID: 19906996

Title: Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.

PubMed ID: 19906996

DOI: 10.1073/pnas.0905506106

PubMed ID: 21474070

Title: Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110gamma.

PubMed ID: 21474070

DOI: 10.1016/j.molcel.2011.01.030

PubMed ID: 31554793

Title: Human PI3Kgamma deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

PubMed ID: 31554793

DOI: 10.1038/s41467-019-12311-5

Sequence Information:

  • Length: 1102
  • Mass: 126400
  • Checksum: 7675848792D76734
  • Sequence:
    • MELENYEQPV VLREDNLRRR RRMKPRSAAG SLSSMELIPI EFVLPTSQRI SKTPETALLH 
VAGHGNVEQM KAQVWLRALE TSVAAEFYHR LGPDQFLLLY QKKGQWYEIY DRYQVVQTLD 
CLHYWKLMHK SPGQIHVVQR HVPSEETLAF QKQLTSLIGY DVTDISNVHD DELEFTRRRL 
VTPRMAEVAG RDAKLYAMHP WVTSKPLPDY LSKKIANNCI FIVIHRGTTS QTIKVSADDT 
PGTILQSFFT KMAKKKSLMN ISESQSEQDF VLRVCGRDEY LVGETPLKNF QWVRQCLKNG 
DEIHLVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK 
FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFAEEVLW NVWLEFGIKI 
KDLPKGALLN LQIYCCKTPS LSSKASAETP GSESKGKAQL LYYVNLLLID HRFLLRHGDY 
VLHMWQISGK AEEQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHRPTPDPEG 
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ 
QEIVAKTYQL LARREIWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL 
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY 
LRGCGTAMLQ DFTQQVHVIE MLQKVTIDIK SLSAEKYDVS SQVISQLKQK LESLQNSNLP 
ESFRVPYDPG LKAGTLVIEK CKVMASKKKP LWLEFKCADP TVLSNETIGI IFKHGDDLRQ 
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAQ IQQSTVGNTG 
AFKDEVLNHW LKEKCPIEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMISETGNL 
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGSSGK KTSPHFQKFQ DVCVRAYLAL 
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKS EEDAKKYFLD QIEVCRDKGW 
TVQFNWFLHL VLGIKQGEKH SA

Genular Protein ID: 2501733358

Symbol: Q8C5Q7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C5Q7

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 InterPro 5 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 RefSeq 3 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 260
  • Mass: 29642
  • Checksum: 0FB638590D13BCC5
  • Sequence:
    • MILQILRIME SIWETESLDL CLLPYGCIST GDKIGMIEIV KDATTIAQIQ QSTVGNTGAF 
KDEVLNHWLK EKCPIEEKFQ AAVERFVYSC AGYCVATFVL GIGDRHNDNI MISETGNLFH 
IDFGHILGNY KSFLGINKER VPFVLTPDFL FVMGSSGKKT SPHFQKFQDV YVRAYLALRH 
HTNLLIILFS MMLMTGMPQL TSKEDIEYIR DALTVGKSEE DAKKYFLDQI EVCRDKGWTV 
QFNWFLHLVL GIKQGEKHSA

Genular Protein ID: 3467083115

Symbol: Q3UVA4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UVA4

Database IDs:

AGR 1 ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 GO 5 Gene3D 4 Genevisible 1 InterPro 14 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 12 PeptideAtlas 1 Pfam 5 RefSeq 3 Rhea 2 SMART 4 SUPFAM 4 UniPathway 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 1102
  • Mass: 126472
  • Checksum: 22963359F9E830EA
  • Sequence:
    • MELENYEQPV VLREDNLRRR RRMKPRSAAG SLSSMELIPI EFVLPTSQRI SKTPETALLH 
VAGHGNVEQM KAQVWLRALE TSVAAEFYHR LGPDQFLLLY QKKGQWYEIY DRYQVVQTLD 
CLHYWKLMHK SPGQIHVVQR HVPSEETLAF QKQLTSLIGY DVTDISNVHD DELEFTRRRL 
VTPRMAEVAG RDAKLYAMHP WVTSKPLPDY LSKKIANNCI FIVIHRGTTS QTIKVSADDT 
PGTILQSFFT KMAKKKSLMN ISESQSEQDF VLRVCGRDEY LVGETPLKNF QWVRQCLKNG 
DEIHLVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK 
FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFAEEVLW NVWLEFGIKI 
KDLPKGALLN LQIYCCKTPS LSSKASAETP GSESKGKAQL LYYVNLLLID HRFLLRHGDY 
VLHMWQISGK AEEQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHRPTPDPEG 
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ 
QEIVAKTYQL LARREIWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL 
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY 
LRGCGTAMLQ DFTQQVHVIE MLQKVTIDIK SLSAEKYDVS SQVISQLKQK LESLQNSNLP 
ESFRVPYDPG LKAGTLVIEK CKVMASKKKP LWLEFKCADP TVLSNETIGI IFKHGDDLRQ 
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAQ IQQSTVGNTE 
AFKDEVLNHW LKEKCPIEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMISETGNL 
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGSSGK KTSPHFQKFQ DVCVRAYLAL 
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKS EEDAKKYFLD QIEVCRDKGW 
TVQFNWFLHL VLGIKQGEKH SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.