Details for: ACACA

Gene ID: 31

Symbol: ACACA

Ensembl ID: ENSG00000278540

Description: acetyl-CoA carboxylase alpha

Associated with

Other Information

Genular Protein ID: 2995344937

Symbol: ACACA_HUMAN

Name: Acetyl-Coenzyme A carboxylase alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7732023

Title: Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.

PubMed ID: 7732023

DOI: 10.1073/pnas.92.9.4011

PubMed ID: 12810950

Title: Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region.

PubMed ID: 12810950

DOI: 10.1073/pnas.1332670100

PubMed ID: 15333468

Title: Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.

PubMed ID: 15333468

DOI: 10.1093/carcin/bgh273

PubMed ID: 18487259

Title: Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.

PubMed ID: 18487259

DOI: 10.1093/dnares/dsn010

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14643797

Title: Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects.

PubMed ID: 14643797

DOI: 10.1016/j.bbalip.2003.09.005

PubMed ID: 15607423

Title: Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes.

PubMed ID: 15607423

DOI: 10.1016/j.ygeno.2004.10.001

PubMed ID: 12360400

Title: BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.

PubMed ID: 12360400

DOI: 10.1038/sj.onc.1205915

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16326698

Title: BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.

PubMed ID: 16326698

DOI: 10.1074/jbc.m504652200

PubMed ID: 16698035

Title: ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.

PubMed ID: 16698035

DOI: 10.1016/j.jmb.2006.04.010

PubMed ID: 6114432

Title: Acetyl-CoA carboxylase deficiency: an inborn error of de novo fatty acid synthesis.

PubMed ID: 6114432

DOI: 10.1056/nejm198108203050820

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20457939

Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

PubMed ID: 20457939

DOI: 10.1073/pnas.1001292107

PubMed ID: 20952656

Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.

PubMed ID: 20952656

DOI: 10.1073/pnas.1012736107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18452305

Title: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.

PubMed ID: 18452305

DOI: 10.1021/bi800314m

PubMed ID: 29899443

Title: Structural basis for regulation of human acetyl-CoA carboxylase.

PubMed ID: 29899443

DOI: 10.1038/s41586-018-0201-4

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 2346
  • Mass: 265554
  • Checksum: F1F0A518F8824FFC
  • Sequence:
  • MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS 
    DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK 
    VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG 
    GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL 
    GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA 
    AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV 
    QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA 
    GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY 
    GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY 
    FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET 
    ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV 
    LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG 
    SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA 
    EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ 
    STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ 
    DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV 
    FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD 
    MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR 
    ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH 
    SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM 
    SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP 
    PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV 
    DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ 
    LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE 
    YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG 
    SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA 
    YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA 
    FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI 
    GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD 
    PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS 
    GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR 
    EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID 
    RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG 
    IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL 
    MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI 
    NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE 
    RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR 
    RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE 
    EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST 
    MDSPST

Genular Protein ID: 1115952276

Symbol: Q7Z5W8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 690
  • Mass: 78272
  • Checksum: 54814516C7A58A06
  • Sequence:
  • IGMVAWKMTF KSPEYPEGRD IIVIGNDITY RIGSFGPQED LLFLRASELA RAEGIPRIYV 
    SANSGARIGL AEEIRHMFHV AWVDPEDPYK GYRYLYLTPQ DYKRVSALNS VHCEHVEDEG 
    ESRYKITDII GKEEGIGPEN LRGSGMIAGE SSLAYNEIIT ISLVTCRAIG IGAYLVRLGQ 
    RTIQVENSHL ILTGAGALNK VLGREVYTSN NQLGGIQIMH NNGVTHCTVC DDFEGVFTVL 
    HWLSYMPKSV HSSVPLLNSK DPIDRIIEFV PTKTPYDPRW MLAGRPHPTQ KGQWLSGFFD 
    YGSFSEIMQP WAQTVVVGRA RLGGIPVGVV AVETRTVELS IPADPANLDS EAKIIQQAGQ 
    VWFPDSAFKT YQAIKDFNRE GLPLMVFANW RGFSGGMKDM YDQVLKFGAY IVDGLRECCQ 
    PVLVYIPPQA ELRGGSWVVI DSSINPRHME MYADRESRGS VLEPEGTVEI KFRRKDLVKT 
    MRRVDPVYIH LAERLGTPEL STAERKELEN KLKEREEFLI PIYHQVAVQF ADLHDTPGRM 
    QEKGVISDIL DWKTSRTFFY WRLRRLLLED LVKKKIHNAN PELTDGQIQA MLRRWFVEVE 
    GTVKAYVWDN NKDLAEWLEK QLTEEDGVHS VIEENIKCIS RDYVLKQIRS LVQANPEVAM 
    DSIIHMTQHI SPTQRAEVIR ILSTMDSPST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.