Details for: ACACA

Gene ID: 31

Symbol: ACACA

Ensembl ID: ENSG00000278540

Description: acetyl-CoA carboxylase alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 145.8519
    Cell Significance Index: -68.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.2317
    Cell Significance Index: -50.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.0300
    Cell Significance Index: -50.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.3219
    Cell Significance Index: -65.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.5684
    Cell Significance Index: -38.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 9.3606
    Cell Significance Index: 296.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.9032
    Cell Significance Index: 109.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.1485
    Cell Significance Index: 68.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8807
    Cell Significance Index: 577.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8787
    Cell Significance Index: 161.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8567
    Cell Significance Index: 566.9200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.8051
    Cell Significance Index: 24.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4719
    Cell Significance Index: 886.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.3770
    Cell Significance Index: 35.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.3517
    Cell Significance Index: 89.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.3383
    Cell Significance Index: 103.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7731
    Cell Significance Index: 1226.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3729
    Cell Significance Index: 35.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1555
    Cell Significance Index: 88.6700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.0435
    Cell Significance Index: 10.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9703
    Cell Significance Index: 157.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9530
    Cell Significance Index: 860.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6958
    Cell Significance Index: 125.4300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.6363
    Cell Significance Index: 2.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5498
    Cell Significance Index: 27.7800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.5122
    Cell Significance Index: 3.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4460
    Cell Significance Index: 23.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4333
    Cell Significance Index: 589.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3799
    Cell Significance Index: 6.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3720
    Cell Significance Index: 40.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3339
    Cell Significance Index: 41.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3169
    Cell Significance Index: 9.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2762
    Cell Significance Index: 520.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2615
    Cell Significance Index: 402.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2597
    Cell Significance Index: 4.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2558
    Cell Significance Index: 162.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2237
    Cell Significance Index: 412.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2191
    Cell Significance Index: 99.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2164
    Cell Significance Index: 118.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1906
    Cell Significance Index: 4.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1281
    Cell Significance Index: 5.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0937
    Cell Significance Index: 9.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0570
    Cell Significance Index: 10.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0334
    Cell Significance Index: 1.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0160
    Cell Significance Index: -7.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0371
    Cell Significance Index: -28.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0425
    Cell Significance Index: -31.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0711
    Cell Significance Index: -52.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0825
    Cell Significance Index: -5.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0970
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1032
    Cell Significance Index: -58.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1273
    Cell Significance Index: -18.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1326
    Cell Significance Index: -82.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1488
    Cell Significance Index: -3.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1506
    Cell Significance Index: -20.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1674
    Cell Significance Index: -3.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1735
    Cell Significance Index: -8.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2166
    Cell Significance Index: -62.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2296
    Cell Significance Index: -23.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2371
    Cell Significance Index: -27.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2454
    Cell Significance Index: -28.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3027
    Cell Significance Index: -63.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3141
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3181
    Cell Significance Index: -54.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3205
    Cell Significance Index: -6.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3223
    Cell Significance Index: -6.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3499
    Cell Significance Index: -45.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3524
    Cell Significance Index: -36.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3588
    Cell Significance Index: -16.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4191
    Cell Significance Index: -49.4200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4286
    Cell Significance Index: -5.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4512
    Cell Significance Index: -14.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4610
    Cell Significance Index: -4.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4968
    Cell Significance Index: -31.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5026
    Cell Significance Index: -8.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5177
    Cell Significance Index: -66.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5227
    Cell Significance Index: -7.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5535
    Cell Significance Index: -18.1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5638
    Cell Significance Index: -7.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5741
    Cell Significance Index: -42.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5900
    Cell Significance Index: -8.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6479
    Cell Significance Index: -20.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6983
    Cell Significance Index: -10.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7286
    Cell Significance Index: -37.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7343
    Cell Significance Index: -58.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7369
    Cell Significance Index: -45.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7686
    Cell Significance Index: -49.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8054
    Cell Significance Index: -11.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8179
    Cell Significance Index: -10.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8385
    Cell Significance Index: -59.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.9318
    Cell Significance Index: -12.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9369
    Cell Significance Index: -32.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9547
    Cell Significance Index: -19.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9559
    Cell Significance Index: -23.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9672
    Cell Significance Index: -50.7800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.0024
    Cell Significance Index: -15.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0119
    Cell Significance Index: -21.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0146
    Cell Significance Index: -21.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0919
    Cell Significance Index: -29.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACCα is a biotin-dependent enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a key step in fatty acid synthesis. This reaction is reversible, and the enzyme's activity is regulated by various factors, including biotin, ATP, and transcription factors such as SREBF (sterol regulatory element-binding factor). ACCα is primarily expressed in tissues involved in lipid metabolism, including adipose tissue, liver, and skeletal muscle. The gene is highly conserved across species, with significant homology to other acetyl-CoA carboxylase enzymes. **Pathways and Functions** ACCα is involved in several key metabolic pathways, including: 1. **Fatty acid biosynthesis**: ACCα catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which is then used to synthesize fatty acids. 2. **Lipid homeostasis**: ACCα regulates the balance of fatty acids in the body, influencing lipogenesis, lipolysis, and lipid storage. 3. **Energy metabolism**: ACCα is involved in the regulation of energy homeostasis by modulating the synthesis and oxidation of fatty acids. 4. **Vitamin and cofactor metabolism**: ACCα is dependent on biotin for its enzymatic activity, highlighting its connection to vitamin and cofactor metabolism. **Clinical Significance** Dysregulation of ACCα has been implicated in various metabolic disorders, including: 1. **Multiple carboxylase deficiency**: Mutations in the ACACA gene can lead to multiple carboxylase deficiency, a rare genetic disorder characterized by impaired biotin metabolism. 2. **Biotin metabolism disorders**: Defects in biotin metabolism, including biotinidase deficiency, can also affect ACCα activity and function. 3. **Metabolic syndrome**: ACCα dysregulation has been linked to metabolic syndrome, a cluster of conditions characterized by impaired glucose and lipid metabolism. 4. **Atherosclerosis**: ACCα has been implicated in the development of atherosclerosis, a cardiovascular disease characterized by the buildup of fatty plaques in arteries. In conclusion, the ACACA gene plays a critical role in regulating lipid metabolism and energy homeostasis. Dysregulation of ACCα has been implicated in various metabolic disorders, highlighting its importance in human health. Further research is needed to fully understand the mechanisms by which ACCα regulates fatty acid synthesis and lipid metabolism, and to develop effective therapeutic strategies for the treatment of metabolic disorders associated with ACCα dysfunction.

Genular Protein ID: 2995344937

Symbol: ACACA_HUMAN

Name: Acetyl-Coenzyme A carboxylase alpha

UniProtKB Accession Codes:

Q13085 B2RP68 B2ZZ90 Q6KEV6 Q6XDA8 Q7Z2G8 Q7Z561 Q7Z563 Q7Z564 Q86WB2 Q86WB3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 ELM 1 EMBL 16 EMDB 3 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 9 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7732023

Title: Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.

PubMed ID: 7732023

DOI: 10.1073/pnas.92.9.4011

PubMed ID: 12810950

Title: Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region.

PubMed ID: 12810950

DOI: 10.1073/pnas.1332670100

PubMed ID: 15333468

Title: Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.

PubMed ID: 15333468

DOI: 10.1093/carcin/bgh273

PubMed ID: 18487259

Title: Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.

PubMed ID: 18487259

DOI: 10.1093/dnares/dsn010

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14643797

Title: Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects.

PubMed ID: 14643797

DOI: 10.1016/j.bbalip.2003.09.005

PubMed ID: 15607423

Title: Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes.

PubMed ID: 15607423

DOI: 10.1016/j.ygeno.2004.10.001

PubMed ID: 12360400

Title: BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.

PubMed ID: 12360400

DOI: 10.1038/sj.onc.1205915

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16326698

Title: BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.

PubMed ID: 16326698

DOI: 10.1074/jbc.m504652200

PubMed ID: 16698035

Title: ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.

PubMed ID: 16698035

DOI: 10.1016/j.jmb.2006.04.010

PubMed ID: 6114432

Title: Acetyl-CoA carboxylase deficiency: an inborn error of de novo fatty acid synthesis.

PubMed ID: 6114432

DOI: 10.1056/nejm198108203050820

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20457939

Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

PubMed ID: 20457939

DOI: 10.1073/pnas.1001292107

PubMed ID: 20952656

Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.

PubMed ID: 20952656

DOI: 10.1073/pnas.1012736107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18452305

Title: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.

PubMed ID: 18452305

DOI: 10.1021/bi800314m

PubMed ID: 29899443

Title: Structural basis for regulation of human acetyl-CoA carboxylase.

PubMed ID: 29899443

DOI: 10.1038/s41586-018-0201-4

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 2346
  • Mass: 265554
  • Checksum: F1F0A518F8824FFC
  • Sequence:
    • MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS 
DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK 
VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG 
GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL 
GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA 
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV 
QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA 
GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY 
GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY 
FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET 
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV 
LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG 
SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA 
EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ 
STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ 
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV 
FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD 
MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR 
ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH 
SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM 
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP 
PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV 
DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ 
LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE 
YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG 
SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA 
YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA 
FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI 
GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD 
PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS 
GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR 
EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID 
RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG 
IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL 
MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI 
NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE 
RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR 
RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE 
EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST 
MDSPST

Genular Protein ID: 1115952276

Symbol: Q7Z5W8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z5W8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 690
  • Mass: 78272
  • Checksum: 54814516C7A58A06
  • Sequence:
    • IGMVAWKMTF KSPEYPEGRD IIVIGNDITY RIGSFGPQED LLFLRASELA RAEGIPRIYV 
SANSGARIGL AEEIRHMFHV AWVDPEDPYK GYRYLYLTPQ DYKRVSALNS VHCEHVEDEG 
ESRYKITDII GKEEGIGPEN LRGSGMIAGE SSLAYNEIIT ISLVTCRAIG IGAYLVRLGQ 
RTIQVENSHL ILTGAGALNK VLGREVYTSN NQLGGIQIMH NNGVTHCTVC DDFEGVFTVL 
HWLSYMPKSV HSSVPLLNSK DPIDRIIEFV PTKTPYDPRW MLAGRPHPTQ KGQWLSGFFD 
YGSFSEIMQP WAQTVVVGRA RLGGIPVGVV AVETRTVELS IPADPANLDS EAKIIQQAGQ 
VWFPDSAFKT YQAIKDFNRE GLPLMVFANW RGFSGGMKDM YDQVLKFGAY IVDGLRECCQ 
PVLVYIPPQA ELRGGSWVVI DSSINPRHME MYADRESRGS VLEPEGTVEI KFRRKDLVKT 
MRRVDPVYIH LAERLGTPEL STAERKELEN KLKEREEFLI PIYHQVAVQF ADLHDTPGRM 
QEKGVISDIL DWKTSRTFFY WRLRRLLLED LVKKKIHNAN PELTDGQIQA MLRRWFVEVE 
GTVKAYVWDN NKDLAEWLEK QLTEEDGVHS VIEENIKCIS RDYVLKQIRS LVQANPEVAM 
DSIIHMTQHI SPTQRAEVIR ILSTMDSPST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.