Details for: ANXA7

Gene ID: 310

Symbol: ANXA7

Ensembl ID: ENSG00000138279

Description: annexin A7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.2915
    Cell Significance Index: -47.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.6800
    Cell Significance Index: -41.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.2350
    Cell Significance Index: -53.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.5210
    Cell Significance Index: -48.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.2410
    Cell Significance Index: -54.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.0939
    Cell Significance Index: -53.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.0986
    Cell Significance Index: -55.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.0085
    Cell Significance Index: -48.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.4742
    Cell Significance Index: -48.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.3938
    Cell Significance Index: -44.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2953
    Cell Significance Index: -56.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0396
    Cell Significance Index: -37.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6520
    Cell Significance Index: -27.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.9673
    Cell Significance Index: 482.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1247
    Cell Significance Index: 127.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0395
    Cell Significance Index: 221.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7580
    Cell Significance Index: 47.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6323
    Cell Significance Index: 327.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5876
    Cell Significance Index: 118.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5768
    Cell Significance Index: 284.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4902
    Cell Significance Index: 39.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3973
    Cell Significance Index: 65.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3933
    Cell Significance Index: 171.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3336
    Cell Significance Index: 62.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3151
    Cell Significance Index: 12.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2118
    Cell Significance Index: 31.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1475
    Cell Significance Index: 33.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1143
    Cell Significance Index: 153.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0562
    Cell Significance Index: 576.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9107
    Cell Significance Index: 116.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8681
    Cell Significance Index: 112.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8598
    Cell Significance Index: 308.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8308
    Cell Significance Index: 164.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8233
    Cell Significance Index: 81.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8116
    Cell Significance Index: 42.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7234
    Cell Significance Index: 319.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6842
    Cell Significance Index: 44.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5857
    Cell Significance Index: 30.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5381
    Cell Significance Index: 38.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5172
    Cell Significance Index: 39.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4342
    Cell Significance Index: 82.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3869
    Cell Significance Index: 45.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3494
    Cell Significance Index: 6.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3352
    Cell Significance Index: 9.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2926
    Cell Significance Index: 6.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2265
    Cell Significance Index: 15.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1887
    Cell Significance Index: 32.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1668
    Cell Significance Index: 4.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1385
    Cell Significance Index: 2.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0606
    Cell Significance Index: 1.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0575
    Cell Significance Index: 108.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0382
    Cell Significance Index: 24.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0316
    Cell Significance Index: 23.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0303
    Cell Significance Index: 22.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0107
    Cell Significance Index: 16.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0096
    Cell Significance Index: 4.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0087
    Cell Significance Index: 15.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0043
    Cell Significance Index: 5.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0286
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0638
    Cell Significance Index: -35.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0746
    Cell Significance Index: -2.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0926
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1071
    Cell Significance Index: -22.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1380
    Cell Significance Index: -15.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1611
    Cell Significance Index: -46.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1745
    Cell Significance Index: -2.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1793
    Cell Significance Index: -6.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1834
    Cell Significance Index: -26.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2258
    Cell Significance Index: -25.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2341
    Cell Significance Index: -4.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2470
    Cell Significance Index: -7.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2800
    Cell Significance Index: -3.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2801
    Cell Significance Index: -32.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2824
    Cell Significance Index: -8.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2855
    Cell Significance Index: -12.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2912
    Cell Significance Index: -8.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2921
    Cell Significance Index: -13.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3090
    Cell Significance Index: -8.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3393
    Cell Significance Index: -4.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3646
    Cell Significance Index: -10.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3866
    Cell Significance Index: -14.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3876
    Cell Significance Index: -30.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4014
    Cell Significance Index: -25.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4020
    Cell Significance Index: -24.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4164
    Cell Significance Index: -10.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4611
    Cell Significance Index: -11.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4710
    Cell Significance Index: -49.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5143
    Cell Significance Index: -3.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5457
    Cell Significance Index: -30.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6107
    Cell Significance Index: -11.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6337
    Cell Significance Index: -10.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6664
    Cell Significance Index: -33.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6861
    Cell Significance Index: -11.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7575
    Cell Significance Index: -17.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7646
    Cell Significance Index: -46.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7716
    Cell Significance Index: -16.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7729
    Cell Significance Index: -8.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipid-binding protein:** ANXA7 belongs to the annexin family, which is known for its ability to bind phospholipids, including phosphatidylserine and phosphatidylglycerol. 2. **Calcium-dependent signaling:** ANXA7 is involved in calcium-dependent signaling pathways, which regulate various cellular processes, including cell proliferation, differentiation, and apoptosis. 3. **Autophagy regulation:** ANXA7 has been shown to regulate autophagy, a process by which cells recycle damaged or dysfunctional proteins and organelles. 4. **Gene expression regulation:** ANXA7 can regulate gene expression by binding to specific DNA sequences and modulating the activity of transcription factors. **Pathways and Functions:** 1. **Autophagy:** ANXA7 regulates autophagy by interacting with autophagy-related proteins and modulating the activity of the autophagy machinery. 2. **Calcium-dependent signaling:** ANXA7 is involved in calcium-dependent signaling pathways, which regulate various cellular processes, including cell proliferation, differentiation, and apoptosis. 3. **Integrin binding:** ANXA7 can bind to integrins, which are transmembrane receptors that regulate cell adhesion and migration. 4. **Exosome regulation:** ANXA7 has been shown to regulate the formation and secretion of exosomes, which are small extracellular vesicles that carry proteins and RNA molecules. **Clinical Significance:** 1. **Immune regulation:** ANXA7 plays a crucial role in regulating immune responses, including the activation of immune cells and the production of cytokines. 2. **Cancer:** ANXA7 has been implicated in cancer development and progression, particularly in the regulation of autophagy and apoptosis. 3. **Neurological disorders:** ANXA7 has been shown to be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Reproductive health:** ANXA7 has been implicated in reproductive health, particularly in the regulation of embryonic development and implantation. **Conclusion:** Annexin A7 is a multifaceted protein with a wide range of cellular functions, including regulation of autophagy, calcium-dependent signaling, and gene expression. Its expression is widespread across different cell types, and it plays a crucial role in various physiological and pathological processes. Further research is needed to fully understand the mechanisms by which ANXA7 regulates cellular processes and to explore its potential therapeutic applications. **Future Directions:** 1. **Investigating ANXA7's role in specific diseases:** Further research is needed to investigate ANXA7's role in specific diseases, including cancer, neurological disorders, and reproductive health. 2. **Exploring ANXA7's therapeutic potential:** ANXA7 may have therapeutic potential in the treatment of various diseases, including cancer and neurological disorders. 3. **Investigating ANXA7's interaction with other proteins:** Further research is needed to investigate ANXA7's interaction with other proteins and to understand its role in specific cellular processes. **Limitations:** 1. **Limited understanding of ANXA7's mechanisms:** Despite its widespread expression, the mechanisms by which ANXA7 regulates cellular processes are not fully understood. 2. **Lack of specific ANXA7 antibodies:** The lack of specific ANXA7 antibodies limits the availability of reagents for studying ANXA7's function. 3. **Limited understanding of ANXA7's role in disease:** Further research is needed to fully understand ANXA7's role in disease and to explore its therapeutic potential.

Genular Protein ID: 1550699790

Symbol: ANXA7_HUMAN

Name: Annexin A7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2542947

Title: Calcium channel activity of purified human synexin and structure of the human synexin gene.

PubMed ID: 2542947

DOI: 10.1073/pnas.86.10.3798

PubMed ID: 7515686

Title: Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10.

PubMed ID: 7515686

DOI: 10.1021/bi00188a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1825209

Title: Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain.

PubMed ID: 1825209

DOI: 10.1016/s0021-9258(18)49978-4

PubMed ID: 18256029

Title: Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.

PubMed ID: 18256029

DOI: 10.1074/jbc.m800717200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 488
  • Mass: 52739
  • Checksum: BFC688479D8CC2A0
  • Sequence:
  • MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 
    PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 
    PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR 
    PAANFDAIRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK 
    SELSGNMEEL ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 
    SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY QAGEGRLGTD 
    ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF 
    FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR 
    LLLAIVGQ

Genular Protein ID: 51762458

Symbol: B2R657_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 488
  • Mass: 52640
  • Checksum: A57688479D966801
  • Sequence:
  • MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 
    PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 
    PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR 
    PAANFDAIRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK 
    SELSGNMEEL ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 
    SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY QAGEGRLGTD 
    ESCFNMILAT RSFPQLGATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF 
    FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR 
    LLLAIVGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.