Details for: ANXA7

Gene ID: 310

Symbol: ANXA7

Ensembl ID: ENSG00000138279

Description: annexin A7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.11
    Marker Score: 2544
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.08
    Marker Score: 776
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.05
    Marker Score: 8072
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.99
    Marker Score: 944
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.98
    Marker Score: 17197
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.96
    Marker Score: 7555
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 2001
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9
    Marker Score: 8193
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.89
    Marker Score: 761.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.87
    Marker Score: 6649
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.87
    Marker Score: 3067
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.87
    Marker Score: 2409
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.84
    Marker Score: 454
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.82
    Marker Score: 3222
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.8
    Marker Score: 20909
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.79
    Marker Score: 15408
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.78
    Marker Score: 4772
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.77
    Marker Score: 4318
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2594
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.73
    Marker Score: 2508
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.72
    Marker Score: 892
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.71
    Marker Score: 1526
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.7
    Marker Score: 1989
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.7
    Marker Score: 587
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.7
    Marker Score: 807
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.7
    Marker Score: 2705
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.7
    Marker Score: 490
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.69
    Marker Score: 601
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.67
    Marker Score: 399
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.67
    Marker Score: 42684
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.66
    Marker Score: 1310
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.66
    Marker Score: 3146
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.65
    Marker Score: 529
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.65
    Marker Score: 10534
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.63
    Marker Score: 1180
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.63
    Marker Score: 402
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.61
    Marker Score: 55757
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.61
    Marker Score: 510
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.6
    Marker Score: 360
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.6
    Marker Score: 11884
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.59
    Marker Score: 5463
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.58
    Marker Score: 15676
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.58
    Marker Score: 13596
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.58
    Marker Score: 1605
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.58
    Marker Score: 3976
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.57
    Marker Score: 2949
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.57
    Marker Score: 990
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.56
    Marker Score: 14869
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.56
    Marker Score: 2514
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.56
    Marker Score: 16137
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.56
    Marker Score: 5785
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.56
    Marker Score: 858
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.56
    Marker Score: 52919
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.55
    Marker Score: 1660
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.54
    Marker Score: 3504
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.54
    Marker Score: 378
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.53
    Marker Score: 2036
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.53
    Marker Score: 1623
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.53
    Marker Score: 1044
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.53
    Marker Score: 93855
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.52
    Marker Score: 1045.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.52
    Marker Score: 915
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.51
    Marker Score: 2505
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.5
    Marker Score: 55219
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.49
    Marker Score: 2725
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.49
    Marker Score: 3901
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1546
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.49
    Marker Score: 1602
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.48
    Marker Score: 4092
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.48
    Marker Score: 1384
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.47
    Marker Score: 424
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.46
    Marker Score: 1590
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.46
    Marker Score: 2864
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.46
    Marker Score: 13734
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.45
    Marker Score: 852
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.45
    Marker Score: 761
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.44
    Marker Score: 589
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.44
    Marker Score: 6188
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.44
    Marker Score: 54668
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.44
    Marker Score: 1588
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.44
    Marker Score: 80347
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.43
    Marker Score: 5871
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.43
    Marker Score: 817
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.43
    Marker Score: 1315
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.43
    Marker Score: 21381
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.43
    Marker Score: 667
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.43
    Marker Score: 1278
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.42
    Marker Score: 492
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.42
    Marker Score: 361
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.42
    Marker Score: 635
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.42
    Marker Score: 401
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.42
    Marker Score: 1111
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.41
    Marker Score: 309.5
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.41
    Marker Score: 374
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.41
    Marker Score: 1768
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.41
    Marker Score: 6925
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.41
    Marker Score: 11002
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.41
    Marker Score: 365
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 819
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.4
    Marker Score: 1646

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Other Information

**Key characteristics:** - An annexin A7 protein is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the annexin family of proteins, which are involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - Annexin A7 is a highly conserved protein, with similar sequences found in organisms ranging from yeast to humans. **Pathways and functions:** - Annexin A7 is involved in a variety of cellular pathways, including autophagy, calcium signaling, and cell differentiation. - In autophagy, Annexin A7 is a key regulator of the selective autophagy pathway, which is responsible for the degradation of damaged or non-functional proteins. - In calcium signaling, Annexin A7 is a key regulator of calcium-dependent protein binding (CDPB) signaling. - In cell differentiation, Annexin A7 is expressed in cells that are committed to a particular cell fate. This expression is important for the proper differentiation of cells into their final phenotype. **Clinical significance:** - Mutations in Annexin A7 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - In cancer, Annexin A7 mutations can lead to the survival of cancer cells, as they promote cell growth, migration, and invasion. - Targeting Annexin A7 has been investigated as a therapeutic strategy for cancer, but it has not been successful so far.

Genular Protein ID: 1550699790

Symbol: ANXA7_HUMAN

Name: Annexin A7

UniProtKB Accession Codes:

P20073 Q5F2H3 Q5T0M6 Q5T0M7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2542947

Title: Calcium channel activity of purified human synexin and structure of the human synexin gene.

PubMed ID: 2542947

DOI: 10.1073/pnas.86.10.3798

PubMed ID: 7515686

Title: Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10.

PubMed ID: 7515686

DOI: 10.1021/bi00188a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1825209

Title: Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain.

PubMed ID: 1825209

DOI: 10.1016/s0021-9258(18)49978-4

PubMed ID: 18256029

Title: Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.

PubMed ID: 18256029

DOI: 10.1074/jbc.m800717200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 488
  • Mass: 52739
  • Checksum: BFC688479D8CC2A0
  • Sequence:
    • MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 
PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 
PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR 
PAANFDAIRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK 
SELSGNMEEL ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY QAGEGRLGTD 
ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF 
FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR 
LLLAIVGQ

Genular Protein ID: 51762458

Symbol: B2R657_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R657

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 488
  • Mass: 52640
  • Checksum: A57688479D966801
  • Sequence:
    • MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 
PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 
PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR 
PAANFDAIRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK 
SELSGNMEEL ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY QAGEGRLGTD 
ESCFNMILAT RSFPQLGATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF 
FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR 
LLLAIVGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.