Details for: Dredd

Gene ID: 31011

Symbol: Dredd

Ensembl ID: FBgn0020381

Description: Death related ced-3/Nedd2-like caspase

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cysteine-type endopeptidase activity
    (GO:0004197)
  • Cysteine-type endopeptidase activity involved in execution phase of apoptosis
    (GO:0097200)
  • Cysteine-type peptidase activity
    (GO:0008234)
  • Cytoplasm
    (GO:0005737)
  • Defense response
    (GO:0006952)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Endopeptidase activity
    (GO:0004175)
  • Enzyme activator activity
    (GO:0008047)
  • Execution phase of apoptosis
    (GO:0097194)
  • Immune response
    (GO:0006955)
  • Innate immune response
    (GO:0045087)
  • Negative regulation of programmed cell death
    (GO:0043069)
  • Peptidoglycan recognition protein signaling pathway
    (GO:0061057)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of antibacterial peptide biosynthetic process
    (GO:0006963)
  • Positive regulation of biosynthetic process of antibacterial peptides active against gram-negative bacteria
    (GO:0006964)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Protein binding
    (GO:0005515)
  • Protein processing
    (GO:0016485)
  • Proteolysis
    (GO:0006508)
  • Sperm individualization
    (GO:0007291)

Other Information

Genular Protein ID: 4059561032

Symbol: CASP8_DROME

Name: Caspase-8

UniProtKB Accession Codes:

Q8IRY7 O02433 O76797 O76798 Q95T94 Q9UB42 Q9W5E3

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EC 2 EMBL 9 EnsemblMetazoa 3 ExpressionAtlas 1 FlyBase 1 GO 21 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MEROPS 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 13 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9740659

Title: Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.

PubMed ID: 9740659

DOI: 10.1006/dbio.1998.9000

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 10731137

Title: From sequence to chromosome: the tip of the X chromosome of D. melanogaster.

PubMed ID: 10731137

DOI: 10.1126/science.287.5461.2220

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 9380701

Title: CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.

PubMed ID: 9380701

DOI: 10.1073/pnas.94.20.10717

PubMed ID: 11269502

Title: The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection.

PubMed ID: 11269502

DOI: 10.1093/embo-reports/kvd073

PubMed ID: 10934188

Title: dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD.

PubMed ID: 10934188

DOI: 10.1074/jbc.c000341200

PubMed ID: 22549468

Title: Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

PubMed ID: 22549468

DOI: 10.1038/emboj.2012.121

Sequence Information:

  • Length: 494
  • Mass: 56153
  • Checksum: B9730DB3FDC58D4C
  • Sequence:
    • MAGSNLLIHL DTIDQNDLIY VERDMNFAQK VGLCFLLYGD DHSDATYILQ KLLAMTRSDF 
PQSDLLIKFA KSRPETWRRH LVEALCIIGA RKVLRRLGFC WQELRMHYLP HIAGITLHVH 
PLLKSLYRMC EELSLVQSGR LLLDVREKVE SQQAGDPLRF YDPAYLEIFL LDWLTRRSIK 
LGDINAAGSD VQLLVGHLKS NGLQAQANLL KDTIISNAPE PDAAGTAAMA VKQEIESDNQ 
QSYCSTQIDA LKLTRENAGI ALIINQQKFH RNVSRDNMKF LSPDPLRRRD GTDVDKERLI 
EVFSSMGYNV EAYDNVDHMG IIERIRSACD RSLVRDSLVV FILSHGFEEA VYASNSIAMK 
ITDIEDLLCS YDTLYYKPKL LIIQACQEKL VHKKKPNELF RIDVTTVSPD QHIDMLRAMS 
TVNGYAALRH TQTGSWFIGS LCDAIDRRSA SEHIADILTI VTNEVSKKRG SNDESMVPNV 
KSTFRQHVYF PPRL

Genular Protein ID: 1632272342

Symbol: X2JHT0_DROME

Name: N/A

UniProtKB Accession Codes:

X2JHT0

Database IDs:

AGR 1 ARBA 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 440
  • Mass: 50041
  • Checksum: D0BC45BAA414FDF8
  • Sequence:
    • MTRSDFPQSD LLIKFAKSRP ETWRRHLVEA LCIIGARKVL RRLGFCWQEL RMHYLPHIAG 
ITLHVHPLLK SLYRMCEELS LVQSGRLLLD VREKVESQQA GDPLRFYDPA YLEIFLLDWL 
TRRSIKLGDI NAAGSDVQLL VGHLKSNGLQ AQANLLKDTI ISNAPEPDAA GTAAMAVKQE 
IESDNQQSYC STQIDALKLT RENAGIALII NQQKFHRNVS RDNMKFLSPD PLRRRDGTDV 
DKERLIEVFS SMGYNVEAYD NVDHMGIIER IRSACDRSLV RDSLVVFILS HGFEEAVYAS 
NSIAMKITDI EDLLCSYDTL YYKPKLLIIQ ACQEKLVHKK KPNELFRIDV TTVSPDQHID 
MLRAMSTVNG YAALRHTQTG SWFIGSLCDA IDRRSASEHI ADILTIVTNE VSKKRGSNDE 
SMVPNVKSTF RQHVYFPPRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.