Details for: ANXA11

Gene ID: 311

Symbol: ANXA11

Ensembl ID: ENSG00000122359

Description: annexin A11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3
    Marker Score: 2043
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.97
    Marker Score: 2342
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.95
    Marker Score: 5147
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.72
    Marker Score: 2881.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.69
    Marker Score: 23411
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.66
    Marker Score: 6716
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.61
    Marker Score: 1743
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.6
    Marker Score: 4738
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.58
    Marker Score: 6925
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.57
    Marker Score: 8077
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.53
    Marker Score: 2660
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.5
    Marker Score: 15943
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.48
    Marker Score: 4111
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.46
    Marker Score: 10530
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.43
    Marker Score: 18108
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.42
    Marker Score: 23969
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.41
    Marker Score: 6645
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.39
    Marker Score: 11464
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.39
    Marker Score: 5826.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.39
    Marker Score: 3513
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.38
    Marker Score: 2052
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.34
    Marker Score: 14982.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.32
    Marker Score: 129632
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.3
    Marker Score: 58788
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.28
    Marker Score: 120636
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.25
    Marker Score: 3182
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.24
    Marker Score: 7062
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.22
    Marker Score: 76987
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.22
    Marker Score: 2588
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.2
    Marker Score: 1044
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.18
    Marker Score: 2632
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.17
    Marker Score: 3881
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.17
    Marker Score: 1029
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.15
    Marker Score: 4083
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.14
    Marker Score: 2765
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.13
    Marker Score: 2576
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.13
    Marker Score: 18378.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.12
    Marker Score: 527
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.12
    Marker Score: 2346
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.12
    Marker Score: 612
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.11
    Marker Score: 8293
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.09
    Marker Score: 3697
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.09
    Marker Score: 5088
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.07
    Marker Score: 7978.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.06
    Marker Score: 10839
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.06
    Marker Score: 2089
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.05
    Marker Score: 4654
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.04
    Marker Score: 3552
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.03
    Marker Score: 1480
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.02
    Marker Score: 5034
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.02
    Marker Score: 2310
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.01
    Marker Score: 3924.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.01
    Marker Score: 1180
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.01
    Marker Score: 712.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.99
    Marker Score: 1859
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.98
    Marker Score: 1865
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.97
    Marker Score: 882
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.96
    Marker Score: 6744
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.95
    Marker Score: 3100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.95
    Marker Score: 2867
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.94
    Marker Score: 2019
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.93
    Marker Score: 7915
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.93
    Marker Score: 5422
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.91
    Marker Score: 5564
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9
    Marker Score: 454
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.89
    Marker Score: 2913
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.88
    Marker Score: 928
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.88
    Marker Score: 14664
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.86
    Marker Score: 2020
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.84
    Marker Score: 1620
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.84
    Marker Score: 1351
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.83
    Marker Score: 1755
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.83
    Marker Score: 1554
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.82
    Marker Score: 4322
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.82
    Marker Score: 1059
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.81
    Marker Score: 995.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.79
    Marker Score: 6369
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.78
    Marker Score: 514
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.78
    Marker Score: 833
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.78
    Marker Score: 2460
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.78
    Marker Score: 511
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.77
    Marker Score: 2507.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.77
    Marker Score: 1035
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.74
    Marker Score: 1366.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.74
    Marker Score: 4552
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.74
    Marker Score: 1046
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.73
    Marker Score: 1459.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.73
    Marker Score: 1650
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.72
    Marker Score: 1849.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.72
    Marker Score: 1405
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.71
    Marker Score: 7394.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.71
    Marker Score: 402
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.71
    Marker Score: 644
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.71
    Marker Score: 737
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.71
    Marker Score: 981
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.7
    Marker Score: 1169
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.7
    Marker Score: 935
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.7
    Marker Score: 422
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.68
    Marker Score: 416
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 866

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Other Information

**Key characteristics:** - Annexin A11 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the annexin family of proteins, which are involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - Annexin A11 is a calcium-dependent protein that is expressed in high levels in cells that are exposed to calcium ions. - It is involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** - Annexin A11 is involved in the calcium-dependent phospholipid binding pathway, which is a signaling pathway that is involved in cell migration and adhesion. - It also plays a role in the cytoplasm, where it is involved in the regulation of cell cycle progression and apoptosis. - Annexin A11 is also involved in the regulation of the nuclear envelope, the nucleoplasm, and the endosomal system. - It is involved in the regulation of phagocytosis, where it is expressed in cells that are taking up foreign particles. - Annexin A11 is also involved in the regulation of the spindle, where it is expressed in cells that are dividing. **Clinical significance:** - Mutations in the ANXA11 gene have been linked to a number of human diseases, including breast cancer, prostate cancer, and colon cancer. - Annexin A11 is a potential target for cancer therapy, as it is expressed in high levels in cancer cells. - Targeting Annexin A11 with antibodies or small molecules could inhibit cancer cell growth and metastasis.

Genular Protein ID: 936798562

Symbol: ANX11_HUMAN

Name: Annexin A11

UniProtKB Accession Codes:

P50995 B4DVE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 7 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7508441

Title: The 56K autoantigen is identical to human annexin XI.

PubMed ID: 7508441

DOI: 10.1016/s0021-9258(17)41769-8

PubMed ID: 11013079

Title: Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms.

PubMed ID: 11013079

DOI: 10.1006/geno.2000.6309

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11883939

Title: ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner.

PubMed ID: 11883939

DOI: 10.1006/bbrc.2002.6600

PubMed ID: 12601007

Title: Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope.

PubMed ID: 12601007

DOI: 10.1074/jbc.m212669200

PubMed ID: 12805373

Title: Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display.

PubMed ID: 12805373

DOI: 10.1074/jbc.m210852200

PubMed ID: 15197175

Title: Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis.

PubMed ID: 15197175

DOI: 10.1083/jcb.200311054

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18256029

Title: Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.

PubMed ID: 18256029

DOI: 10.1074/jbc.m800717200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28469040

Title: Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

PubMed ID: 28469040

DOI: 10.1126/scitranslmed.aad9157

PubMed ID: 34048612

Title: A Novel Multisystem Proteinopathy Caused by a Missense ANXA11 Variant.

PubMed ID: 34048612

DOI: 10.1002/ana.26136

Sequence Information:

  • Length: 505
  • Mass: 54390
  • Checksum: 4ADCAC8F270BFEE4
  • Sequence:
    • MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN 
MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY 
PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT 
PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL 
SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA 
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD 
AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE 
GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS 
LYHDISGDTS GDYRKILLKI CGGND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.