Details for: ANXA11

Gene ID: 311

Symbol: ANXA11

Ensembl ID: ENSG00000122359

Description: annexin A11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 382.1075
    Cell Significance Index: -59.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.6861
    Cell Significance Index: -51.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 153.7089
    Cell Significance Index: -63.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.5360
    Cell Significance Index: -57.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.1992
    Cell Significance Index: -61.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.3099
    Cell Significance Index: -62.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.2622
    Cell Significance Index: -61.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.8227
    Cell Significance Index: -58.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.7568
    Cell Significance Index: -60.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.5168
    Cell Significance Index: -61.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.8643
    Cell Significance Index: -45.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2855
    Cell Significance Index: -35.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.2688
    Cell Significance Index: -29.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.3410
    Cell Significance Index: 39.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.7072
    Cell Significance Index: 192.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1448
    Cell Significance Index: 92.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.0716
    Cell Significance Index: 334.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4244
    Cell Significance Index: 65.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3989
    Cell Significance Index: 432.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3779
    Cell Significance Index: 292.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1750
    Cell Significance Index: 50.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7909
    Cell Significance Index: 33.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7724
    Cell Significance Index: 83.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7588
    Cell Significance Index: 960.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7382
    Cell Significance Index: 129.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5147
    Cell Significance Index: 303.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3721
    Cell Significance Index: 105.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3032
    Cell Significance Index: 168.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2800
    Cell Significance Index: 36.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2372
    Cell Significance Index: 33.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1897
    Cell Significance Index: 163.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1503
    Cell Significance Index: 59.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1124
    Cell Significance Index: 50.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9915
    Cell Significance Index: 116.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6781
    Cell Significance Index: 86.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6771
    Cell Significance Index: 18.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6675
    Cell Significance Index: 11.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6229
    Cell Significance Index: 40.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5876
    Cell Significance Index: 29.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5770
    Cell Significance Index: 38.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5326
    Cell Significance Index: 7.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5172
    Cell Significance Index: 228.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4393
    Cell Significance Index: 20.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4073
    Cell Significance Index: 80.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4051
    Cell Significance Index: 69.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3798
    Cell Significance Index: 13.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2860
    Cell Significance Index: 46.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2525
    Cell Significance Index: 17.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1918
    Cell Significance Index: 18.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1766
    Cell Significance Index: 33.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1728
    Cell Significance Index: 3.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1491
    Cell Significance Index: 53.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1323
    Cell Significance Index: 96.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1274
    Cell Significance Index: 3.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1194
    Cell Significance Index: 1.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0549
    Cell Significance Index: 103.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0447
    Cell Significance Index: 33.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0434
    Cell Significance Index: 0.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0391
    Cell Significance Index: 35.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0347
    Cell Significance Index: 63.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0154
    Cell Significance Index: -1.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0202
    Cell Significance Index: -12.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -15.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0352
    Cell Significance Index: -15.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0394
    Cell Significance Index: -53.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0652
    Cell Significance Index: -36.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0727
    Cell Significance Index: -8.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0845
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1292
    Cell Significance Index: -27.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1837
    Cell Significance Index: -52.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1920
    Cell Significance Index: -6.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1950
    Cell Significance Index: -2.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2016
    Cell Significance Index: -29.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2023
    Cell Significance Index: -23.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2490
    Cell Significance Index: -29.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2646
    Cell Significance Index: -10.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2860
    Cell Significance Index: -22.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3472
    Cell Significance Index: -5.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3609
    Cell Significance Index: -4.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3936
    Cell Significance Index: -9.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4165
    Cell Significance Index: -10.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5426
    Cell Significance Index: -56.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5758
    Cell Significance Index: -12.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6607
    Cell Significance Index: -5.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7791
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.8677
    Cell Significance Index: -5.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9970
    Cell Significance Index: -28.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0060
    Cell Significance Index: -61.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0147
    Cell Significance Index: -62.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0200
    Cell Significance Index: -26.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0356
    Cell Significance Index: -65.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0668
    Cell Significance Index: -26.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0671
    Cell Significance Index: -31.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0728
    Cell Significance Index: -60.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0821
    Cell Significance Index: -31.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0836
    Cell Significance Index: -18.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0859
    Cell Significance Index: -22.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANXA11 is a small, acidic protein with a molecular weight of approximately 11 kDa. It belongs to the annexin family, which is characterized by its ability to bind to phospholipids, proteins, and calcium ions. ANXA11 exhibits a high degree of specificity in its binding interactions, which are mediated by its unique amino acid sequence and structural properties. The protein is highly expressed in various cell types, including squamous epithelial cells, epithelial cells of the urethra, germ cells, and immune cells. **Pathways and Functions:** ANXA11 is involved in several biological pathways, including: 1. **Calcium-dependent phospholipid binding**: ANXA11 binds to phospholipids, such as phosphatidylethanolamine and phosphatidylserine, in a calcium-dependent manner, which regulates membrane trafficking and cell signaling. 2. **Protein binding**: ANXA11 interacts with various proteins, including S100 proteins, which modulate its activity and regulate cellular processes. 3. **Membrane trafficking**: ANXA11 regulates membrane trafficking by interacting with phospholipids and proteins, which affects cellular processes such as phagocytosis and exocytosis. 4. **Cytokine regulation**: ANXA11 modulates cytokine signaling by interacting with cytokine receptors and regulating their activity. 5. **Cell signaling**: ANXA11 regulates cell signaling by interacting with various signaling molecules, including calcium ions and phospholipids. **Clinical Significance:** ANXA11 has been implicated in several diseases and disorders, including: 1. **Immunodeficiency**: ANXA11 has been shown to play a role in the regulation of immune cell function and signaling, which is critical in the context of immunodeficiency diseases. 2. **Cancer**: ANXA11 has been implicated in cancer progression, where it regulates cell signaling and membrane trafficking. 3. **Neurological disorders**: ANXA11 has been shown to play a role in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates calcium-dependent phospholipid binding and membrane trafficking. 4. **Infectious diseases**: ANXA11 has been implicated in infectious diseases, including HIV-1 and tuberculosis, where it regulates immune cell function and signaling. In conclusion, ANXA11 is a multifunctional protein that plays critical roles in various biological pathways, including calcium-dependent phospholipid binding, protein binding, and membrane trafficking. Its clinical significance is evident in its involvement in immunodeficiency, cancer, neurological disorders, and infectious diseases. Further research is needed to fully elucidate the roles of ANXA11 in human health and disease.

Genular Protein ID: 936798562

Symbol: ANX11_HUMAN

Name: Annexin A11

UniProtKB Accession Codes:

P50995 B4DVE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 7 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7508441

Title: The 56K autoantigen is identical to human annexin XI.

PubMed ID: 7508441

DOI: 10.1016/s0021-9258(17)41769-8

PubMed ID: 11013079

Title: Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms.

PubMed ID: 11013079

DOI: 10.1006/geno.2000.6309

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11883939

Title: ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner.

PubMed ID: 11883939

DOI: 10.1006/bbrc.2002.6600

PubMed ID: 12601007

Title: Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope.

PubMed ID: 12601007

DOI: 10.1074/jbc.m212669200

PubMed ID: 12805373

Title: Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display.

PubMed ID: 12805373

DOI: 10.1074/jbc.m210852200

PubMed ID: 15197175

Title: Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis.

PubMed ID: 15197175

DOI: 10.1083/jcb.200311054

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18256029

Title: Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.

PubMed ID: 18256029

DOI: 10.1074/jbc.m800717200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28469040

Title: Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

PubMed ID: 28469040

DOI: 10.1126/scitranslmed.aad9157

PubMed ID: 34048612

Title: A Novel Multisystem Proteinopathy Caused by a Missense ANXA11 Variant.

PubMed ID: 34048612

DOI: 10.1002/ana.26136

Sequence Information:

  • Length: 505
  • Mass: 54390
  • Checksum: 4ADCAC8F270BFEE4
  • Sequence:
    • MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN 
MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY 
PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT 
PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL 
SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA 
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD 
AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE 
GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS 
LYHDISGDTS GDYRKILLKI CGGND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.