Details for: ANXA13

Gene ID: 312

Symbol: ANXA13

Ensembl ID: ENSG00000104537

Description: annexin A13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.5600
    Cell Significance Index: -6.4200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 8.9193
    Cell Significance Index: 67.6400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.2905
    Cell Significance Index: 53.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.9278
    Cell Significance Index: 141.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8964
    Cell Significance Index: 62.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8520
    Cell Significance Index: -7.6400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.7109
    Cell Significance Index: 29.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4416
    Cell Significance Index: 265.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8612
    Cell Significance Index: 30.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8429
    Cell Significance Index: 110.6400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.5785
    Cell Significance Index: 5.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2579
    Cell Significance Index: 26.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.2325
    Cell Significance Index: 43.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9637
    Cell Significance Index: 14.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5269
    Cell Significance Index: 52.1200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.4935
    Cell Significance Index: 3.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4503
    Cell Significance Index: 20.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3885
    Cell Significance Index: 9.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3202
    Cell Significance Index: 52.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3027
    Cell Significance Index: 44.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2239
    Cell Significance Index: 42.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1143
    Cell Significance Index: 3.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1108
    Cell Significance Index: 2.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1103
    Cell Significance Index: 21.8900
  • Cell Name: sperm (CL0000019)
    Fold Change: 0.0720
    Cell Significance Index: 0.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0473
    Cell Significance Index: 0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0337
    Cell Significance Index: 63.5100
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0330
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0073
    Cell Significance Index: 5.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0007
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0021
    Cell Significance Index: -1.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0031
    Cell Significance Index: -1.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0064
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0077
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0089
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0105
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0107
    Cell Significance Index: -4.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0107
    Cell Significance Index: -1.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0133
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0143
    Cell Significance Index: -2.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0211
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0249
    Cell Significance Index: -2.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0255
    Cell Significance Index: -1.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0281
    Cell Significance Index: -5.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0384
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0402
    Cell Significance Index: -4.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0409
    Cell Significance Index: -5.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0418
    Cell Significance Index: -1.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0497
    Cell Significance Index: -1.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0546
    Cell Significance Index: -5.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0568
    Cell Significance Index: -4.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0572
    Cell Significance Index: -1.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0581
    Cell Significance Index: -7.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0589
    Cell Significance Index: -1.0100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0635
    Cell Significance Index: -0.9500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0652
    Cell Significance Index: -0.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0741
    Cell Significance Index: -3.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0793
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0847
    Cell Significance Index: -6.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0871
    Cell Significance Index: -3.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0884
    Cell Significance Index: -5.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0898
    Cell Significance Index: -1.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0936
    Cell Significance Index: -1.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0948
    Cell Significance Index: -1.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1033
    Cell Significance Index: -7.7000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1042
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1046
    Cell Significance Index: -2.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1162
    Cell Significance Index: -5.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1169
    Cell Significance Index: -5.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1181
    Cell Significance Index: -7.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1237
    Cell Significance Index: -6.9400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1306
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1316
    Cell Significance Index: -0.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1318
    Cell Significance Index: -2.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1339
    Cell Significance Index: -5.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1378
    Cell Significance Index: -4.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1407
    Cell Significance Index: -4.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1435
    Cell Significance Index: -4.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1498
    Cell Significance Index: -5.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1506
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1508
    Cell Significance Index: -2.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1511
    Cell Significance Index: -7.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1599
    Cell Significance Index: -4.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1619
    Cell Significance Index: -8.4100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1672
    Cell Significance Index: -2.1600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1699
    Cell Significance Index: -1.9000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1765
    Cell Significance Index: -2.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** ANXA13 is primarily found in the cytoplasm, cytoplasmic vesicles, and plasma membrane, suggesting its involvement in membrane-bound processes. 2. **Binding properties:** ANXA13 exhibits calcium-dependent phospholipid binding, phosphatidylglycerol binding, and phosphatidylserine binding, indicating its ability to interact with specific lipids. 3. **Signaling pathways:** ANXA13 is involved in various signaling pathways, including calcium-dependent phospholipid binding, which is crucial for cell differentiation and membrane trafficking. 4. **Expression patterns:** ANXA13 is significantly expressed in distinct cell types, including amacrine cells, goblet cells, and GABAergic interneurons, suggesting its role in specific cellular processes. **Pathways and Functions:** 1. **Calcium-dependent phospholipid binding:** ANXA13's ability to bind calcium-dependent phospholipids is crucial for its role in cell differentiation and membrane trafficking. 2. **Cell differentiation:** ANXA13's involvement in calcium-dependent phospholipid binding and signaling pathways makes it essential for cell differentiation, particularly in the context of neurodevelopment. 3. **Membrane trafficking:** ANXA13's interaction with phospholipids and its localization in cytoplasmic vesicles and plasma membrane suggest its role in membrane trafficking and transport. 4. **Extracellular vesicle formation:** ANXA13's involvement in extracellular vesicle formation and release indicates its potential role in intercellular communication. **Clinical Significance:** 1. **Neurodegenerative diseases:** ANXA13's expression in GABAergic interneurons and its involvement in calcium-dependent phospholipid binding make it a potential target for the study of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** ANXA13's expression in various cancer cell types, including granulocyte monocyte progenitor cells and cardiac muscle myoblasts, suggests its potential role in cancer development and progression. 3. **Regenerative medicine:** ANXA13's involvement in cell differentiation and membrane trafficking makes it a promising target for regenerative medicine, particularly in the context of tissue repair and repair. In conclusion, ANXA13 is a multifunctional protein that plays a crucial role in various cellular processes, including cell differentiation, signaling, and membrane trafficking. Its unique characteristics, pathways, and functions make it an attractive target for further investigation, particularly in the context of neurodegenerative diseases and cancer. Further research is needed to fully elucidate the role of ANXA13 in human health and disease.

Genular Protein ID: 1919233091

Symbol: ANX13_HUMAN

Name: Annexin A13

UniProtKB Accession Codes:

P27216 Q9BQR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1530946

Title: A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.

PubMed ID: 1530946

DOI: 10.1083/jcb.116.2.405

PubMed ID: 11961095

Title: Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins.

PubMed ID: 11961095

DOI: 10.1093/oxfordjournals.molbev.a004120

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27676605

Title: Structural and lipid-binding characterization of human annexin A13a reveals strong differences with its long A13b isoform.

PubMed ID: 27676605

DOI: 10.1515/hsz-2016-0242

PubMed ID: 30610115

Title: An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.

PubMed ID: 30610115

DOI: 10.1074/jbc.ra118.004571

Sequence Information:

  • Length: 316
  • Mass: 35415
  • Checksum: 3F61A1AECE5A067D
  • Sequence:
    • MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 
GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE 
IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 
AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 
RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 
SDTSGDFRKL LVALLH

Genular Protein ID: 1355072102

Symbol: Q53FB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FB5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 316
  • Mass: 35343
  • Checksum: 3C01A1AECD3A071D
  • Sequence:
    • MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 
GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE 
IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 
AGEGRWGTDG LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 
RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 
SDTSGDFRKL LVALLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.