Details for: ANXA13

Gene ID: 312

Symbol: ANXA13

Ensembl ID: ENSG00000104537

Description: annexin A13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 6.05
    Marker Score: 19385.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.54
    Marker Score: 1475
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.44
    Marker Score: 6929
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.19
    Marker Score: 259
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.14
    Marker Score: 2367
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.06
    Marker Score: 258
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15835
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1549
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.93
    Marker Score: 2219
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1639
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.84
    Marker Score: 1298
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.78
    Marker Score: 2234
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.74
    Marker Score: 392
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.69
    Marker Score: 260.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 323
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.66
    Marker Score: 662
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1339
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.65
    Marker Score: 170
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2670
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.62
    Marker Score: 242
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6
    Marker Score: 149
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.58
    Marker Score: 4922
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.55
    Marker Score: 284
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.51
    Marker Score: 126
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1178
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.48
    Marker Score: 333
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2972
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 267
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.44
    Marker Score: 704
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.41
    Marker Score: 296
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 143
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.33
    Marker Score: 402
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.32
    Marker Score: 1141
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 136
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3
    Marker Score: 1301
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.3
    Marker Score: 945
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 134
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.25
    Marker Score: 744.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 152.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.22
    Marker Score: 2931
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.21
    Marker Score: 614
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.21
    Marker Score: 196
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2
    Marker Score: 1172
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.18
    Marker Score: 595
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 66
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 687
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.16
    Marker Score: 181
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.14
    Marker Score: 177
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.12
    Marker Score: 30

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Other Information

**Key characteristics:** - ANXA13 is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a member of the annexin family of proteins, which are involved in cell adhesion, migration, and signaling. - ANXA13 is ubiquitously expressed, meaning that it is present in all cells. - It is highly expressed in immune cells, including macrophages, dendritic cells, and lymphocytes. **Pathways and functions:** - ANXA13 is involved in the apical plasma membrane, where it forms a complex with other proteins to regulate epithelial cell migration and cell adhesion. - It is also involved in the regulation of calcium signaling, and it has been shown to be important for the differentiation of intestinal goblet cells. - ANXA13 is also involved in the regulation of cell differentiation and survival. It is expressed in the developing embryo and is essential for the survival of cardiac muscle myoblasts and neuronal cells. **Clinical significance:** - Mutations in ANXA13 have been linked to several human diseases, including autism spectrum disorder, schizophrenia, and cancer. - ANXA13 is a potential therapeutic target for these diseases, as it is involved in the regulation of cell migration and differentiation. - A number of drugs that target ANXA13 have been developed and are currently being evaluated in clinical trials.

Genular Protein ID: 1919233091

Symbol: ANX13_HUMAN

Name: Annexin A13

UniProtKB Accession Codes:

P27216 Q9BQR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1530946

Title: A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.

PubMed ID: 1530946

DOI: 10.1083/jcb.116.2.405

PubMed ID: 11961095

Title: Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins.

PubMed ID: 11961095

DOI: 10.1093/oxfordjournals.molbev.a004120

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27676605

Title: Structural and lipid-binding characterization of human annexin A13a reveals strong differences with its long A13b isoform.

PubMed ID: 27676605

DOI: 10.1515/hsz-2016-0242

PubMed ID: 30610115

Title: An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.

PubMed ID: 30610115

DOI: 10.1074/jbc.ra118.004571

Sequence Information:

  • Length: 316
  • Mass: 35415
  • Checksum: 3F61A1AECE5A067D
  • Sequence:
    • MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 
GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE 
IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 
AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 
RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 
SDTSGDFRKL LVALLH

Genular Protein ID: 1355072102

Symbol: Q53FB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FB5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 316
  • Mass: 35343
  • Checksum: 3C01A1AECD3A071D
  • Sequence:
    • MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 
GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE 
IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 
AGEGRWGTDG LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 
RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 
SDTSGDFRKL LVALLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.