Gene HLA DRB4 - NCBI Gene ID: 3126

Details for: HLA DRB4

Gene ID: 3126

Symbol: HLA DRB4

Description: major histocompatibility complex, class II, DR beta 4

Associated with

Adaptive immune response
(GO:0002250)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Endocytic vesicle membrane
(GO:0030666)
Er to golgi transport vesicle membrane
(GO:0012507)
Golgi membrane
(GO:0000139)
Late endosome membrane
(GO:0031902)
Lumenal side of endoplasmic reticulum membrane
(GO:0098553)
Lysosomal membrane
(GO:0005765)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Positive regulation of t cell activation
(GO:0050870)
Trans-golgi network membrane
(GO:0032588)
Transport vesicle membrane
(GO:0030658)

Other Information

Proteins

HLA class II histocompatibility antigen, DR beta 4 chain

Genular Protein ID: 2860704347

Symbol: DRB4_HUMAN

Name: HLA class II histocompatibility antigen, DR beta 4 chain

UniProtKB Accession Codes:

P13762 B0S863 O78042 P79664 Q29889 Q30163 Q6TLK6 Q860N4 Q861F3 Q8WLT9 Q9BS54

Database IDs:

Citations:

PubMed ID: 3110774

Title: Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

PubMed ID: 3110774

DOI: 10.1073/pnas.84.14.4929

PubMed ID: 11972878

Title: Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033.

PubMed ID: 11972878

DOI: 10.1034/j.1399-0039.2002.590108.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3467350

Title: Evolutionary and genetic implications of sequence variation in two nonallelic HLA-DR beta-chain cDNA sequences.

PubMed ID: 3467350

DOI: 10.1073/pnas.84.1.209

PubMed ID: 3036826

Title: Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes.

PubMed ID: 3036826

DOI: 10.1016/s0021-9258(18)47480-7

PubMed ID: 9234493

Title: Identification of a new DRB4 allele (DRB4*0105) by sequence-based typing.

PubMed ID: 9234493

DOI: 10.1111/j.1399-0039.1997.tb02819.x

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 19117940

Title: The HLA-DRalpha chain is modified by polyubiquitination.

PubMed ID: 19117940

DOI: 10.1074/jbc.m805736200

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

Sequence Information:

Length: 266
Mass: 29941
Checksum: 96FF5FE572403FAE
Sequence:

MVCLKLPGGS CMAALTVTLT VLSSPLALAG DTQPRFLEQA KCECHFLNGT ERVWNLIRYI 
YNQEEYARYN SDLGEYQAVT ELGRPDAEYW NSQKDLLERR RAEVDTYCRY NYGVVESFTV 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVNG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSMM SPLTVQWSAR SESAQSKMLS GVGGFVLGLL 
FLGTGLFIYF RNQKGHSGLQ PTGLLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HLA DRB4

Associated with

Other Information

Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes. PubMed ID: 3110774

Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033. PubMed ID: 11972878

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evolutionary and genetic implications of sequence variation in two nonallelic HLA-DR beta-chain cDNA sequences. PubMed ID: 3467350

Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes. PubMed ID: 3036826

Identification of a new DRB4 allele (DRB4*0105) by sequence-based typing. PubMed ID: 9234493

Invariant chain structure and MHC class II function. PubMed ID: 8598037

Presentation of antigens by MHC class II molecules: getting the most out of them. PubMed ID: 11684289

Autophagy in MHC class II presentation: sampling from within. PubMed ID: 17241953

MHC class II molecules on the move for successful antigen presentation. PubMed ID: 18046453

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. PubMed ID: 18305173

The HLA-DRalpha chain is modified by polyubiquitination. PubMed ID: 19117940

MHC class II transport at a glance. PubMed ID: 19092054

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. PubMed ID: 19533806